Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kevin Hudson"'
Autor:
Larissa S. Carnevalli, Charles Sinclair, Molly A. Taylor, Pablo Morentin Gutierrez, Sophie Langdon, Anna M. L. Coenen-Stass, Lorraine Mooney, Adina Hughes, Laura Jarvis, Anna Staniszewska, Claire Crafter, Ben Sidders, Elizabeth Hardaker, Kevin Hudson, Simon T. Barry
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kδ modul
Externí odkaz:
https://doaj.org/article/d8dfe19702e54dfe8e8186c3eeb57177
Autor:
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α o
Externí odkaz:
https://doaj.org/article/b4e5424c728540eebddd9be828dbc15c
Autor:
Juliana Maynard, Sally-Ann Emmas, Francois-Xavier Ble, Herve Barjat, Emily Lawrie, Urs Hancox, Urszula M Polanska, Alison Pritchard, Kevin Hudson
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183048 (2017)
The phosphatidyl inositol 3 kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) signal transduction pathway is frequently de-regulated and activated in human cancer and is an important therapeutic target. AZD8835 is a PI3K inhibitor, with sel
Externí odkaz:
https://doaj.org/article/80f605b879c64cb1be9488d813ac5c25
Autor:
Panagiotis Kasteridis, Andrew Street, Matthew Dolman, Lesley Gallier, Kevin Hudson, Jeremy Martin, Ian Wyer
Publikováno v:
International Journal of Integrated Care, Vol 15, Iss 1 (2015)
Aims: The Symphony Project is designed to identify which groups of the South Somerset population in England would most benefit from greater integration across primary, community, acute and social care settings. Methods: We analysed linked health and
Externí odkaz:
https://doaj.org/article/f20d01da790044789deb7eeb964930e5
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Tumor cell line panel composition and growth inhibition sensitivity (GI50) to AZD8835.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4782fd316b02ec8951d691e4f7122f
https://doi.org/10.1158/1535-7163.22507675.v1
https://doi.org/10.1158/1535-7163.22507675.v1
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Details on PK / PD / efficacy modeling in BT474 xenograft model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c1af759ac8bbaffa0a90dd3c7be5a7
https://doi.org/10.1158/1535-7163.22507681
https://doi.org/10.1158/1535-7163.22507681
Autor:
Pierre Laurent-Puig, Jonathan Derry, Stephen Friend, Jean-Charles Soria, Michel Ducreux, Brian Dougherty, Erich Huang, Kevin Hudson, Claus Bendtsen, Kai-Ming Chang, KJ Kao, Gilles Manceau, Robert McEwen, Jonathan Dry, Charles Ferté, Justin Guinney
PDF file - 35K, Characteristics of the 2 metastatic CRC datasets used for evaluation of prediction of PFS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642aff6c3c1cd688be8ef7081c6492fc
https://doi.org/10.1158/1078-0432.22448667.v1
https://doi.org/10.1158/1078-0432.22448667.v1
Autor:
Pierre Laurent-Puig, Jonathan Derry, Stephen Friend, Jean-Charles Soria, Michel Ducreux, Brian Dougherty, Erich Huang, Kevin Hudson, Claus Bendtsen, Kai-Ming Chang, KJ Kao, Gilles Manceau, Robert McEwen, Jonathan Dry, Charles Ferté, Justin Guinney
PDF file - 32K, PFS analysis within the French cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7625bc63e8625908c79d3445ae401b93
https://doi.org/10.1158/1078-0432.22448655
https://doi.org/10.1158/1078-0432.22448655
Autor:
Pierre Laurent-Puig, Jonathan Derry, Stephen Friend, Jean-Charles Soria, Michel Ducreux, Brian Dougherty, Erich Huang, Kevin Hudson, Claus Bendtsen, Kai-Ming Chang, KJ Kao, Gilles Manceau, Robert McEwen, Jonathan Dry, Charles Ferté, Justin Guinney
PDF file - 33K, Univariate analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152e2991c6ecd794e540d2321f757832
https://doi.org/10.1158/1078-0432.22448658.v1
https://doi.org/10.1158/1078-0432.22448658.v1
Autor:
Pierre Laurent-Puig, Jonathan Derry, Stephen Friend, Jean-Charles Soria, Michel Ducreux, Brian Dougherty, Erich Huang, Kevin Hudson, Claus Bendtsen, Kai-Ming Chang, KJ Kao, Gilles Manceau, Robert McEwen, Jonathan Dry, Charles Ferté, Justin Guinney
PDF file - 219K, Supplemental Figure 1. A We evaluated 4 "RAS" signatures across 4 CRC data sets to assess their ability to discriminate KRAS mutant samples from KRAS wild-type. Supplemental Figure 2. The lower observed RIS of KRAS codon 13 mutated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7c3bf2c4346c5faa8b9fdc6a2e308
https://doi.org/10.1158/1078-0432.22448673.v1
https://doi.org/10.1158/1078-0432.22448673.v1