Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Kevin J Morine"'
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30063 (2012)
Increased utrophin expression is known to reduce pathology in dystrophin-deficient skeletal muscles. Transgenic over-expression of PGC-1α has been shown to increase levels of utrophin mRNA and improve the histology of mdx muscles. Other reports have
Externí odkaz:
https://doaj.org/article/b9cd75de88dc46e1af4ece41d99b7b68
Autor:
Lawrence T Bish, Mark Yarchoan, Meg M Sleeper, Jeffrey A Gazzara, Kevin J Morine, Pedro Acosta, Elisabeth R Barton, H Lee Sweeney
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20856 (2011)
Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstra
Externí odkaz:
https://doaj.org/article/dd9d30e4e2ae4bbe8b03695216c160a3
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10230 (2010)
Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to characterize myostatin regulation following cardiomyocyte stress and to examine the role of myo
Externí odkaz:
https://doaj.org/article/8bc320743c3540ebbacd3809aeb2f033
Autor:
Kevin J Morine, Lawrence T Bish, Klara Pendrak, Meg M Sleeper, Elisabeth R Barton, H Lee Sweeney
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9176 (2010)
Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously described approaches to blocking myostatin signaling include injectio
Externí odkaz:
https://doaj.org/article/c82d615db8c641b4933c0ebbf297da65
Publikováno v:
Eur J Heart Fail
Aims To assess whether natriuretic peptides (NPs) can be used to reliably predict long-term therapeutic effect on clinical outcomes for patients with heart failure and reduced ejection fraction (HFrEF). Methods and results HFrEF intervention trials w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b6da8d4ab652ebd140207677c77d63
https://doi.org/10.1002/ejhf.1411
https://doi.org/10.1002/ejhf.1411
Autor:
Michele Esposito, Colin S. Hirst, Katherine L. Thayer, Sarah Newman, Navin K. Kapur, Lena Jorde, Carlos D. Davila, Vikram Paruchuri, Kevin J. Morine, Evan H. Whitehead
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: We describe the association between longitudinal hemodynamic changes and clinical outcomes in patients with cardiogenic shock (CS) receiving acute mechanical circulatory support devices (AMCS) at a single center. We hypothesized that impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1857395374d73caef6077ef3480473
http://europepmc.org/articles/PMC7905221
http://europepmc.org/articles/PMC7905221
Autor:
Nima Aghili, Shiva Annamalai, Robert Pedicini, Anas Hamadeh, Andrew Mullin, Navin K. Kapur, Catalina Breton, Michele Esposito, Ryan O'Kelly, David DeNofrio, Kevin J. Morine, Michael S. Kiernan
Publikováno v:
Artificial Organs. 43:125-131
Hemolysis is a potential limitation of percutaneously delivered left-sided mechanical circulatory support pumps, including trans valvular micro-axial flow pumps (TVP). Hemolytic biomarkers among durable left ventricular assist devices include lactate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6566e922f60c6c84b7d193d9073dcbcf
https://doi.org/10.1111/aor.13319
https://doi.org/10.1111/aor.13319
Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure
Autor:
Navin K. Kapur, Richard H. Karas, Vikram Paruchuri, Mark Aronovitz, Peter Natov, Kevin J. Morine, Xiaoying Qiao, Sam York, Yali Zhang
Publikováno v:
Circulation. 138:513-526
Background: Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counterregulatory pathways that serve to regulate TGF-β1 activity in heart fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13decba3dde67dd198b3405ed50f1754
https://doi.org/10.1161/circulationaha.117.031635
https://doi.org/10.1161/circulationaha.117.031635
Autor:
Robert Pedicini, Shiva Annamalai, Richard H. Karas, Xiaoying Qiao, Ethan J. Rowin, Kevin J. Morine, Courtney Bogins, Iris Z. Jaffe, Navin K. Kapur, Andrew Mullin, Peter Natov, Catalina Breton, Ayan R. Patel, Michele Esposito, Emily E. Mackey, Yali Zhang, Lara Reyelt, Vikram Paruchuri, Gavin R. Schnitzler
Publikováno v:
Journal of the American College of Cardiology. 72:501-514
Background Heart failure after an acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. We recently reported that activation of a transvalvular axial-flow pump in the left ventricle and delaying myocardial reperfusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab60c91956abe6e0d470a2f8b4e30ec
https://doi.org/10.1016/j.jacc.2018.05.034
https://doi.org/10.1016/j.jacc.2018.05.034
Autor:
Stuart D. Katz, Judith S. Hochman, Daniel Burkhoff, Richard H. Karas, Anuradha Lala, Navin K. Kapur, Michele Esposito, Yu Guo, Kevin J. Morine, Jinfeng Xu
Publikováno v:
Journal of Cardiac Failure. 24:148-156
The prevalence and significance of right ventricular dysfunction (RVD) in patients with cardiogenic shock due to acute myocardial infarction (AMI-CS) have not been well characterized. We hypothesized that RVD is common in AMI-CS and associated with w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518845a0c37cdc50e59b31ba1ebbe014
https://doi.org/10.1016/j.cardfail.2017.10.009
https://doi.org/10.1016/j.cardfail.2017.10.009