Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kevin Heebøll Nygaard"'
Autor:
Andreas Kristian Pedersen, Kevin Heebøll Nygaard, Sofie Ronja Petersen, Kirsten Specht, Thomas Strøm, Caroline Margaret Moos, Helene Skjøt-Arkil, Jesper Ougaard Schønnemann
Publikováno v:
Contemporary Clinical Trials Communications, Vol 36, Iss , Pp 101228- (2023)
Background: The elderly population is expanding globally. This gives numerous challenges especially regarding hip fracture patients. In the US alone over 300.000 hip fracture patients are treated each year, and a large amount of those develop opoid a
Externí odkaz:
https://doaj.org/article/0c3fa6054eaa4162a3a554a5ef0e3177
Autor:
Frantz Rom Poulsen, Troels Halfeld Nielsen, Jan Bert Gramsbergen, Carl-Henrik Nordström, Kevin Heebøll Nygaard, Jesper F. Havelund, Nils J. Færgeman, Axel Forsse
Publikováno v:
Metabolites
Volume 10
Issue 7
Nygaard, K H, Havelund, J F, Nielsen, T H, Nordström, C H, Færgeman, N J, Poulsen, F R, Gramsbergen, J B & Forsse, A 2020, ' Ethyl pyruvate increases post-ischemic levels of mitochondrial energy metabolites : A 13 c-labeled cerebral microdialysis study ', Metabolites, vol. 10, no. 7, 287 . https://doi.org/10.3390/metabo10070287
Metabolites, Vol 10, Iss 287, p 287 (2020)
Volume 10
Issue 7
Nygaard, K H, Havelund, J F, Nielsen, T H, Nordström, C H, Færgeman, N J, Poulsen, F R, Gramsbergen, J B & Forsse, A 2020, ' Ethyl pyruvate increases post-ischemic levels of mitochondrial energy metabolites : A 13 c-labeled cerebral microdialysis study ', Metabolites, vol. 10, no. 7, 287 . https://doi.org/10.3390/metabo10070287
Metabolites, Vol 10, Iss 287, p 287 (2020)
Mitochondrial dysfunction after transient cerebral ischemia can be monitored by cerebral microdialysis (CMD) using changes in the lactate and pyruvate concentrations and ratio. Other metabolites associated with mitochondrial (dys)function are, e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5a1fc6c05b4257b79ff0dee0e336b8
Autor:
Troels Halfeld Nielsen, Jan Bert Gramsbergen, Carl-Henrik Nordström, Frantz Rom Poulsen, Kevin Heebøll Nygaard, Axel Forsse, Nils J. Færgeman, Jesper F. Havelund
Publikováno v:
Metabolites, Vol 9, Iss 10, p 204 (2019)
Metabolites
Volume 9
Issue 10
Havelund, J F, Nygaard, K H, Nielsen, T H, Nordström, C-H, Poulsen, F R, Færgeman, N J, Forsse, A & Gramsbergen, J B 2019, ' In Vivo Microdialysis of Endogenous and 13C-labeled TCA Metabolites in Rat Brain : Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia ', Metabolites, vol. 9, no. 10, 204 . https://doi.org/10.3390/metabo9100204
Metabolites
Volume 9
Issue 10
Havelund, J F, Nygaard, K H, Nielsen, T H, Nordström, C-H, Poulsen, F R, Færgeman, N J, Forsse, A & Gramsbergen, J B 2019, ' In Vivo Microdialysis of Endogenous and 13C-labeled TCA Metabolites in Rat Brain : Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia ', Metabolites, vol. 9, no. 10, 204 . https://doi.org/10.3390/metabo9100204
Cerebral micro-dialysis allows continuous sampling of extracellular metabolites, including glucose, lactate and pyruvate. Transient ischemic events cause a rapid drop in glucose and a rise in lactate levels. Following such events, the lactate/pyruvat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ff20c8a74a61afebeb4fc133ac9397
https://www.mdpi.com/2218-1989/9/10/204
https://www.mdpi.com/2218-1989/9/10/204
Autor:
Kevin Heebøll Nygaard, Jan Bert Gramsbergen, Troels Halfeld Nielsen, Frantz Rom Poulsen, Jesper F. Havelund, Carl-Henrik Nordström, Axel Forsse, Nils J. Færgeman
Publikováno v:
Stroke. 50
Introduction: Metabolic perturbations associated with mitochondrial function are common after transient cerebral ischemia and are detectable using cerebral microdialysis (CMD). Several putative neuroprotective treatments including ethyl pyruvate (EP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1a84231fae7324be323e5bea4bb412
https://doi.org/10.1161/str.50.suppl_1.tp318
https://doi.org/10.1161/str.50.suppl_1.tp318
Autor:
Carl-Henrik Nordström, Jan Bert Gramsbergen, Kevin Heebøll Nygaard, Frantz Rom Poulsen, Troels Halfeld Nielsen, Axel Forsse
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Forsse, A, Nielsen, T H, Nygaard, K H, Nordström, C-H, Gramsbergen, J B & Poulsen, F R 2019, ' Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia ', Scientific Reports, vol. 9, no. 1, 3702 . https://doi.org/10.1038/s41598-019-40245-x
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Forsse, A, Nielsen, T H, Nygaard, K H, Nordström, C-H, Gramsbergen, J B & Poulsen, F R 2019, ' Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia ', Scientific Reports, vol. 9, no. 1, 3702 . https://doi.org/10.1038/s41598-019-40245-x
Cerebral microdialysis can be used to detect mitochondrial dysfunction, a potential target of neuroprotective treatment. Cyclosporin A (CsA) is a mitochondrial stabiliser that in a recent clinical stroke trial showed protective potential in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72edf215880dfd52c1ecf42488e73229
https://pubmed.ncbi.nlm.nih.gov/30842488
https://pubmed.ncbi.nlm.nih.gov/30842488