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of 4
pro vyhledávání: '"Kevin G. Senior"'
Autor:
Geoffrey D. Keeler, Cristina D. Gaddie, Addelynn S. Sagadevan, Kevin G. Senior, Isabelle Côté, Michaela Rechdan, Daniel Min, David Mahan, Bianca Poma, Brad E. Hoffman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 177-189 (2023)
In vivo induction of antigen (Ag)-specific regulatory T cells (Treg) is considered the holy grail of therapeutic strategies for restoring tolerance in autoimmunity. Unfortunately, in the autoimmune disease multiple sclerosis, an effective and durable
Externí odkaz:
https://doaj.org/article/27ce27000c494794b53f69c9f4ea3b9e
Publikováno v:
Microorganisms, Vol 8, Iss 9, p 1432 (2020)
Macrophages are phagocytic cells that play a key role in host immune response and clearance of microbial pathogens. Porphyromonas gingivalis is an oral pathogen associated with the development of periodontitis. Escape from macrophage phagocytosis was
Externí odkaz:
https://doaj.org/article/7986ea3b72b5441792b991762430dbee
Autor:
Kevin G Senior, Isabelle Cote, Addelynn Sonia Sagadevan, Cristina D. Gaddie, Geoffrey D. Keeler, Daniel Min, Madisyn T. Main, Michaela N. Rechdan, Stefanie Assakawa, Brad E. Hoffman
Publikováno v:
The Journal of Immunology. 208:60.17-60.17
Neuromyelitis optica (NMO) is an auto-inflammatory demyelinating disease that typically affects optic nerves and spinal cord that is characterized by the presence of serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). NMO accounts for >45% of t
Autor:
Addelynn Sonia Sagadevan, Geoffrey D. Keeler, Cristina D. Gaddie, Isabelle Cote, Kevin G Senior, Daniel Min, Brad E. Hoffman
Publikováno v:
The Journal of Immunology. 208:60.01-60.01
To re-establish long-term immune tolerance in Multiple Sclerosis (MS), our lab had previously developed a pre-clinical Adeno-associated virus (AAV) gene immunotherapy that is capable of preventing and reversing Myelin Oligodendrocyte Glycoprotein (MO