Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Kevin J, Barnham"'
Autor:
Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A. Perez, Céline Dubois, Yen Y. Lim, Candace Drysdale, Rebecca L. Rumble, Holly R. Chinnery, Christopher C. Rowe, Ralph N. Martins, Paul Maruff, James D. Doecke, Yong Lin, Abdel A. Belaidi, Kevin J. Barnham, Colin L. Masters, Ben J. Gu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to
Externí odkaz:
https://doaj.org/article/3d0335505eb94001ae1c6a1edbac7289
Autor:
Paul Trlin, Jenny Gong, Katie K. N. Tran, Vickie H. Y. Wong, Pei Ying Lee, Anh Hoang, Da Zhao, Leah C. Beauchamp, Jeremiah K. H. Lim, Andrew Metha, Kevin J. Barnham, David I. Finkelstein, Bang V. Bui, Phillip Bedggood, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron over
Externí odkaz:
https://doaj.org/article/4922d8416bbd4e5ca8336a9df43afadf
Autor:
Adityas Purnianto, Celeste Mawal, Mitali M. Kulkarni, Huaqi Su, Tiana F. Koukoulis, Patricia Wongsodirdjo, Ya Hui Hung, Scott Ayton, Ashley I. Bush, Kevin J. Barnham, Laura J. Vella
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 10, Pp n/a-n/a (2024)
Abstract Cells have developed a highly regulated system for the uptake, transport, utilization, storage, and export of metals, ensuring the maintenance of cellular homeostasis. Small extracellular vesicles (sEVs) function as a mechanism through which
Externí odkaz:
https://doaj.org/article/354283fce5264150957df1fa668a3d24
Autor:
Huaqi Su, Yepy H. Rustam, Colin L. Masters, Enes Makalic, Catriona A. McLean, Andrew F. Hill, Kevin J. Barnham, Gavin E. Reid, Laura J. Vella
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been made in identifying positron emission tomography and cerebrospinal fluid biomarkers for AD, but they have limit
Externí odkaz:
https://doaj.org/article/a209d645d591492fb61b11b4abc696dd
Autor:
David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A. Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare, Philip A. Doble, Simon Crawford, Elisabeth C. L. Gautier, Jack Parsons, Penny Huggins, Kevin J. Barnham, Robert A. Cherny
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/99069d05543b4502a0f195c43761709b
Autor:
Katherine A. Morgan, Michael de Veer, Luke A. Miles, Cormac A. A. Kelderman, Catriona A. McLean, Colin L. Masters, Kevin J. Barnham, Jonathan M. White, Brett M. Paterson, Paul S. Donnelly
Publikováno v:
Chemical Communications. 59:2243-2246
Amyloid-β antibodies were modified to incorporate trans-cyclooctene functional groups. Radiolabeled copper-64 probes, which can cross the blood–brain barrier and contain a 1,2,4,5-tetrazine functional group, react with the modified antibodies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcaa2022c57fab3ce056500629e54540
https://doi.org/10.1039/d2cc06850h
https://doi.org/10.1039/d2cc06850h
Autor:
Lesley Cheng, Laura J. Vella, Kevin J. Barnham, Catriona McLean, Colin L. Masters, Andrew F. Hill
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Alzheimer’s disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinical or end-stage disease. Transcriptomic deregulation of miRNA expression can spread via “horizontal” RNA transfer t
Externí odkaz:
https://doaj.org/article/cf51a9a9c3dd4c83b4d12f2d0fe555d7
Publikováno v:
Neurobiology of Stress, Vol 9, Iss , Pp 176-187 (2018)
Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is therefore a critical step towards advancing knowledge about the neurobiology of depression. Psychosocial stress has bee
Externí odkaz:
https://doaj.org/article/1ace7641c6c04fc2852ce7c0316f9b91
Autor:
Leah C. Beauchamp, Jacky Chan, Lin W. Hung, Benjamin S. Padman, Laura J. Vella, Xiang M. Liu, Bradley Coleman, Ashley I. Bush, Michael Lazarou, Andrew F. Hill, Laura Jacobson, Kevin J. Barnham
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Parkinson’s disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. Prior to diagnosis, there is a lengthy prodromal stage in which non-motor symptoms,
Externí odkaz:
https://doaj.org/article/44dfb79e8bff4f45be71e09c33c7e944
Autor:
Leah C. Beauchamp, Xiang M. Liu, Laura J. Vella, Paul A. Adlard, Ashley I. Bush, David I. Finkelstein, Kevin J. Barnham
Publikováno v:
Neurotherapeutics. 19:1966-1975
Hyposmia is a prevalent prodromal feature of Parkinson’s disease (PD), though the neuropathology that underlies this symptom is poorly understood. Unlike the substantia nigra, the status of metal homeostasis in the olfactory bulbs has not been char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997fd1657c6f22064bd734bdca96598f
https://doi.org/10.1007/s13311-022-01300-0
https://doi.org/10.1007/s13311-022-01300-0