Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kevin Hestir"'
Autor:
James Hnatyszyn, Maike Schmidt, Khushboo Sharma, Kevin Hestir, Nerissa Mendoza, Janine Powers
Publikováno v:
Molecular Cancer Therapeutics. 18:A033-A033
Background: Gastric cancer is the third leading cause of global cancer-related death, with 782,685 deaths in 2018 (Jemal, A. et al. 2018). Currently available treatments have limited benefits. Hence there’s a pressing need for more effective treatm
Autor:
Muhammad Shaalan Beg, Penny Phillips, Dimple Pandya, Zev A. Wainberg, Kevin Hestir, Serena Perna, James J. Lee, Michael Carleton, Sandeep P. Inamdar, Shih-Min A. Huang, Sarina Anne Piha-Paul, Ke Xu, Osama E. Rahma, Ernestine Lee, Janine Powers
Publikováno v:
Journal of Clinical Oncology. 36:3020-3020
3020Background: Colony stimulating factor 1 receptor (CSF-1R) signaling supports recruitment, development, and maintenance of immune suppressive macrophages within the tumor. Combining anti–CSF-1R ...
Autor:
Kevin Hestir, Amy W. Hsu, Hongbing Zhang, Aileen Zhou, Elizabeth Bosch, W. Michael Kavanaugh, Brian Wong, Lewis T. Williams, Lily Pao, Ernestine Lee, Gang Wang, Haixia Liu, Thomas L. Bray, Robert Halenbeck, Arthur Brace
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(44)
There are many transmembrane receptor-like proteins whose ligands have not been identified. A strategy for finding ligands when little is known about their tissue source is to screen each extracellular protein individually expressed in an array forma
Publikováno v:
Water Resources Research. 34:3335-3347
We present a method for inverse modeling in hydrology that incorporates a physical understanding of the geological processes that form a hydrologic system. The method is based on constructing a stochastic model that is approximately representative of
Autor:
Kevin Hestir
Publikováno v:
Journal of Computational and Graphical Statistics. 7:77-91
Consider a realization of a stochastic process X and a noisy measurement M of a function of that process. We give a general method, called conditional coding, for sampling from the conditional distribution of X given M. The main idea is to apply Mark
Autor:
Lewis T. Williams, James Zanghi, Amy W. Hsu, Namrata Patil, Thomas Brennan, Servando Palencia, Li Long, Kevin P. Baker, Deborah H. Charych, Diane Hollenbaugh, Stephen Doberstein, Minmin Qin, Robert Halenbeck, Shannon Marshall, Thomas Harding, Hongbing Zhang, W. Michael Kavanaugh, Kevin Hestir, Ali Sadra, Anita Levin
Publikováno v:
Science translational medicine. 5(178)
The fibroblast growth factor (FGF) pathway promotes tumor growth and angiogenesis in many solid tumors. Although there has long been interest in FGF pathway inhibitors, development has been complicated: An effective FGF inhibitor must block the activ
Autor:
Stephen J. Martel, Jane O. S. Long, Junming Yang, James Evans, Kevin Hestir, Pete D'Onfro, William Rizer
Publikováno v:
Flow and Transport through Unsaturated Fractured Rock
We present a method that links physical theory for the origin of a fracture system to field observations. The method generates simulations of a physically-based stochastic model that are conditioned on field observations. Two examples using stochasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26016f64ab1a9656cb7f0970e532f9e
https://doi.org/10.1029/gm042p0061
https://doi.org/10.1029/gm042p0061
Autor:
Arthur Brace, Servando Palencia, Artur Karasyov, Ernestine Lee, Brian Wong, Luis Borges, Nathan Sallee, Ryan Liang, Jacqueline de la Torre, Thomas Brennan, David I. Bellovin, Kevin Hestir
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Antibody blockade of immune checkpoint regulators such as PD-1 and CTLA4 has been shown to be an effective cancer treatment strategy; however, a large percentage of patients still do not respond to existing therapies. Discovery of a
Autor:
Ernestine Lee, David I. Bellovin, Nebiyu Wondyfraw, Kevin Hestir, Servando Palencia, Jacqueline de la Torre, Thomas Brennan
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Identification of novel targets in cancer immunotherapy is needed to address the significant number of patients that either do not respond to current therapies or encounter unacceptable toxicities. The discovery of such targets, inc
Publikováno v:
Water Resources Research. 30:1721-1745
One way to estimate the hydrologic properties of heterogeneous geologic media is to invert well test data using multiple observation wells. Pressure transients observed during a well test are compared to the corresponding values obtained by numerical