Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kevin Hakala"'
Autor:
Elizabeth R. Flynn, Courtney Cates, Kevin Hakala, Lisandra E. de Castro Brás, Ying Ann Chiao, Rugmani Padmanabhan Iyer, Susan T. Weintraub
Publikováno v:
PROTEOMICS - Clinical Applications. 10:92-107
Matrix metalloproteinases (MMPs) collectively degrade all extracellular matrix (ECM) proteins. Of the MMPs, MMP-9 has the strongest link to the development of cardiac dysfunction. Aging associates with increased MMP-9 expression in the left ventricle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8a22684951c59c131533bd126605a2
https://doi.org/10.1002/prca.201500038
https://doi.org/10.1002/prca.201500038
Autor:
Ying Ann Chiao, Lisandra E. de Castro Brás, Merry L. Lindsey, Yonggang Ma, Kevin Hakala, Ganesh V. Halade, Kristine Y. DeLeon-Pennell, Qiuxia Dai, Trevi A. Ramirez, Susan T. Weintraub
Publikováno v:
Journal of Proteomics. 86:43-52
The extracellular matrix (ECM) is a critical tissue component, providing structural support as well as important regulatory signaling cues to govern cellular growth, metabolism, and differentiation. The study of ECM proteins, however, is hampered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af548e273eaaad00c0beaa0ec6880b03
https://doi.org/10.1016/j.jprot.2013.05.004
https://doi.org/10.1016/j.jprot.2013.05.004
Publikováno v:
Molecular and Cellular Biology. 32:4388-4399
Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3279bc173a5db1d6bc41ac517cf28f8
https://doi.org/10.1128/mcb.06023-11
https://doi.org/10.1128/mcb.06023-11
Autor:
Marina Goderdzishvili, Susan T. Weintraub, Kevin Hakala, Zemphira Alavidze, Julie A. Thomas, Stephen C. Hardies, Nino Kvatadze, Natia Karumidze
Publikováno v:
Applied Microbiology and Biotechnology. 94:1609-1617
Pseudomonas aeruginosa is an important cause of infections, especially in patients with immunodeficiency or diabetes. Antibiotics are effective in preventing morbidity and mortality from Pseudomonas infection, but because of spreading multidrug-resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1eda82209689a326a99d0a7cc25a6d
https://doi.org/10.1007/s00253-012-4119-8
https://doi.org/10.1007/s00253-012-4119-8
Publikováno v:
Archives of Biochemistry and Biophysics. 518:103-110
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and degrades hypoxia inducible fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf81090ff8165f19d186a9dff76b5c9
https://doi.org/10.1016/j.abb.2011.12.023
https://doi.org/10.1016/j.abb.2011.12.023
Publikováno v:
Journal of Proteome Research. 10:5175-5182
The von Hippel–Lindau (VHL) tumor suppressor gene encodes a component of a ubiquitin ligase complex containing elongin B, elongin C, cullin 2, and Rbx1, which acts as a negative regulator of hypoxia inducible factor (HIF). VHL ubiquitinates and deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014404c7568e6b19154b8c290c71ec74
https://doi.org/10.1021/pr200642c
https://doi.org/10.1021/pr200642c
Publikováno v:
Journal of Proteome Research. 10:5191-5198
Mutation of the BRCA1 tumor suppressor gene predisposes women to hereditary breast and ovarian cancers. BRCA1 forms a heterodimer with BARD1. The BRCA1/BARD1 heterodimer has ubiquitin ligase activity, considered to play crucial roles in tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362b48ed614f287f3bf3265df43ce14a
https://doi.org/10.1021/pr200662b
https://doi.org/10.1021/pr200662b
Publikováno v:
Molecular & Cellular Proteomics. 9:940-951
Pseudomonas chlororaphis phage 201φ2-1 produces a large structurally complex virion, including the products of 89 phage genes. Many of these proteins are modified by proteolysis during virion maturation. To delineate the proteolytic maturation proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e878d0a2f5b74e460f954f350646edb9
https://doi.org/10.1074/mcp.m900488-mcp200
https://doi.org/10.1074/mcp.m900488-mcp200
Autor:
Susan T. Weintraub, Elizabeth F. Lopez, Qiuxia Dai, Ying Ann Chiao, Gladys Patricia Escobar, Kevin Hakala, Merry L. Lindsey, Rogelio Zamilpa
Publikováno v:
Journal of Proteome Research. 9:2649-2657
Matrix metalloproteinase-7 (MMP-7) deletion has been shown to improve survival after myocardial infarction (MI). MMP-7 has a large array of in vitro substrates, but in vivo substrates for MMP-7 following MI have not been fully identified. Accordingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce2603aa2a32943413647c4b81676bf
https://doi.org/10.1021/pr100147r
https://doi.org/10.1021/pr100147r
Publikováno v:
British Journal of Haematology. 142:457-465
Sulfhydryl groups of platelet surface proteins are important in platelet aggregation. While p-chloromercuribenzene sulphonate (pCMBS) has been used in most studies on platelet surface thiols, the specific thiol-proteins that pCMBS reacts with to inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6bbda878b820dff717873a75ec8cf46
https://doi.org/10.1111/j.1365-2141.2008.07200.x
https://doi.org/10.1111/j.1365-2141.2008.07200.x