Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kevin Hammon"'
Autor:
Kevin Hammon, Greg deHart, Brian R. Vuillemenot, Derek Kennedy, Don Musson, Charles A. O’Neill, Martin L. Katz, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1810-1821 (2021)
Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an ultra‐rare pediatric neurodegenerative disorder characterized by deficiency of the lysosomal enzyme tripeptidyl peptidase‐1 (TPP1). In the absence of adequate TPP1, lysosomal sto
Externí odkaz:
https://doaj.org/article/0b3f82eee32841929b398938b7d967e2
Autor:
Aryun Kim, Anita Grover, Kevin Hammon, Greg deHart, Peter Slasor, Anu Cherukuri, Temitayo Ajayi, David Jacoby, Angela Schulz, Nicola Specchio, Emily deLos Reyes, Paul Gissen, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 635-644 (2021)
Cerliponase alfa is recombinant human tripeptidyl peptidase 1 (TPP1) delivered by i.c.v. infusion for CLN2, a pediatric neurodegenerative disease caused by deficiency in lysosomal enzyme TPP1. We report the pharmacokinetics (PK) and pharmacodynamics
Externí odkaz:
https://doaj.org/article/afb882a5970146d6bafd1acb5b2b22cf
Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer
Autor:
Fan Yang, Wing Yen Wong, Stephen J. Zoog, Hassibullah Akeefe, Elli Koziol, Christian Vettermann, Jennifer Holcomb, Annie Clark, Kevin Hammon, Joshua Henshaw, Nina Mitchell, Kathryn Patton, Krystal Sandza, Benjamin Kim
Publikováno v:
Gene Therapy. 29:94-105
Adeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release into the environment. In studies with AAV5-FVIII-SQ (valoctocogene roxaparvovec), an investigational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ba614012286642560de73bd2c68659
https://doi.org/10.1038/s41434-021-00287-1
https://doi.org/10.1038/s41434-021-00287-1
Autor:
Martin L. Katz, Brian R. Vuillemenot, Greg de Hart, Don Musson, Joshua Henshaw, Charles A. O'Neill, Derek Kennedy, Kevin Hammon
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 5, Pp 1810-1821 (2021)
Clinical and Translational Science, Vol 14, Iss 5, Pp 1810-1821 (2021)
Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an ultra‐rare pediatric neurodegenerative disorder characterized by deficiency of the lysosomal enzyme tripeptidyl peptidase‐1 (TPP1). In the absence of adequate TPP1, lysosomal storage mate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b9f7df12c1312cc9482204d3472724
https://pubmed.ncbi.nlm.nih.gov/34076336
https://pubmed.ncbi.nlm.nih.gov/34076336
Autor:
Kevin Hammon, Benjamin Kim, Chris B. Russell, Annie Clark, Joshua Henshaw, Jennifer Holcomb, Kala Jayaram, Elli Koziol, Krystal Sandza, Christian Vettermann, Richard Torres
Publikováno v:
Blood. 136:21-21
Introduction: Long-term durable expression of hFVIII-SQ has been observed following BMN 270 (AAV5-hFVIII-SQ, valoctocogene roxaparvovec) single-dose administration in patients with severe hemophilia A. Although adeno-associated virus (AAV) vectors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff3be65680f5859678fe26081a26f4fe
https://doi.org/10.1182/blood-2020-136459
https://doi.org/10.1182/blood-2020-136459
Publikováno v:
Journal of Glaciology, Vol 67, Pp 49-57 (2021)
Effective snow grain radius (re) is mapped at high resolution using near-infrared hyperspectral imaging (NIR-HSI). The NIR-HSI method can be used to quantify re spatial variability, change in re due to metamorphism, and visualize water percolation in
Externí odkaz:
https://doaj.org/article/5e8bb755436542ae93395716711012ff
Autor:
Christopher Donahue, Kevin Hammonds
Publikováno v:
Remote Sensing, Vol 14, Iss 10, p 2297 (2022)
The infiltration of liquid water in a seasonal snowpack is a complex process that consists of two primary mechanisms: a semi-uniform melting front, or matrix flow, and heterogeneous preferential flow paths. Distinguishing between these two mechanisms
Externí odkaz:
https://doaj.org/article/ce220f6fabfe431cb831fc7936a2e71d
Autor:
Seyed Hossein Haeri, Peter Thompson, Neil Davies, Peter Van Roy, Kevin Hammond, James Chapman
Publikováno v:
Computers, Vol 11, Iss 3, p 45 (2022)
This paper directly addresses a long-standing issue that affects the development of many complex distributed software systems: how to establish quickly, cheaply, and reliably whether they can deliver their intended performance before expending signif
Externí odkaz:
https://doaj.org/article/4deab28fc5d641a5a4d0fb4b1d14aa53
Autor:
KEVIN HAMMONDS, IAN BAKER
Publikováno v:
Journal of Glaciology, Vol 62, Pp 954-962 (2016)
Recent studies have suggested a physical link between Ca++ ions and an increase in the ductility or ‘softening’ of polycrystalline ice. In order to investigate the potential effects of Ca++ on deformation, we created sets of both undoped and CaSO
Externí odkaz:
https://doaj.org/article/09be5ee5ee6a4b6e8fc5949394c4bbfc