Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kevin G. Waddick"'
Autor:
Kevin G. Waddick, Fatih M. Uckun
Publikováno v:
Biochemical Pharmacology. 56:1411-1426
Modulation of Ras function may provide a novel means by which cancer cells with oncogenic mutations can be sensitized to chemotherapeutic or radiotherapeutic regimens. Moreover, cancer cells without ras oncogene mutations can also be eliminated by co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fb412aeefa10246c4a56092473ca43
https://doi.org/10.1016/s0006-2952(98)00211-1
https://doi.org/10.1016/s0006-2952(98)00211-1
Publikováno v:
Leukemia & Lymphoma. 25:77-90
We examined the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF), interleukin 3 (rhIL-3) and interleukin 6 (rhIL-6) on the radiation sensitivity of normal and leukemic bone marrow progenitor cell populations. Conditioning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebd9db8b12609345e15a3a28dde969e
https://doi.org/10.3109/10428199709042498
https://doi.org/10.3109/10428199709042498
Autor:
Kevin G. Waddick, Stella M. Davies, Berta Warman, Anne Bendel, Yu Shao, Chang H. Yang, Mridula Chandan-Langlie, Fatih M. Uckun, John P. Perentesis
Publikováno v:
Leukemia & Lymphoma. 25:247-256
Contemporary therapies for acute myeloid leukemia (AML) commonly fail to cure patients because of the emergence of drug resistance. Drug resistance in AML is multifactorial but can be associated with the overexpression of transmembrane transporter mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26261827d8ca78b3bcf833f7209711ec
https://doi.org/10.3109/10428199709114164
https://doi.org/10.3109/10428199709114164
Autor:
Kevin G. Waddick, Tomohiro Kurosaki, Fatih M. Uckun, Joseph B. Bolen, Xiao Jun, Sandeep Mahajan, Minoru Takata
Publikováno v:
Science. 273:1096-1100
Bruton's tyrosine kinase (BTK) is a member of the SRC-related TEC family of protein tyrosine kinases (PTKs). DT-40 lymphoma B cells, rendered BTK-deficient through targeted disruption of the btk gene by homologous recombination knockout, did not unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bf27b9e8e9bd6bf93cf644a24a76cc
https://doi.org/10.1126/science.273.5278.1096
https://doi.org/10.1126/science.273.5278.1096
Autor:
Fatih M. Uckun, R. Bruce Rowley, Dorothea E. Myers, Lisa Tuel-Ahlgren, Kevin G. Waddick, Joseph B. Bolen, Anne L. Burkhardt, Xiao Jun, Jizhong Jin
Publikováno v:
Journal of Biological Chemistry. 271:6389-6397
Exposure of human B-cell precursors (BCP) to ionizing radiation results in cell cycle arrest at the G2-M checkpoint as a result of inhibitory tyrosine phosphorylation of p34cdc2 . Here, we show that ionizing radiation promotes physical interactions b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a3728a57a4a66828a9a3a970f0e9cb
https://doi.org/10.1074/jbc.271.11.6389
https://doi.org/10.1074/jbc.271.11.6389
Autor:
Dorothea E. Myers, Mridula Chandan-Langlie, Kevin G. Waddick, Lisa M. Chelstrom, Nilgun Tumer, Fatih M. Uckun, J. D. Irvin, Roland Gunther
Publikováno v:
Blood. 86:4228-4233
B-cell precursor (BCP) leukemia is the most common form of childhood cancer and represents one of the most radiation-resistant forms of human malignancy. In this study, we examined the antileukemic efficacy of the B43 (anti-CD19)-pokeweed antiviral p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1299e72dad8365d2638150a8e17e8520
https://doi.org/10.1182/blood.v86.11.4228.bloodjournal86114228
https://doi.org/10.1182/blood.v86.11.4228.bloodjournal86114228
Autor:
Mridula Chandan-Langlie, Clinton F. Stewart, Lisa M. Chelstrom, William E. Evans, Kevin G. Waddick, Fatih M. Uckun, Jizhong Jin, G Reaman, James G. White
Publikováno v:
Blood. 85:2817-2828
Topotecan [(S)-9-dimethylaminomethyl-10-hydroxycamptothecin hydrochloride; SK&F 104864-A, NSC 609699], a water soluble semisynthetic analogue of the alkaloid camptothecin, is a potent topoisomerase I inhibitor. Here we show that topotecan stabilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ed259ac2a6e6f445aad98b2a95744a
https://doi.org/10.1182/blood.v85.10.2817.bloodjournal85102817
https://doi.org/10.1182/blood.v85.10.2817.bloodjournal85102817
Autor:
Fatih M. Uckun, Kevin G. Waddick
Publikováno v:
Radiation Oncology Investigations. 1:34-40
The effects of recombinant interleukin-6 (rIL-6) and rIL-3 on the radiation responses of myeloid [colony forming unit-granulocyte-macrophage (CFU-GM)] and erythroid [burst forming unit-erythroid (BFU-E)] human pediatric bone marrow progenitor cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3739d59bfb6e673668eac86e73ddf6
https://doi.org/10.1002/roi.2970010107
https://doi.org/10.1002/roi.2970010107
Autor:
Mridula Chandan-Langlie, Norma K.C. Ramsay, Robert Haake, Waclaw Jaszcz, Kevin G. Waddick, John H. Kersey, Fatih M. Uckun, Chang W. Song, Kazimiera J. Gajl-Peczalska, Vedat Obuz
Publikováno v:
Blood. 78:2945-2955
The radiobiologic features of primary clonogenic blasts (referred to also as T-lineage leukemic progenitor cells) from newly diagnosed and relapsed T-lineage acute lymphoblastic leukemia (ALL) patients were analyzed. Intrinsic radiation sensitivity d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064fd32debfc411c780119a915b161e5
https://doi.org/10.1182/blood.v78.11.2945.2945
https://doi.org/10.1182/blood.v78.11.2945.2945
Autor:
Fatih M. Uckun, Vedat Obuz, Kevin G. Waddick, Chae Heonjoo Park, Lahcen Oubaha, Chang W. Song, Woo Sung Min, Norman Friedman, James Mitchell
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 21:1553-1560
We studied the radiation sensitivity of eight immunophenotypically distinct B-lineage lymphoid precursor cell (LPC) lines of acute lymphoblastic leukemia (ALL) or fetal liver origin corresponding to discrete developmental stages of human B-cell ontog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9e317ec89ecf6d5dcc3d0f3b3fcfcb
https://doi.org/10.1016/0360-3016(91)90332-x
https://doi.org/10.1016/0360-3016(91)90332-x