Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Kevin J, Waldron"'
Autor:
Nadia Rostami, Robert C. Shields, Hannah J. Serrage, Catherine Lawler, Jane L. Brittan, Sufian Yassin, Halah Ahmed, Achim Treumann, Paul Thompson, Kevin J. Waldron, Angela H. Nobbs, Nicholas S. Jakubovics
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Extracellular DNA (eDNA) is a key component of many microbial biofilms including dental plaque. However, the roles of extracellular deoxyribonuclease (DNase) enzymes within biofilms are poorly understood. Streptococcus gordonii is a pioneer
Externí odkaz:
https://doaj.org/article/b8132f7fb87e4172a56a6d890dc4c643
Autor:
Anna Barwinska-Sendra, Yuritzi M. Garcia, Kacper M. Sendra, Arnaud Baslé, Eilidh S. Mackenzie, Emma Tarrant, Patrick Card, Leandro C. Tabares, Cédric Bicep, Sun Un, Thomas E. Kehl-Fie, Kevin J. Waldron
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Many metalloenzymes are highly specific for their cognate metal ion but the molecular principles underlying this specificity often remain unclear. Here, the authors characterize the structural and biochemical basis for the different metal specificity
Externí odkaz:
https://doaj.org/article/6c637b09e75b4404830df194ffd54159
Autor:
Louisa J. Stewart, Cheryl-lynn Y. Ong, May M. Zhang, Stephan Brouwer, Liam McIntyre, Mark R. Davies, Mark J. Walker, Alastair G. McEwan, Kevin J. Waldron, Karrera Y. Djoko
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm, most bacteria possess a transcriptionally responsive system for Cu export. In the Gram-positive human pathogen
Externí odkaz:
https://doaj.org/article/54f175ae2c47421291edd930a86b688d
Autor:
Ping Zhang, Benrui Li, Jiaxin Mu, Dandan Liu, Guoying Zhang, Xinru Mao, Kehe Huang, Kevin J. Waldron, Xingxiang Chen
Publikováno v:
Journal of Animal Physiology and Animal Nutrition. 106:1368-1382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f98dd906913f1ff97b107332be789ca
https://doi.org/10.1111/jpn.13767
https://doi.org/10.1111/jpn.13767
Autor:
Marta Zapotoczna, Gustavo P. Riboldi, Ahmed M. Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A. Morrissey, Paul J. Planet, Matthew T. G. Holden, Kevin J. Waldron, Joan A. Geoghegan
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Pathogens are exposed to toxic levels of copper during infection, and copper tolerance may be a general virulence mechanism used by bacteria to resist host defenses. In support of this, inactivation of copper exporter genes has been found to
Externí odkaz:
https://doaj.org/article/2bf73d0d0ecc4842a392be8e865a0c11
Autor:
Young J Hong, Eilidh S Mackenzie, Samantha J Firth, Jack FR Bolton, Louisa J Stewart, Kevin J Waldron, Karrera Y Djoko
All bacteria possess homeostastic mechanisms that control the availability of micronutrient metals within the cell. Regulatory cross-talks between different metal homeostasis pathways within the same bacterial organism have been reported widely. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::419d9321663b1e090b1f66966311690c
https://doi.org/10.1101/2022.09.28.509676
https://doi.org/10.1101/2022.09.28.509676
Autor:
Yuritzi M Garcia, Anna Barwinska-Sendra, Emma Tarrant, Eric P Skaar, Kevin J Waldron, Thomas E Kehl-Fie
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006125 (2017)
Staphylococcus aureus is a devastating mammalian pathogen for which the development of new therapeutic approaches is urgently needed due to the prevalence of antibiotic resistance. During infection pathogens must overcome the dual threats of host-imp
Externí odkaz:
https://doaj.org/article/e1752d009a5c400cb1d22b1fe3541040
Autor:
Inderpreet, Kaur, Joanne, Purves, Matthew, Harwood, Julian M, Ketley, Peter W, Andrew, Kevin J, Waldron, Julie A, Morrissey
Publikováno v:
Microbiology (Reading, England). 168(4)
Bacteria have evolved mechanisms which enable them to control intracellular concentrations of metals. In the case of transition metals, such as copper, iron and zinc, bacteria must ensure enough is available as a cofactor for enzymes whilst at the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::503e5a81815853c560d7f0dd7de22a9a
https://pubmed.ncbi.nlm.nih.gov/35404222
https://pubmed.ncbi.nlm.nih.gov/35404222
Autor:
Didi He, Sam Hughes, Sally Vanden-Hehir, Atanas Georgiev, Kirsten Altenbach, Emma Tarrant, C Logan Mackay, Kevin J Waldron, David J Clarke, Jon Marles-Wright
Publikováno v:
eLife, Vol 5 (2016)
Ferritins are ubiquitous proteins that oxidise and store iron within a protein shell to protect cells from oxidative damage. We have characterized the structure and function of a new member of the ferritin superfamily that is sequestered within an en
Externí odkaz:
https://doaj.org/article/70c100118805407fa1ceccceab186068
Autor:
Jon Marles-Wright, Arnaud Baslé, David Clarke, Jennifer L. Ross, C. Logan Mackay, Kelly J. Gallagher, Will A. Stanley, Laurène Adam, Kevin J. Waldron, Didi He, Cecilia Piergentili
Publikováno v:
Piergentili, C, Ross, J, He, D, Gallagher, K J, Stanley, W A, Adam, L, Mackay, C L, Baslé, A, Waldron, K J, Clarke, D J & Marles-Wright, J 2020, ' Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.RA120.014502
J Biol Chem
J Biol Chem
Encapsulated ferritins belong to the universally distributed ferritin superfamily, whose members function as iron detoxification and storage systems. Encapsulated ferritins have a distinct annular structure and must associate with an encapsulin nanoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302e2ee6537cdfe982c8c92691d1644f
https://doi.org/10.1074/jbc.ra120.014502
https://doi.org/10.1074/jbc.ra120.014502