Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kevin Inchley"'
Autor:
Kevin Inchley, James F. Lewis, Ruud A. W. Veldhuizen, Richard J. Novick, Gayatri Maitra, Fred Possmayer
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L67-L74
The effects of surfactant treatment on surfactant subtype conversion after lung injury were examined. Dogs were subjected to hyperventilation for 8 h with or without surfactant treatment. Lungs were stored for 17 h, and the right lung was transplante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28bff243cc74bf912257d5e50875a80
https://doi.org/10.1152/ajplung.2002.282.1.l67
https://doi.org/10.1152/ajplung.2002.282.1.l67
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L1179-L1189
Pulmonary surfactant stabilizes the alveoli by lining the air-fluid interface with films that reduce surface tension to near 0 mN/m (γmin). Surfactant protein B (SP-B) enhances the surface activity of surfactant phospholipids. A captive bubble tensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0214484e136ed3a876d54deffd14d6db
https://doi.org/10.1152/ajplung.1999.277.6.l1179
https://doi.org/10.1152/ajplung.1999.277.6.l1179
Structural Changes of Surfactant Protein A Induced by Cations Reorient the Protein on Lipid Bilayers
Autor:
George Harauz, Nades Palaniyar, Ross A. Ridsdale, Fred Possmayer, Kevin Inchley, Chet E. Holterman
Publikováno v:
Journal of Structural Biology. 122:297-310
Surfactant protein A (SP-A) is an octadecameric hydrophilic glycoprotein and is the major protein component of pulmonary surfactant. This protein complex plays several roles in the body, such as regulation of surfactant secretion, recycling and adsor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79e956442fbc0d640b49bca9512b4f
https://doi.org/10.1006/jsbi.1998.4004
https://doi.org/10.1006/jsbi.1998.4004
Publikováno v:
Biochimica et biophysica acta. 1440(1)
Pulmonary surfactant isolated by lavage can be separated into large aggregates (LA) and small aggregates (SA). Pulse labeling experiments have shown that the LA subtype is the precursor of the SA subtype. Conversion of LA to SA can be demonstrated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f479e6ed109e4d7abaf255dcae0281c
https://pubmed.ncbi.nlm.nih.gov/10477824
https://pubmed.ncbi.nlm.nih.gov/10477824
Publikováno v:
The American journal of physiology. 276(3)
To test the hypothesis that chronic placental insufficiency resulting in fetal growth restriction causes an increase in fetal lung surfactant-associated protein (SP) gene expression, we embolized chronically catheterized fetal sheep ( n = 6) daily us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e944e536b4501d033802d086eb78fe
https://pubmed.ncbi.nlm.nih.gov/10070110
https://pubmed.ncbi.nlm.nih.gov/10070110
Surfactant protein A inhibits T cell proliferation via its collagen-like tail and a 210-kDa receptor
Autor:
Sha Zhu, Zissis C. Chroneos, Francis X. McCormack, Kevin Inchley, Baher M. Elhalwagi, Paul Borron, Laurence J. Fraher, Virginia L. Shepherd, Fred Possmayer, James F. Lewis, Jo Rae Wright
Publikováno v:
The American journal of physiology. 275(4)
Investigation of possible mechanisms to describe the hyporesponsiveness of pulmonary leukocytes has led to the study of pulmonary surfactant and its constituents as immune suppressive agents. Pulmonary surfactant is a phospholipid-protein mixture tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cf7072b291a6dd838055da7ffff017
https://pubmed.ncbi.nlm.nih.gov/9755099
https://pubmed.ncbi.nlm.nih.gov/9755099
Autor:
Jennifer Stewart, Surapon Pattanajitvilai, Kevin Inchley, Francis X. McCormack, Fred Possmayer, D R Voelker
Publikováno v:
The Journal of biological chemistry. 272(44)
Rat pulmonary surfactant protein A is an oligomer of 18 polypeptide chains which are associated by triple helix formation in the collagen-like domain and interchain disulfide bridges at the NH2 terminus. The roles of the intermolecular bond at Cys6 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123a388b5af71ee15700e7da53edae27
https://pubmed.ncbi.nlm.nih.gov/9346948
https://pubmed.ncbi.nlm.nih.gov/9346948
Autor:
James F. Lewis, Fred Possmayer, R G McFadden, Ruud A. W. Veldhuizen, Anita Caveney, Laurence J. Fraher, Paul Borron, Kevin Inchley
Publikováno v:
ResearcherID
The hyporesponsive state of lung-derived mononuclear leukocytes has been, in part, attributed to the effects of the lipid rather than the protein components of pulmonary surfactant. In the present study, however, the results suggest that purified pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8ef046e9bd58e219ec55d0da318e48
https://pubmed.ncbi.nlm.nih.gov/8679215
https://pubmed.ncbi.nlm.nih.gov/8679215
Publikováno v:
The Biochemical journal. 295
Pulmonary surfactant obtained from lung lavages can be separated by differential centrifugation into two distinct subfractions known as large surfactant aggregates and small surfactant aggregates. The large-aggregate fraction is the precursor of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c089b4788d7441d4aa1d55d13ef8aee
https://pubmed.ncbi.nlm.nih.gov/8216208
https://pubmed.ncbi.nlm.nih.gov/8216208
Autor:
Anita Rigaux, Shabih U Hasan, Sam Schurch, Kevin Inchley, Fred Possmayer, Jonathan Langridge, Ather Bano
Publikováno v:
Pediatric Research. 43:333-333
We have previously shown that fetal lambs which have undergone intrathoracic vagal denervation have increased surface tension and develop respiratory failure at birth. However, the mechanism of surfactant dysfunction remains unknown. To quantify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d982f1afee9c847c55e5ad0ecbe6c230
https://doi.org/10.1203/00006450-199804001-01974
https://doi.org/10.1203/00006450-199804001-01974