Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kevin J, Whaley"'
Autor:
Alison Schaefer, Bing Yang, Holly A. Schroeder, Dimple Harit, Mike S. Humphry, Larry Zeitlin, Kevin J. Whaley, Jacques Ravel, William A. Fischer, Samuel K. Lai
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTVaginal transmission from semen of male Ebola virus (EBOV) survivors has been implicated as a potential origin of Ebola virus disease (EVD) outbreaks. While EBOV in semen must traverse cervicovaginal mucus (CVM) to reach target cells, the beh
Externí odkaz:
https://doaj.org/article/0b91368b024b4ae7a579ea704274de58
Autor:
Ellena Nador, Chaoshuang Xia, Philip J. Santangelo, Kevin J. Whaley, Catherine E. Costello, Deborah J. Anderson
Publikováno v:
Antibodies, Vol 13, Iss 1, p 17 (2024)
IgG Fc N-glycosylation is necessary for effector functions and is an important component of quality control. The choice of antibody manufacturing platform has the potential to significantly influence the Fc glycans of an antibody and consequently alt
Externí odkaz:
https://doaj.org/article/f4115ee49a3541d4afd575326cb5cb11
Autor:
Emilie Mausser, Ellena Nador, Joseph A Politch, Michael R Pauly, Jai G Marathe, Thomas R Moench, Larry Zeitlin, Kevin J Whaley, Deborah J Anderson
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282147 (2023)
High rates of unintended pregnancies worldwide indicate a need for more accessible and acceptable methods of contraception. We have developed a monoclonal antibody, the Human Contraception Antibody (HCA), for use by women in vaginal films and rings f
Externí odkaz:
https://doaj.org/article/be5acf215cfe4c2b96bdb4513195bae6
Autor:
Kelsi Swope, Josh Morton, Gregory P. Pogue, Leigh Burden, Nicholas Partain, Steve Hume, John Shepherd, Carrie A. Simpson, Miles B. Brennan, Thomas C. Furman, Sheila Kingrey-Gebe, Theresa Martinez, Jim McDonough, Michael H. Pauly, Kevin J. Whaley, Larry Zeitlin, Barry Bratcher, Hugh Haydon
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The ongoing SARS-CoV-2 coronavirus pandemic of 2020–2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb) therapies. As reported here, a platform based on Nicotiana benthamiana produced mAb therape
Externí odkaz:
https://doaj.org/article/0444f122130744d095e196c092b78bd8
Autor:
Kevin J Whaley, Larry Zeitlin
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 2 (2022)
This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand. Increasing access to existing antibody-based products coupled with the unmet need in inf
Externí odkaz:
https://doaj.org/article/18e705d77c1c49f3b407847b94f3f1b6
Autor:
Gabriela Baldeon-Vaca, Jai G. Marathe, Joseph A. Politch, Emilie Mausser, Jeffrey Pudney, James Doud, Ellena Nador, Larry Zeitlin, Michael Pauly, Thomas R. Moench, Miles Brennan, Kevin J. Whaley, Deborah J. Anderson
Publikováno v:
EBioMedicine, Vol 69, Iss , Pp 103478- (2021)
Background: Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-grade human monoclonal antibodies (mAbs)
Externí odkaz:
https://doaj.org/article/f960369930a04b50a35050bf6a2ee689
Autor:
Joseph A Politch, Susan Cu-Uvin, Thomas R Moench, Karen T Tashima, Jai G Marathe, Kate M Guthrie, Howard Cabral, Tara Nyhuis, Miles Brennan, Larry Zeitlin, Hans M L Spiegel, Kenneth H Mayer, Kevin J Whaley, Deborah J Anderson
Publikováno v:
PLoS Medicine, Vol 18, Iss 2, p e1003495 (2021)
BackgroundMB66 film is a multipurpose prevention technology (MPT) product with monoclonal antibodies (mAbs) against HIV-1 (VRC01-N) and HSV-1 and 2 (HSV8-N). The mAbs were produced by transient expression in Nicotiana benthamiana (N). We conducted a
Externí odkaz:
https://doaj.org/article/080a0cd6780b4946ae5836420c4ae97a
Autor:
Nadja A. Vielot, Shoshana K. Goldberg, Gregory Zimet, Sara B. Smith, Mary Anne McDonald, Silvina Ramos, Karen Morgan, Chan Joo Kim, Karin L. Richter, Merce Peris, Kevin J. Whaley, Jennifer S. Smith
Publikováno v:
Papillomavirus Research, Vol 3, Iss , Pp 126-133 (2017)
Introduction: Multipurpose vaccines (MPVs) could be formulated to prevent multiple sexually transmitted infections simultaneously. Little is known about acceptability of MPVs among vaccine health care providers (HCPs) or mothers of adolescent girls.
Externí odkaz:
https://doaj.org/article/0e7edd45a1e0412ca6ee8e334417ea7b
Autor:
Andrea R. Thurman, Thomas R. Moench, Marshall Hoke, Joseph A. Politch, Howard Cabral, Emilie Mausser, Ellena Nador, Josh Morton, Krystal Hamorsky, Kelsi Swope, Barry Bratcher, Deborah J. Anderson, Kevin J. Whaley
Publikováno v:
American Journal of Obstetrics and Gynecology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a90972b82b758e750b545bf6beec626
https://doi.org/10.1016/j.ajog.2023.02.024
https://doi.org/10.1016/j.ajog.2023.02.024
Autor:
Philip J. Santangelo, Joseph A. Politch, Kevin J. Whaley, Larry Zeitlin, Samuel K. Lai, Richard A. Cone, Thomas R. Moench, Deborah J. Anderson
Publikováno v:
Biology of Reproduction
Sexually transmitted infections are highly prevalent, and over 40% of pregnancies are unplanned. We are producing new antibody-based multipurpose prevention technology products to address these problems and fill an unmet need in female reproductive h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1090c13d50a85c171c9d6c31e9ca5c
https://doi.org/10.1093/biolre/ioaa096
https://doi.org/10.1093/biolre/ioaa096