Výsledky vyhledávání - "Kevin G. Leidal"

A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN)

Autor: Nienke W.M. de Jong, Benjamin B. Katz, Kevin G. Leidal, William M. Nauseef, Om Prakash, Brandon L. Garcia, Brian V. Geisbrecht, Jos A. G. van Strijp, Nicoleta Ploscariu, Kasra X. Ramyar, Kok P. M. van Kessel, Alvaro I. Herrera

Publikováno v: Journal of Biological Chemistry, 293(7), 2260. American Society for Biochemistry and Molecular Biology Inc.

The heme-containing enzyme myeloperoxidase (MPO) is critical for optimal antimicrobial activity of human neutrophils. We recently discovered that the bacterium Staphylococcus aureus expresses a novel immune evasion protein, called SPIN, that binds ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ce1d6b2d27ede33a9b7200021ee402
https://dspace.library.uu.nl/handle/1874/363887

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Neutrophil Bleaching of GFP-Expressing Staphylococci: Probing the Intraphagosomal Fate of Individual Bacteria

Autor: Jamie Schwartz, Jerrold Weiss, Jon Femling, Kevin G. Leidal, William M. Nauseef

Publikováno v: The Journal of Immunology. 183:2632-2641

Successful host defense against bacteria such as Staphylococcus aureus (SA) depends on a prompt response by circulating polymorphonuclear leukocytes (PMN). Stimulated PMN create in their phagosomes an environment inhospitable to most ingested bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc10b590d3ffb3dc35b593fd6dcf02c9
https://doi.org/10.4049/jimmunol.0804110

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Regulation of Calreticulin Expression during Induction of Differentiation in Human Myeloid Cells

Autor: Robert A. Clark, Senlin Li, Kevin G. Leidal, Robert L. Reddick, Doran W. Pearson, Gerene M. Denning, Joshua R. Clark, Karl-Heinz Krause, Anthony J. Valente

Publikováno v: Journal of Biological Chemistry. 277:32369-32378

Induction of differentiation of HL-60 human myeloid cells profoundly affected expression of calreticulin, a Ca(2+)-binding endoplasmic reticulum chaperone. Induction with Me(2)SO or retinoic acid reduced levels of calreticulin protein by approximatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::222d8e03093da5a86540a2dc36c5c218
https://doi.org/10.1074/jbc.m205269200

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Contribution of liver alcohol dehydrogenase to metabolism of alcohols in rats

Autor: David W. Green, Bruce P. Murch, Bryce V. Plapp, Kevin G. Leidal

Publikováno v: Chemico-biological interactions. 234

The kinetics of oxidation of various alcohols by purified rat liver alcohol dehydrogenase (ADH) were compared with the kinetics of elimination of the alcohols in rats in order to investigate the roles of ADH and other factors that contribute to the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bbcd6ed5273c44914514d2d69c1cba
https://pubmed.ncbi.nlm.nih.gov/25641189

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Calreticulin Biosynthesis and Processing in Human Myeloid Cells: Demonstration of Signal Peptide Cleavage and N-Glycosylation

Autor: Robert A. Clark, Shankar S. Iyer, Gerene M. Denning, Joshua R. Clark, Doran W. Pearson, Valerie A. Holst, Kevin G. Leidal, William M. Nauseef

Publikováno v: Blood. 90:372-381

Calreticulin is a soluble endoplasmic reticulum protein comprising the major storage reservoir for inositol trisphosphate-releasable calcium. Although its highly conserved primary structure and a wide range of functions have been well described, less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04f6034177bf4d1905e263fec6d1fe15
https://doi.org/10.1182/blood.v90.1.372

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Functional Consequence of Positive Selection Revealed through Rational Mutagenesis of Human Myeloperoxidase

Autor: Sinéad T. Loughran, Kevin G. Leidal, Mary J. O'Connell, Sally McCormick-Hill, Noeleen B. Loughran, William M. Nauseef, Ciarán Ó'Fágáin, Sara Hinde, Sarah Bloomberg, Brendan O'Connor

Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604bc5d8bd847a0c55c8ba43dca4db8c
https://europepmc.org/articles/PMC3408071/

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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Autor: Yvonne Westermaier, Leonardo Scapozza, William M. Nauseef, Julien Marcoux, Karl-Heinz Krause, Sally McCormick, Karen Bedard, Remo Perozzo, Becky A. Diebold, Kevin G. Leidal, Vincent Jaquet, Laetitia Fioraso-Cartier, Olivier Plastre, Eric Forest, Franck Fieschi

Publikováno v: British Journal of Pharmacology, Vol. 164, No 2b (2011) pp. 507-20
British Journal of Pharmacology
British Journal of Pharmacology, Wiley, 2011, 164 (2b), pp.507-520. ⟨10.1111/j.1476-5381.2011.01439.x⟩
British Journal of Pharmacology, 2011, 164 (2b), pp.507-520. ⟨10.1111/j.1476-5381.2011.01439.x⟩

International audience; BACKGROUND Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e10874075658d656a4bfec648fe107
https://pubmed.ncbi.nlm.nih.gov/21501142

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Functional domain in an arginine-rich carboxyl-terminal region of p47phox

Autor: William M. Nauseef, Jan Renee, Sally McCormick, Kevin G. Leidal, Robert A. Clark

Publikováno v: Journal of Biological Chemistry. 268:23646-23651

Activation of the neutrophil respiratory burst oxidase involves phosphorylation-dependent translocation of the cytosolic proteins p47phox and p67phox to the plasma membrane, a process in intact cells that is inhibited by staurosporine. We now report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfc70aaf26fd48343478d41db1fce113
https://doi.org/10.1016/s0021-9258(19)49511-2

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Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components

Autor: Bryan D. Volpp, Robert A. Clark, Kevin G. Leidal, William M. Nauseef, Sally McCormick

Publikováno v: Journal of Biological Chemistry. 266:5911-5917

Activated human polymorphonuclear neutrophils (PMNs) convert molecular oxygen into superoxide anion, a process known as the respiratory burst, through the activity of a latent multicomponent NADPH-dependent oxidase. Components of this respiratory bur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d7d81768343404ef43dc1c7712b5da
https://doi.org/10.1016/s0021-9258(19)67684-2

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Autor: Thomas S. Griffith, Kevin G. Leidal, Mark P. Simons, William M. Nauseef

Publikováno v: Journal of leukocyte biology. 83(3)

TRAIL induces apoptosis in a variety of tumor cells. Our laboratory found that human neutrophils contain an intracellular reservoir of prefabricated TRAIL that is released after stimulation with Mycobacterium bovis bacillus Calmette-Guérin. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf26efe0329b440f68a5bb9776eb689
https://pubmed.ncbi.nlm.nih.gov/18063697

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