Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin J Sonnemann"'
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001158 (2010)
Hair cell stereocilia structure depends on actin filaments composed of cytoplasmic β-actin and γ-actin isoforms. Mutations in either gene can lead to progressive hearing loss in humans. Since β-actin and γ-actin isoforms are 99% identical at the
Externí odkaz:
https://doaj.org/article/ea30eb6846ca4c44bfab8ce75806a2d4
Autor:
Kevin J Sonnemann, Hanke Heun-Johnson, Amy J Turner, Kristen A Baltgalvis, Dawn A Lowe, James M Ervasti
Publikováno v:
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
The loss of dystrophin compromises muscle cell membrane stability and causes Duchenne muscular dystrophy and/or various forms of cardiomyopathy. Increased expression of the dystrophin homolog utrophin by gene delivery or pharmacologic up-regulation h
Externí odkaz:
https://doaj.org/article/4fdad23a597c44f7b801c8d249d2427a
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa35768c7daf212b658676a27ab509c
https://doi.org/10.1096/fasebj.2018.32.1_supplement.542.29
https://doi.org/10.1096/fasebj.2018.32.1_supplement.542.29
Autor:
Kevin J. Sonnemann, William M. Bement
Publikováno v:
Annual Review of Cell and Developmental Biology. 27:237-263
The importance of wound healing to medicine and biology has long been evident, and consequently, wound healing has been the subject of intense investigation for many years. However, several relatively recent developments have added new impetus to wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a365c44b04b66e482f981c3886857b
https://doi.org/10.1146/annurev-cellbio-092910-154251
https://doi.org/10.1146/annurev-cellbio-092910-154251
Autor:
Karen H. Friderici, Edward J. Walsh, Mei Zhu, James M. Ervasti, Inna A. Belyantseva, Kevin J. Sonnemann, Benjamin J. Perrin, JoAnn McGee, Gregory I. Frolenkov, Ruben Stepanyan, Thomas B. Friedman
Publikováno v:
Proceedings of the National Academy of Sciences. 106:9703-9708
β cyto -Actin and γ cyto -actin are ubiquitous proteins thought to be essential building blocks of the cytoskeleton in all non-muscle cells. Despite this widely held supposition, we show that γ cyto -actin null mice ( Actg1 −/− ) are viable. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359c50fe59f44e89d181131a6636e00a
https://doi.org/10.1073/pnas.0900221106
https://doi.org/10.1073/pnas.0900221106
Publikováno v:
The FASEB Journal. 23:2205-2214
We generated transgenic mice that overexpressed γ-cyto actin 2000-fold above wild-type levels in skeletal muscle. γ-cyto actin comprised 40% of total actin in transgenic skeletal muscle, with a concomitant 40% decrease in α-actin. Surprisingly, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d1d93465bbaa531bf679318048d01c
https://doi.org/10.1096/fj.09-129783
https://doi.org/10.1096/fj.09-129783
Publikováno v:
Journal of Biological Chemistry. 281:9996-10001
This study was designed to define the molecular epitopes of dystrophin-actin interaction and to directly compare the actin binding properties of dystrophin and utrophin. According to our data, dystrophin and utrophin both bound alongside actin filame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7625fe8fe1cb2b6a3eec1283d6088b
https://doi.org/10.1074/jbc.m513121200
https://doi.org/10.1074/jbc.m513121200
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(7)
We generated transgenic mice that overexpressed γ-cyto actin 2000-fold above wild-type levels in skeletal muscle. γ-cyto actin comprised 40% of total actin in transgenic skeletal muscle, with a concomitant 40% decrease in α-actin. Surprisingly, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04841216e26fecdd118c2065c08768e8
https://pubmed.ncbi.nlm.nih.gov/19279140
https://pubmed.ncbi.nlm.nih.gov/19279140
Autor:
Kristen A. Baltgalvis, Hanke Heun-Johnson, Kevin J. Sonnemann, Dawn A. Lowe, James M. Ervasti, Amy J. Turner
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
James Ervasti and colleagues show that injection of a truncated form of utrophin transduced all tissues examined, integrated with members of the dystrophin complex, and reduced serum levels of creatine kinase in a mouse model of muscular dystrophy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7373a28eb38f2d9fceb94b5a25b93788
https://pubmed.ncbi.nlm.nih.gov/19478831
https://pubmed.ncbi.nlm.nih.gov/19478831
Autor:
James M, Ervasti, Kevin J, Sonnemann
Publikováno v:
International review of cytology. 265
Since its first description in 1990, the dystrophin-glycoprotein complex has emerged as a critical nexus for human muscular dystrophies arising from defects in a variety of distinct genes. Studies in mammals widely support a primary role for the dyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::260d6ac4ee9a34d302dc298650e723ce
https://pubmed.ncbi.nlm.nih.gov/18275889
https://pubmed.ncbi.nlm.nih.gov/18275889