Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kevin Hou"'
Publikováno v:
Contemporary Clinical Trials Communications, Vol 40, Iss , Pp 101329- (2024)
Background: Traditional dose selection for oncology registration trials typically employs a one- or two-step single maximum tolerated dose (MTD) approach. However, this approach may not be appropriate for molecularly targeted therapy, which tends to
Externí odkaz:
https://doaj.org/article/cf6b9d3798e44c5bb59d9d76b7beb11d
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions and/or transfusions. W
Externí odkaz:
https://doaj.org/article/c1e4853079f34cbdaed6a9784ed19fde
Publikováno v:
ACS Macro Letters. 10:545-550
The spontaneous ordering of block polymers doped with ions is affected by both selective solvation and long-range Coulombic interaction. The mean-field treatment was recently shown to overestimate the solvation-induced ordering, requiring a large sol
Autor:
Annie Im, Daniel Wolff, Corey Cutler, Robert Zeiser, Nirav N. Shah, Ming Tony Tan, Jaime Sanz, Haris Ali, Giuseppe Milone, Arjun D. Law, Domenico Russo, Eva-Maria Wagner, Olga Ivanova, Kevin Hou, Maureen Bleam, Rodica Morariu-Zamfir, Steven Z Pavletic
Publikováno v:
Blood. 140:1870-1871
Publikováno v:
International journal of cancerREFERENCES. 151(9)
Identifying the maximum tolerated dose (MTD) and recommending a Phase II dose for an investigational treatment is crucial in cancer drug development. A suboptimal dose often leads to a failed late-stage trial, while an overly toxic dose causes harm t
Autor:
Lindsey B. Cundra, Manasa Vallabhaneni, Kevin Houston, Michael Saadeh, Alejandra Vargas, Steven M. D’Souza, David A. Johnson
Publikováno v:
Exploration of Immunology, Vol 4, Iss 1, Pp 90-105 (2024)
The intestinal mucosal barrier plays a critical role in maintaining the integrity of the gastrointestinal (GI) tract and protecting the body from harmful toxins and pathogens. Nutrition additionally serves as a vital component in maintaining bodily h
Externí odkaz:
https://doaj.org/article/2a17e752bf6e44b7b1e812a12af78f4f
Publikováno v:
Macromolecules, vol 53, iss 10
The effects of salt-doping on the morphological behavior of block copolymers are well established but remain poorly understood, partially because of the challenge of resolving electrostatics in a heterogeneous medium with low average permittivity. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f38c8633146433a74c94634d3b6723
https://escholarship.org/uc/item/81f3824s
https://escholarship.org/uc/item/81f3824s
Publikováno v:
Macromolecules. 51:7463-7475
The phase behavior of ion-containing block copolymers is studied using a field-theoretic model consisting of fully mobile ions immersed in a heterogeneous dielectric medium. Two distinct thermodynamic regimes are found to emerge, resulting from the c
Autor:
Nina Rønsted, Rhian Campbell, Mike DeMotta, Merlin Edmonds, Kevin Houck, Matthew Kahokuloa Jr, Kimberley K. Mayfield, Ben Nyberg, Mike Opgenorth, Seana K. Walsh, Dustin Wolkis, Kenneth R. Wood, Uma Nagendra
Publikováno v:
Plants, People, Planet, Vol 5, Iss 4, Pp 547-562 (2023)
Societal Impact Statement Trees are an important part of many ecosystems. The Global Tree Assessment data can be used to focus conservation and restoration efforts for the circa 30% of tree species that are threatened worldwide. The conservation stat
Externí odkaz:
https://doaj.org/article/f2204816859b45e3a2e313011c8a5280
Publikováno v:
Abstracts Accepted for Publication.
Background T cells express muscarinic and nicotinic acetylcholine receptors (mAChRs, nAChRs) that increase intracellular Ca2+ [1] on stimulation. The expression of these receptors on macrophages and their activation by vagal stimulation has recently