Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin J Barnum"'
Autor:
Rajesh K Yadav, Carolyn M Jablonowski, Alfonso G Fernandez, Brandon R Lowe, Ryan A Henry, David Finkelstein, Kevin J Barnum, Alison L Pidoux, Yin-Ming Kuo, Jie Huang, Matthew J O’Connell, Andrew J Andrews, Arzu Onar-Thomas, Robin C Allshire, Janet F Partridge
Publikováno v:
eLife, Vol 6 (2017)
Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insigh
Externí odkaz:
https://doaj.org/article/6f07b04184fd448199fb62c77f4d0ff3
Autor:
Kevin J Barnum, Sarah A. Weiss
Publikováno v:
Cancer J
Metastatic lesions are largely responsible for cancer-related deaths and are synonymous with a poor prognosis. However, this is not always true for patients with oligometastases whose disease may be amenable to curative-intent local therapies. It has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15eda237c894a834adf99394cf3ab79
https://doi.org/10.1097/ppo.0000000000000438
https://doi.org/10.1097/ppo.0000000000000438
Publikováno v:
J Biol Chem
dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9cbd8d626b31ef5a9368549806a944
https://pubmed.ncbi.nlm.nih.gov/30885940
https://pubmed.ncbi.nlm.nih.gov/30885940
Autor:
Carolyn M Jablonowski, Janet F. Partridge, Jie Huang, Brandon R Lowe, Kevin J Barnum, Andrew J. Andrews, David Finkelstein, Alison L. Pidoux, Matthew J. O'Connell, Arzu Onar-Thomas, Rajesh K. Yadav, Alfonso G Fernandez, Robin C. Allshire, Ryan A. Henry, Yin-Ming Kuo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d276aaf5ab778e1c1c3a85323b66a44
https://doi.org/10.7554/elife.27406.025
https://doi.org/10.7554/elife.27406.025
Autor:
Matthew J. O'Connell, Kevin J Barnum
Publikováno v:
Molecular & Cellular Oncology
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3908fdd1da02ba07d0915479fc9ece6
http://europepmc.org/articles/PMC4905235
http://europepmc.org/articles/PMC4905235
Autor:
Kevin J Barnum, Matthew J. O'Connell
Publikováno v:
Methods in Molecular Biology ISBN: 9781493908875
Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f44fbb0793e4ab7d696e16977cca483
https://pubmed.ncbi.nlm.nih.gov/24906307
https://pubmed.ncbi.nlm.nih.gov/24906307