Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kevin Greenslade"'
Autor:
Timothy Dreyer, Mittal Shah, Carl Doyle, Kevin Greenslade, Mark Penney, Paul Creeke, Apoorva Kotian, Hua Zhu Ke, Vinny Naidoo, Gill Holdsworth
Publikováno v:
Journal of Orthopaedic Translation, Vol 29, Iss , Pp 134-142 (2021)
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current tr
Externí odkaz:
https://doaj.org/article/44e57dc8a4744eafaa88a71c09f93a5a
Autor:
Alison Eddleston, Kevin Greenslade, Kerry Louise Tyson, Bryan Smith, Anthony Shock, Daniel John Lightwood, Louis Christodoulou, Frank R. Brennan, Alison Clargo
Publikováno v:
International Immunopharmacology. 66:362-365
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1314c1a37d96e2bf52a22724dbc515b
https://doi.org/10.1016/j.intimp.2018.11.040
https://doi.org/10.1016/j.intimp.2018.11.040
Autor:
Paul Atherfold, Hanna Hailu, Louis Christodoulou, Lena E. D’Hooghe, Bryan Smith, Helene Margaret Finney, Frank R. Brennan, Stevan Shaw, Kerry Louise Tyson, Daniel John Lightwood, Andrea Kiessling, Kevin Greenslade, Omar Qureshi, Lara Kevorkian, Rebecca Munro, Kate L. Dixon, Rocio Lledo-Garcia, Shauna West, Christoph Meier, Matthew C. Catley, Kaushik Sarkar, Alison Turner, Roohi Tewari, Sophie P. Shaw
Publikováno v:
mAbs
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045641d5108e50151ed33d8046d2ce07
http://europepmc.org/articles/PMC6291300
http://europepmc.org/articles/PMC6291300
Autor:
Kevin Greenslade, H Björkelund, Alison Eddleston, Bryan Smith, Jay Tibbitts, S Crilly, F Junker, Michael D.J. Parkinson, Andrea Kiessling, Robert J. Griffin, Joanne E. Compson, Katharine Cain, Omar Qureshi, Frank R. Brennan, David P. Humphreys, Shirley Jane Peters, Farnaz Fallah-Arani, M Malmqvist, Louis Christodoulou, Nicola L. Davies, L Staelens, E. Ward, Tania F. Rowley, Thomas L. Pither
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e1faf68f03085329d981162044eebb
http://link.springer.com/article/10.1038/s41598-017-17255-8
http://link.springer.com/article/10.1038/s41598-017-17255-8
Autor:
Karin V. Greco, Trinidad Montero-Melendez, Prashant Mori, Kevin Greenslade, Sarah E. Headland, Costantino Pitzalis, Adrian Moore, Magdalena Kaneva, Mauro Perretti
Publikováno v:
The Journal of Immunology. 198:2876-2885
We hypothesized that exudates collected at the beginning of the resolution phase of inflammation might be enriched for tissue protective molecules; thus an integrated cellular and molecular approach was applied to identify novel chondroprotective bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c6ecabf82bd1e6746efea34ca4c157
https://doi.org/10.4049/jimmunol.1601111
https://doi.org/10.4049/jimmunol.1601111
Autor:
Kevin Greenslade, Joby Jose, Zofia Stencel, Hua Zhu Ke, Hishani Kirby, Martyn K. Robinson, Adrian Moore, Gill Holdsworth
Publikováno v:
Bone. 107
Administration of antibodies to sclerostin (Scl-Ab) has been shown to increase bone mass, bone mineral density (BMD) and bone strength by increasing bone formation and decreasing bone resorption in both animal studies and human clinical trials. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabf0212e959b92b0b73a3c811669755
https://pubmed.ncbi.nlm.nih.gov/29129759
https://pubmed.ncbi.nlm.nih.gov/29129759
Autor:
David Ke, Joby Jose, Zofia Stencel, Hishani Kirby, Gill Holdsworth, Adrian Moore, Martyn K. Robinson, Kevin Greenslade
Publikováno v:
Bone Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c644beb63fe86da229d7661245e67a34
https://doi.org/10.1530/boneabs.5.oc2.4
https://doi.org/10.1530/boneabs.5.oc2.4
Autor:
Mark D. Carr, Andrew Ventom, Jianhua Gong, Kevin Greenslade, Vaclav Veverka, Chris Paszty, Li Zhang, Martyn K. Robinson, Richard J. K. Taylor, Mariusz Muzylak, Alistair James Henry, Patrick M. Slocombe, Xueming Qian, Adrian Moore, Barbara Mulloy, Frederick W. Muskett
Publikováno v:
Journal of Biological Chemistry. 284:10890-10900
The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d89f5c62070519d1b7ac2312cf28f01
https://doi.org/10.1074/jbc.m807994200
https://doi.org/10.1074/jbc.m807994200
Autor:
Vaclav, Veverka, Alistair J, Henry, Patrick M, Slocombe, Andrew, Ventom, Barbara, Mulloy, Frederick W, Muskett, Mariusz, Muzylak, Kevin, Greenslade, Adrian, Moore, Li, Zhang, Jianhua, Gong, Xueming, Qian, Chris, Paszty, Richard J, Taylor, Martyn K, Robinson, Mark D, Carr
Publikováno v:
The Journal of biological chemistry. 284(16)
The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46c028547915cd7399181ba5f61e83f3
https://pubmed.ncbi.nlm.nih.gov/19208630
https://pubmed.ncbi.nlm.nih.gov/19208630
Autor:
Roger Palframan, Kevin Greenslade, Helen A. Brand, David Paul Humphreys, Bruce Carrington, Alistair James Henry, Dominc G. Reeks, P. Antoniw, Shauna West, Leigh C Bowering, Layla Ait-Lhadj, Sam Philip Heywood
Publikováno v:
Protein engineering, designselection : PEDS. 20(5)
Antigen-binding fragments (Fab') of antibodies can be site specifically PEGylated at thiols using cysteine reactive PEG-maleimide conjugates. For therapeutic Fab'-PEG, conjugation with 40 kDa of PEG at a single hinge cysteine has been found to confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe882aa2b1b59f77c7f3e482bde8f517
https://pubmed.ncbi.nlm.nih.gov/17452434
https://pubmed.ncbi.nlm.nih.gov/17452434