Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Kevin J McHugh"'
Autor:
Erin M. Euliano, Anushka Agrawal, Marina H. Yu, Tyler P. Graf, Emily M. Henrich, Alyssa A. Kunkel, Chia‐Chien Hsu, Tsvetelina Baryakova, Kevin J. McHugh
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 6, Pp n/a-n/a (2024)
Abstract Lymph node (LN)‐resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen‐presenting capabilities and proximity to a high concentration of immune cells. Direct intra‐LN injection has been sh
Externí odkaz:
https://doaj.org/article/d3736a03bc784763b5a924a500f74319
Autor:
Radha Gopal, Egemen Tutuncuoglu, Veli Bakalov, Karla Wasserloos, HuiHua Li, David Lemley, Louis J. DeVito, Nicholas J. Constantinesco, Douglas S. Reed, Kevin J. McHugh, Baskaran Chinnappan, Alexis R. Andreas, Abigail Maloy, Daniel Bain, John F. Alcorn, Bruce R. Pitt, Ata Murat Kaynar
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials wit
Externí odkaz:
https://doaj.org/article/24848568926048cabe301806378dc84f
Autor:
Peisen Zhang, Junli Meng, Yingying Li, Chen Yang, Yi Hou, Wen Tang, Kevin J. McHugh, Lihong Jing
Publikováno v:
The Innovation, Vol 2, Iss 4, Pp 100174- (2021)
A vast majority of cancer deaths occur as a result of metastasis. Unfortunately, effective treatments for metastases are currently lacking due to the difficulty of selectively targeting these small, delocalized tumors distributed across a variety of
Externí odkaz:
https://doaj.org/article/087464a30b9148ea87c60af7c3e1b180
Autor:
Helen E Rich, Danielle Antos, Collin C McCourt, Wen Quan Zheng, Louis J Devito, Kevin J McHugh, Radha Gopal, Jieru Wang, John F Alcorn
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0255309 (2021)
BackgroundType III interferon, or interferon lambda (IFNλ) is a crucial antiviral cytokine induced by influenza infection. While IFNλ is important for anti-viral host defense, published data demonstrate that IFNλ is pathogenic during influenza/bac
Externí odkaz:
https://doaj.org/article/164f797b44ad4746969acad593a6ba44
Publikováno v:
Nature Reviews Drug Discovery. 22:387-409
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de5f2993adba46e8d8360f7deb70426d
https://doi.org/10.1038/s41573-023-00670-0
https://doi.org/10.1038/s41573-023-00670-0
Autor:
Kevin J. McHugh
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 2, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/ecf55b7351eb41ad98f4ec5c128f76a7
Autor:
Brett H. Pogostin, Gabriel Saenz, Carson C. Cole, Erin M. Euliano, Jeffrey D. Hartgerink, Kevin J. McHugh
Publikováno v:
Bioconjugate Chemistry. 34:193-203
Recently, there has been increased interest in using mannan as an immunomodulatory bioconjugate. Despite notable immunological and functional differences between the reduced (R-Man) and oxidized (O-Man) forms of mannan, little is known about the impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35c0be04ee440afd2cc2f3470cbd4da
https://doi.org/10.1021/acs.bioconjchem.2c00461
https://doi.org/10.1021/acs.bioconjchem.2c00461
Autor:
Brett H. Pogostin, Kevin J. McHugh
Publikováno v:
Bioengineering, Vol 8, Iss 11, p 155 (2021)
Future infectious disease outbreaks are inevitable; therefore, it is critical that we maximize our readiness for these events by preparing effective public health policies and healthcare innovations. Although we do not know the nature of future patho
Externí odkaz:
https://doaj.org/article/88eece1186a845368375618a50e7e78f
Autor:
Kevin J McHugh, Dian Li, Jay C Wang, Leon Kwark, Jessica Loo, Venkata Macha, Sina Farsiu, Leo A Kim, Magali Saint-Geniez
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0216215 (2019)
Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimatel
Externí odkaz:
https://doaj.org/article/57ea3bce0b5b4aea8d3330500a8a13de
Autor:
Tyler P. Graf, Kadryn Kadasia, Sarah Melhorn, Eliza Kessler, Haisong Yang, Tsvetelina Baryakova, Samantha Brady, Kevin J. McHugh
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d42d691bffa740f6bf6bc81e008d0d
https://doi.org/10.3791/65147
https://doi.org/10.3791/65147