Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kevin Haub"'
Autor:
Estienne C Swart, John R Bracht, Vincent Magrini, Patrick Minx, Xiao Chen, Yi Zhou, Jaspreet S Khurana, Aaron D Goldman, Mariusz Nowacki, Klaas Schotanus, Seolkyoung Jung, Robert S Fulton, Amy Ly, Sean McGrath, Kevin Haub, Jessica L Wiggins, Donna Storton, John C Matese, Lance Parsons, Wei-Jen Chang, Michael S Bowen, Nicholas A Stover, Thomas A Jones, Sean R Eddy, Glenn A Herrick, Thomas G Doak, Richard K Wilson, Elaine R Mardis, Laura F Landweber
Publikováno v:
PLoS Biology, Vol 11, Iss 1, p e1001473 (2013)
The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic variation. During sexual genome development, the expressed, somatic macronuclear genome is whittled down t
Externí odkaz:
https://doaj.org/article/2c997db6921e48499101458b87b25641
Autor:
Tabbetha D. Lopez, Aliye B. Cepni, Lenora P. Goodman, Katherine R. Arlinghaus, Margit Wiesner, Craig A. Johnston, Kevin Haubrick, Tracey A. Ledoux
Publikováno v:
Nutrition Journal, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Disordered eating behaviors and body dissatisfaction are highly prevalent among adolescents and linked to negative health outcomes. While Hispanic adolescents appear to be at high risk of disordered eating and body dissatisfaction
Externí odkaz:
https://doaj.org/article/e9f8629c20c34ec6887133d5c486cf7c
Autor:
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter, Hirotake Furihata, Darren Darren, Sarath Ramachandran, Sohini Chakraborti, Kevin Haubrich, Julie Pethe, Denzel Gonzales, Andre J. Wijaya, Maria Rodriguez-Rios, Manon Sturbaut, Dylan M. Lynch, William Farnaby, Mark A. Nakasone, David Zollman, Alessio Ciulli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural inv
Externí odkaz:
https://doaj.org/article/70479f877d614c148e6f8203f19d4b2d
Autor:
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut
Externí odkaz:
https://doaj.org/article/d8245675d28e4b2bbc482fdb79f08563
Autor:
Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-li
Externí odkaz:
https://doaj.org/article/8bf42e914ed440c3a94fb07330693da9
Autor:
Laura F. Landweber, Vincent Magrini, Yi Zhou, Thomas A. Jones, Klaas Schotanus, John R. Bracht, Sean R. Eddy, Seolkyoung Jung, Elaine R. Mardis, Mariusz Nowacki, Jaspreet S. Khurana, Donna Storton, Jessica L. Wiggins, Kevin Haub, Aaron David Goldman, Glenn Herrick, Michael S. Bowen, Wei-Jen Chang, Richard K. Wilson, Patrick Minx, Xiao Chen, Lance Parsons, Robert S. Fulton, Nicholas A. Stover, John C. Matese, Thomas G. Doak, Estienne C. Swart, Amy Ly, Sean McGrath
Publikováno v:
PLoS Biology
PLoS Biology, Vol 11, Iss 1, p e1001473 (2013)
Swart, Estienne C.; Bracht, John R.; Magrini, Vincent; Minx, Patrick; Chen, Xiao; Zhou, Yi; Khurana, Jaspreet S.; Goldman, Aaron D.; Nowacki, Mariusz; Schotanus, Klaas; Jung, Seolkyoung; Fulton, Robert S.; Ly, Amy; McGrath, Sean; Haub, Kevin; Wiggins, Jessica L.; Storton, Donna; Matese, John C.; Parsons, Lance; Chang, Wei-Jen; ... (2013). The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes. PLoS biology, 11(1), e1001473. Public Library of Science 10.1371/journal.pbio.1001473
PLoS Biology, Vol 11, Iss 1, p e1001473 (2013)
Swart, Estienne C.; Bracht, John R.; Magrini, Vincent; Minx, Patrick; Chen, Xiao; Zhou, Yi; Khurana, Jaspreet S.; Goldman, Aaron D.; Nowacki, Mariusz; Schotanus, Klaas; Jung, Seolkyoung; Fulton, Robert S.; Ly, Amy; McGrath, Sean; Haub, Kevin; Wiggins, Jessica L.; Storton, Donna; Matese, John C.; Parsons, Lance; Chang, Wei-Jen; ... (2013). The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes. PLoS biology, 11(1), e1001473. Public Library of Science 10.1371/journal.pbio.1001473
With more chromosomes than any other sequenced genome, the macronuclear genome of Oxytricha trifallax has a unique and complex architecture, including alternative fragmentation and predominantly single-gene chromosomes.
The macronuclear genome o
The macronuclear genome o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf977c20f3f916a10d34724c67c644ff
http://europepmc.org/articles/PMC3558436
http://europepmc.org/articles/PMC3558436
Autor:
Marios G. Koliopoulos, Mathilde Lethier, Annemarthe G. van der Veen, Kevin Haubrich, Janosch Hennig, Eva Kowalinski, Rebecca V. Stevens, Stephen R. Martin, Caetano Reis e Sousa, Stephen Cusack, Katrin Rittinger
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition
Externí odkaz:
https://doaj.org/article/37466ebb4272497c9f39f54fcc779957
Autor:
Lukas P. Feilen, Kevin Haubrich, Paul Strecker, Sabine Probst, Simone Eggert, Gunter Stier, Irmgard Sinning, Uwe Konietzko, Stefan Kins, Bernd Simon, Klemens Wild
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds
Externí odkaz:
https://doaj.org/article/1f8fb131998b4e0886bb287a66fd4d8a
Autor:
Nay Thane, George M. Weinstock, Kevin Haub, Wesley C. Warren, Jason R. Miller, Richard K. Wilson, Patrick Minx, Liang Ye, Makedonka Mitreva, LaDeana W. Hillier, Elaine R. Mardis, David J. Dooling, Lei Chen, Devin P. Locke, John Martin
Publikováno v:
Genome Biology
The unparalleled efficiency of next-generation sequencing (NGS) has prompted widespread adoption, but significant problems remain in the use of NGS data for whole genome assembly. We explore the advantages and disadvantages of chicken genome assembli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7523acd54e4635111209f38048203e