Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kevin Hickling"'
Autor:
Leda Mirbahai, Angela Mally, Kevin Hickling, Carolin Hamberger, Tim D. Williams, Tao Chen, J. Kevin Chipman
Publikováno v:
Toxicology. 292:63-70
Furan, a widely used industrial compound, has been found in a number of heated food items. Furan is carcinogenic to rats and mice, but the mechanism behind its carcinogenic effect is still not well understood. In this study, we tested the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cd3820fd240986b51ec0a1df1a127e
https://doi.org/10.1016/j.tox.2011.10.020
https://doi.org/10.1016/j.tox.2011.10.020
Autor:
Frida Gustafsson, Philip A. MacFaul, Simon Brocklehurst, Kevin Hickling, James Goodman, Ryan A. Bragg, Steve Swallow, Jonathan Tugwood
Publikováno v:
Chemical research in toxicology. 28(10)
The oral dipeptidyl peptidase 1 (DPP1) inhibitor AZD5248 showed aortic binding in a rat quantitative whole-body autoradiography (QWBA) study, and its development was terminated prior to human dosing. A mechanistic hypothesis for this finding was esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0889177eddd9e0525408470fad2dcc88
https://pubmed.ncbi.nlm.nih.gov/26351880
https://pubmed.ncbi.nlm.nih.gov/26351880
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039caecc0852bb3bd72abf0265b59ccf
https://doi.org/10.1038/ncomms7715
https://doi.org/10.1038/ncomms7715
Autor:
Maureen Hattersley, John Pederson, Matt Wagoner, Pete Newham, Janet Kelsal, Natalie Keirstead, Kevin Hickling, Jayne Harris, Dan Heathcote
Publikováno v:
Toxicology Letters. 229:S75-S76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a30dc301ff4a512800f7d1782aff811
https://doi.org/10.1016/j.toxlet.2014.06.293
https://doi.org/10.1016/j.toxlet.2014.06.293
Publikováno v:
Toxicologic pathology. 38(2)
Cholangiofibrosis is a structural anomaly that precedes the development of cholangiocarcinoma in some rodent models. In this article, the authors examine the contribution of the epithelial and mesenchymal cells in the pathogenesis of this complex les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2409dd41f6c5384d45faa2d0814181eb
https://pubmed.ncbi.nlm.nih.gov/20231548
https://pubmed.ncbi.nlm.nih.gov/20231548
Autor:
T.G. Hammond, Angela Mally, J. G. Evans, James K. Chipman, Victor I. C. Oreffo, J. M. Hitchcock, Kevin Hickling
Publikováno v:
Toxicologic pathology. 38(2)
Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have investigated the potential of furan to induce oxidative stress and DNA damage associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9ece5d079089f65f7b5cc13051fbc5
https://pubmed.ncbi.nlm.nih.gov/20124500
https://pubmed.ncbi.nlm.nih.gov/20124500
Publikováno v:
Toxicology Letters. 189:S41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11eaea0924062a69369f1b5270e4fde
https://doi.org/10.1016/j.toxlet.2009.06.129
https://doi.org/10.1016/j.toxlet.2009.06.129
Publikováno v:
Toxicology Letters. 189:S137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39230bce6a4982beff70a00f296fef55
https://doi.org/10.1016/j.toxlet.2009.06.725
https://doi.org/10.1016/j.toxlet.2009.06.725
Autor:
Ryan A. Bragg, Simon Brocklehurst, Frida Gustafsson, James Goodman, Kevin Hickling, Philip A. MacFaul, Steve Swallow, Jonathan Tugwood
Publikováno v:
Chemical Research in Toxicology; Oct2015, Vol. 28 Issue 10, p1991-1999, 9p
Publikováno v:
Toxicology Letters. 144:s99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ade8c912c0c25751dbcde57c6cdb20
https://doi.org/10.1016/s0378-4274(03)90365-1
https://doi.org/10.1016/s0378-4274(03)90365-1