Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kevin G. Liu"'
Publikováno v:
bioRxiv
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided nucleases that have emerged as powerful tools for genome manipulation and molecular diagnostics. However, these enzymes are prone to cleaving off-target sequences that cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db8ebcd13745ce44bce3e9c73be1aea
https://doi.org/10.1101/2023.05.16.541046
https://doi.org/10.1101/2023.05.16.541046
Autor:
Xuemei Yu, Ji-In Kim, Anthony Barsotti, Milica Momcilovic, Christophe Lamarque, Jeegar Patel, Masha V. Poyurovsky, Jack Gaffney, Koi Morris, Joshua D. Rabinowitz, Kevin G. Liu, David B. Shackelford, Kellen L. Olszewski, Xiao-Jiang Feng
Publikováno v:
Cell chemical biology. 29(3)
Summary Efforts to target glucose metabolism in cancer have been limited by the poor potency and specificity of existing anti-glycolytic agents and a poor understanding of the glucose dependence of cancer subtypes in vivo. Here, we present an extensi
Publikováno v:
J Biopharm Stat
Many Phase I trial designs have been developed to improve upon the standard 3 + 3 design. These designs can be classified as long-memory designs, for example, the continual reassessment method (CRM), and short-memory designs such as the modified toxi
Autor:
Manuel Cajina, Megan Nattini, Michael Sabio, Michael S. Reitman, Dario Doller, Kevin G. Liu, Maria D. Bacolod, Hermogenes N. Jimenez, Sang-Phyo Hong, Michelle A. Uberti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3235-3239
4-(1-Phenyl-1H-pyrazol-4-yl)quinoline (1) was identified by screening the Lundbeck compound collection, and characterized as having mGlu4 receptor positive allosteric modulator properties. Compound 1 is selective over other mGlu receptors and a panel
Autor:
Brian A. Robichaud, Kevin G. Liu
Publikováno v:
Tetrahedron Letters. 52:6935-6938
We report a Ti(OiPr)4/pyridine-mediated Knoevenagel reaction between aromatic ketones and cyanoacetamides to provide Knoevenagel olefin products in good to excellent yields. Almost in all cases studied, a single geometrical isomer was formed and isol
Autor:
Albert J. Robichaud, Cristina Grosanu, Jean Y. Zhang, Lo Jennifer Rebecca, Lee E. Schechter, Thomas A. Comery, Kevin G. Liu, Li Di, Guo Ming Zhang, Yanxuan Cai, Alexander Greenfield, Edward H. Kerns, Deborah L. Smith, James F. Mattes, Dianne Kowal
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:650-662
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylin
Publikováno v:
Tetrahedron. 66:573-577
A general and convenient one-pot synthesis of highly substituted indolines from arylhydrazines and aldehydes is reported. This synthesis allows introduction of substitution at essentially all positions of the indoline nucleus to achieve significant d
Autor:
Kevin G. Liu, Albert J. Robichaud
Publikováno v:
Drug Development Research. 70:145-168
Among the potential therapeutic targets for the development of cognitive enhancers for AD and schizophrenia, the 5-HT6 receptor is of especial interest based on its localization, pharmacology, and recent behavioral data showing that 5-HT6 receptor bl
Autor:
Daniel D. Sternbach, Timothy M. Willson, Peter Brown, Kevin G. Liu, William R. Oliver, Kelli D. Plunket, Ludwig William Stuart, Millard H. Lambert, Ronda J. Ott, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2959-2962
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demons
Autor:
Andrea H. Ayscue, Daniel D. Sternbach, Millard H. Lambert, Jennifer S. Smith, Timothy M. Willson, Brad R. Henke, Kelli D. Plunket, Kevin G. Liu, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2385-2388
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPA