Zobrazeno 1 - 10
of 832
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Bart Neyns, Mark Middleton, Aurélien Marabelle, Ignacio Melero, Ke Liu, Nina Bhardwaj, Tanja D de Gruijl, Jason Chesney, Robert Coffin, Howard Kaufman, Diwakar Davar, Jason J Luke, Georgina V Long, Kevin J Harrington, Sherene Loi, Thierry de Baere, David J Pinato, Matthew Fury, Ciara M Kelly, Joshua D Brody, Robert H Andtbacka, Gregory Goldmacher, Anuradha D Khilnani, Rahul A Sheth, Stephen B Solomon, Philippe Szapary
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Intratumorally delivered immunotherapies have the potential to favorably alter the local tumor microenvironment and may stimulate systemic host immunity, offering an alternative or adjunct to other local and systemic treatments. Despite th
Externí odkaz:
https://doaj.org/article/c46bb380ab4f4bb8bdb94dd95f2f7c6b
Autor:
Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Oncolytic virus V937 showed activity and safety with intratumoral administration. This phase 1 study evaluated intravenous V937±pembrolizumab in patients with advanced solid tumors.Methods Patients had advanced non-small cell lung cancer
Externí odkaz:
https://doaj.org/article/07dff5f507bc4d64bce5f819f24c264d
Autor:
Paul R Barber, Rami Mustapha, Fabian Flores-Borja, Giovanna Alfano, Kenrick Ng, Gregory Weitsman, Luigi Dolcetti, Ali Abdulnabi Suwaidan, Felix Wong, Jose M Vicencio, Myria Galazi, James W Opzoomer, James N Arnold, Selvam Thavaraj, Shahram Kordasti, Jana Doyle, Jon Greenberg, Magnus T Dillon, Kevin J Harrington, Martin Forster, Anthony CC Coolen, Tony Ng
Publikováno v:
eLife, Vol 11 (2022)
Background: Advanced head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis, and biomarkers that predict response to treatment are highly desirable. The primary aim was to predict progression-free survival (PFS) with a mult
Externí odkaz:
https://doaj.org/article/f01407f956a24b9e8f9a0385ed5d4e28
Autor:
Joan Brunet, Josep Tabernero, Salvatore Grisanti, Matteo Lambertini, George Pentheroudakis, Bruno Vincenzi, Dirk Arnold, Juan Aguilar-Company, Paolo Pedrazzoli, Solange Peters, Luis Castelo-Branco, Emanuela Romano, Olivier Michielin, Ramon Salazar, Alessio Cortellini, Rossana Berardi, Aleix Prat, Spyridon Gennatas, Giuseppe Tonini, Urania Dafni, Kevin J Harrington, Paola Queirolo, David J Pinato, Francesca Mazzoni, David Viñal, Gino M Dettorre, Uma Mukherjee, Mark Bower, Alexia Bertuzzi, Ailsa Sita-Lumsden, Federica Biello, Andrea Patriarca, Alessandra Gennari, Maura Rossi, Zoi Tsourti, Vasileios Angelis, Jacobo Rogado, Teresa Alonso-Gordoa, Georgia Dimopoulou, Sylvain Pradervand, Marco Tucci, Fanny Pommeret, Marco Krengli
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background As management and prevention strategies against COVID-19 evolve, it is still uncertain whether prior exposure to immune checkpoint inhibitors (ICIs) affects COVID-19 severity in patients with cancer.Methods In a joint analysis of ICI recip
Externí odkaz:
https://doaj.org/article/b011e59004e14e2dab36152831044c2b
Autor:
Simon Smith, Hormas Ghadially, Kevin J Harrington, Alan A Melcher, Isla Leslie, Eva Crespo-Rodriguez, Galabina Bozhanova, Emmanuel C Patin, Harriet Whittock, Martin McLaughlin, Malin Pedersen, James Harper, Pablo Nenclares, Heba Soliman, Magnus T Dillon, Lorna Grove, Davina Northcote, Holly Baldock, Gabriella Baker, Joan Kyula, Jeane Guevara
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug
Externí odkaz:
https://doaj.org/article/352213c6f2484a688ddb7a66accbad6a
Autor:
Kevin J Harrington, Alan A Melcher, Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Harriet Whittock, Richard Buus, Syed Haider, Gareth Muirhead, Kate Newbold, Robert S Coffin, Richard G Vile, Dae Kim, Martin McLaughlin, Malin Pedersen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The aggressive clinical behavior of poorly differentiated and anaplastic thyroid cancers (PDTC and ATC) has proven challenging to treat, and survival beyond a few months from diagnosis is rare. Although 30%–60% of these tumors contain mu
Externí odkaz:
https://doaj.org/article/ad0aeec772af4e7bb8cf7fe2244c748e
Autor:
Dmitriy Zamarin, Howard L Kaufman, Dobrin Draganov, Sofia R Gameiro, Ilio Vitale, Sandy Adjemian, Aitziber Buqué Martinez, Timothy A Chan, Richard L Edelson, Lucia Gabriele, Encouse Golden, Kevin J Harrington, Dewan Md Sakib Hossain, Michael Karin, Juan Jose Lasarte, Sherene Loi, Gwenola Manic, Alan A Melcher, Karen L Mossman, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Bryan E Strauss, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/988b876661a144ee942a8a790aa6a723
Autor:
Dmitriy Zamarin, Howard L Kaufman, Dobrin Draganov, Sofia R Gameiro, Ilio Vitale, Sandy Adjemian, Aitziber Buqué Martinez, Timothy A Chan, Richard L Edelson, Lucia Gabriele, Encouse Golden, Kevin J Harrington, Dewan Md Sakib Hossain, Michael Karin, Juan Jose Lasarte, Sherene Loi, Gwenola Manic, Alan A Melcher, Karen L Mossman, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Bryan E Strauss, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenviro
Externí odkaz:
https://doaj.org/article/a9d90895f1e544d9989ad2cde51f79c0
Autor:
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Abstract Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreov
Externí odkaz:
https://doaj.org/article/ebe09b78de1144a5ac46382d903dbfad
Autor:
Marco Borri, Maria A Schmidt, Ceri Powell, Dow-Mu Koh, Angela M Riddell, Mike Partridge, Shreerang A Bhide, Christopher M Nutting, Kevin J Harrington, Katie L Newbold, Martin O Leach
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138545 (2015)
PURPOSE:To describe a methodology, based on cluster analysis, to partition multi-parametric functional imaging data into groups (or clusters) of similar functional characteristics, with the aim of characterizing functional heterogeneity within head a
Externí odkaz:
https://doaj.org/article/0188356f33854b9cb081b39028b4680d