Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kevin G, Moffat"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Tau is a predominantly neuronal protein that is normally bound to microtubules, where it acts to modulate neuronal and axonal stability. In humans, pathological forms of tau are implicated in a range of diseases that are collectively known as tauopat
Externí odkaz:
https://doaj.org/article/00a550f6d9b9496bb6994a87d8e6064b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Mutations in the MAPT gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly understood. Here, we characterized the aggregation stages and conformational changes of tau C2
Externí odkaz:
https://doaj.org/article/fe20e8ac53ec4ff29150e29f590d1df4
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1434-1444 (2017)
Neurodegenerative tauopathies are characterised by accumulation of hyperphosphorylated tau aggregates primarily degraded by autophagy. The 5′AMP-activated protein kinase (AMPK) is expressed in most cells, including neurons. Alongside its metabolic
Externí odkaz:
https://doaj.org/article/9d610f3feed54b8c9856733997a1183d
Autor:
Thomas K. Karikari, David A. Nagel, Alastair Grainger, Charlotte Clarke-Bland, James Crowe, Eric J. Hill, Kevin G. Moffat
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The inter-cellular propagation of tau aggregates in several neurodegenerative diseases involves, in part, recurring cycles of extracellular tau uptake, initiation of endogenous tau aggregation, and extracellular release of at least part of this prote
Externí odkaz:
https://doaj.org/article/13e6659807bd4a86a1a81109953159b6
Autor:
Emily Hill, Kevin G. Moffat, Mark J. Wall, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f11dd948609c8d26adc531a164de80
https://doi.org/10.1007/978-1-0716-2597-2_14
https://doi.org/10.1007/978-1-0716-2597-2_14
Autor:
Emily, Hill, Kevin G, Moffat, Mark J, Wall, Henrik, Zetterberg, Kaj, Blennow, Thomas K, Karikari
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Aggregated tau protein plays a key role in the pathogenesis of neurodegenerative tauopathies including Alzheimer's disease. Soluble, low-molecular-weight tau oligomers are formed early in disease processes and are thought to have toxic functions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27110bec8a46f74238262fcb69e96950
https://pubmed.ncbi.nlm.nih.gov/36310202
https://pubmed.ncbi.nlm.nih.gov/36310202
Autor:
Emily, Hill, Kevin G, Moffat, Mark J, Wall, Henrik, Zetterberg, Kaj, Blennow, Thomas K, Karikari
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
There is growing evidence that tau oligomers are a major pathological species in a number of tauopathies including Alzheimer's disease. However, it is still unclear what exact mechanisms underlie tau oligomer-mediated dysfunction. Studies of tau olig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd0d3692a07806a424ab54034692af5c
https://pubmed.ncbi.nlm.nih.gov/36310205
https://pubmed.ncbi.nlm.nih.gov/36310205
Autor:
Zunoon Hussain, Ashish Jain, Kevin G. Moffat, Terje Johansen, Anne-Claire Jacomin, Mark Eddison, Tamas Maruzs, Andreas Jenny, Margaux Sica, Ioannis P. Nezis, Ágnes Varga, Raksha Gohel, Gábor Juhász
Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e90c80dfd4b9b372750edeb57419dab
http://wrap.warwick.ac.uk/144917/7/WRAP-Degradation-arouser-endosomal-microautophagy-starvation-Drosophila-Nezis-2020.pdf
http://wrap.warwick.ac.uk/144917/7/WRAP-Degradation-arouser-endosomal-microautophagy-starvation-Drosophila-Nezis-2020.pdf
Autor:
Juan Rodríguez-Lantero, Kevin G. Moffat, Emily Hill, Kaj Blennow, Thomas K. Karikari, Maria Olsson, Henrik Zetterberg
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78be65b8d2f43a10c91f0bad1e698478
https://doi.org/10.1002/alz.045387
https://doi.org/10.1002/alz.045387
Autor:
Anne-Claire, Jacomin, Raksha, Gohel, Zunoon, Hussain, Agnes, Varga, Tamas, Maruzs, Mark, Eddison, Margaux, Sica, Ashish, Jain, Kevin G, Moffat, Terje, Johansen, Andreas, Jenny, Gabor, Juhasz, Ioannis P, Nezis
Publikováno v:
Life Science Alliance
Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival.
Hunger drives food-seeking behaviour and controls adaptation of
Hunger drives food-seeking behaviour and controls adaptation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::234a5605aaffaa0ac7fca1e5b8230641
https://pubmed.ncbi.nlm.nih.gov/33318080
https://pubmed.ncbi.nlm.nih.gov/33318080