Zobrazeno 1 - 10
of 660
pro vyhledávání: '"Kevin J, Tracey"'
Autor:
Aisling Tynan, Téa Tsaava, Manojkumar Gunasekaran, Carlos E. Bravo Iñiguez, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Bioelectronic Medicine, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and initiate a protectiv
Externí odkaz:
https://doaj.org/article/1343afe18bba44f98cfdd995b1bea836
Autor:
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sam J. George, Tyler D. Hepler, Daniel Hide, Valentin A. Pavlov, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-10 (2023)
Abstract Background Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response activated by vagus ne
Externí odkaz:
https://doaj.org/article/637ce3daf8364f509c994bd8ab365cf4
Publikováno v:
Bioelectronic Medicine, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Background Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (ta-VNS) in patients wi
Externí odkaz:
https://doaj.org/article/f314741bc8d84202b9c27adba184e951
Autor:
Eric H. Chang, Arielle H. Gabalski, Tomas S. Huerta, Timir Datta-Chaudhuri, Theodoros P. Zanos, Stavros Zanos, Warren M. Grill, Kevin J. Tracey, Yousef Al-Abed
Publikováno v:
Bioelectronic Medicine, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory disorders. With several BEM therapies being recently approved for clinical use and others in
Externí odkaz:
https://doaj.org/article/bf9dae8608184cdb9541838584ab39b1
Autor:
Xiaoling Qiang, Weiqiang Chen, Cassie Shu Zhu, Jianhua Li, Timothy Qi, Li Lou, Ping Wang, Kevin J. Tracey, Haichao Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The pathogenic mechanisms of bacterial infections and resultant sepsis are partly attributed to dysregulated inflammatory responses sustained by some late-acting mediators including the procathepsin-L (pCTS-L). It was entirely unknown whether any com
Externí odkaz:
https://doaj.org/article/c8c00067772e467fad1081519e885c67
Autor:
Carlos E. Bravo-Iñiguez, Jason R. Fritz, Shilpa Shukla, Susmita Sarangi, Dane A. Thompson, Seema G. Amin, Tea Tsaava, Saher Chaudhry, Sara P. Valentino, Hannah B. Hoffman, Catherine W. Imossi, Meghan E. Addorisio, Sergio I. Valdes-Ferrer, Sangeeta S. Chavan, Lionel Blanc, Christopher J. Czura, Kevin J. Tracey, Jared M. Huston
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because precli
Externí odkaz:
https://doaj.org/article/067fc7beffb44e5298ec3b3aee8105af
Autor:
Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Publikováno v:
Brain Stimulation, Vol 16, Iss 3, Pp 703-711 (2023)
Focused ultrasound stimulation (FUS) activates mechanosensitive ion channels and is emerging as a method of noninvasive neuromodulation. In preclinical studies, FUS of the spleen (sFUS) activates an anti-inflammatory neural pathway which suppresses a
Externí odkaz:
https://doaj.org/article/be0515c41a95436fa5b189fda07edc16
Autor:
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sam J. George, Tyler D. Hepler, Daniel Hide, Valentin A. Pavlov, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/eb9da11fbff64479978163f9c17e973d
Autor:
Tercio Lemos de Moraes, Fernando Oliveira Costa, Danielly Gomes Cabral, Daniella Marques Fernandes, Carine Teles Sangaleti, Maria Aparecida Dalboni, Josiane Motta e Motta, Liliane Appratto de Souza, Nicola Montano, Maria Claudia Irigoyen, Michael Brines, Kevin J. Tracey, Valentin A. Pavlov, Fernanda M. Consolim Colombo
Publikováno v:
Bioelectronic Medicine, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Background There is emerging evidence that the nervous system regulates immune and metabolic alterations mediating Metabolic syndrome (MetS) pathogenesis via the vagus nerve. This study evaluated the effects of transcutaneous auricular vagus
Externí odkaz:
https://doaj.org/article/61fc94f5c3834cd99b6d997a83241f5e
Autor:
Naveen Jayaprakash, Weiguo Song, Viktor Toth, Avantika Vardhan, Todd Levy, Jacquelyn Tomaio, Khaled Qanud, Ibrahim Mughrabi, Yao-Chuan Chang, Moontahinaz Rob, Anna Daytz, Adam Abbas, Zeinab Nassrallah, Bruce T. Volpe, Kevin J. Tracey, Yousef Al-Abed, Timir Datta-Chaudhuri, Larry Miller, Mary F. Barbe, Sunhee C. Lee, Theodoros P. Zanos, Stavros Zanos
Publikováno v:
Brain Stimulation, Vol 16, Iss 2, Pp 484-506 (2023)
Vagal fibers travel inside fascicles and form branches to innervate organs and regulate organ functions. Existing vagus nerve stimulation (VNS) therapies activate vagal fibers non-selectively, often resulting in reduced efficacy and side effects from
Externí odkaz:
https://doaj.org/article/98dc21c6939945af94101697d88b381f