Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kevin G. Lambe"'
Publikováno v:
Biochemical and Biophysical Research Communications. 239:522-526
We have investigated the basis of the lack of activity of a natural variant human peroxisome proliferator-activated receptor alpha, hPPARalpha6/29. A subcloning approach was used to change the four variant amino acids in the hPPARalpha6/29 sequence,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8dc63e7fad134fe03f924e3713e457
https://doi.org/10.1006/bbrc.1997.7507
https://doi.org/10.1006/bbrc.1997.7507
Autor:
Douglas A. West, Peter R. Holden, Ruth A. Roberts, N.J Woodyatt, Neil Macdonald, Neil H. James, Susan C. Hasmall, D Whitcome, Kevin G. Lambe
Publikováno v:
Toxicology letters.
Peroxisome proliferators (PPs) are nongenotoxic rodent hepatocarcinogens that cause liver enlargement and hepatocarcinogenesis associated with peroxisome proliferation, induction of hepatocyte DNA synthesis and suppression of apoptosis. Acyl CoA oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad479f82a91d50cb343e764dce18e02
https://pubmed.ncbi.nlm.nih.gov/10720712
https://pubmed.ncbi.nlm.nih.gov/10720712
Publikováno v:
Carcinogenesis. 20(3)
Peroxisome proliferators (PP) cause peroxisome proliferation, associated with rodent hepatocyte growth perturbation and hepatocarcinogenesis. However, in humans this class of non-genotoxic carcinogens does not appear to have the same adverse effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa8e52624c01fd4f67015400b384e73
https://pubmed.ncbi.nlm.nih.gov/10190548
https://pubmed.ncbi.nlm.nih.gov/10190548
Publikováno v:
Archives of Toxicology ISBN: 9783642468582
Peroxisome proliferators (PPs) form a discrete class of rodent non-genotoxic hepatocarcinogens (see Stringer, 1992 for review). These chemicals, which include industrially and pharmaceutically important compounds such as chlorinated solvents, plastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::227dcadf801711200c6507953e7f7581
https://doi.org/10.1007/978-3-642-46856-8_33
https://doi.org/10.1007/978-3-642-46856-8_33
Publikováno v:
Annals of the New York Academy of Sciences. 804
We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b418d7a5fbd5c2924f1943bceac6eda
https://pubmed.ncbi.nlm.nih.gov/8993548
https://pubmed.ncbi.nlm.nih.gov/8993548
Autor:
Jonathan D. Tugwood, Kevin G. Lambe
Publikováno v:
European journal of biochemistry. 239(1)
We have cloned a human cognate of the mouse peroxisome-proliferator-activated receptor-gamma (hPPAR gamma) from a human placenta cDNA library. Sequence analysis reveals a high degree of similarity with the mouse receptor and, like other PPAR, hPPAR g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f454d40497899bb6486ebcb6a13e66
https://pubmed.ncbi.nlm.nih.gov/8706692
https://pubmed.ncbi.nlm.nih.gov/8706692
Publikováno v:
Europe PubMed Central
In rats and mice, peroxisome proliferators (PP) cause liver enlargement, hepatocarcinogenesis and peroxisome proliferation associated with induction of enzymes such as acyl CoA oxidase (ACO). However, humans appear to be non-responsive to the adverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdfe36a944a63b3d800d5caaf1581b5
http://europepmc.org/abstract/med/10593603
http://europepmc.org/abstract/med/10593603