Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kevin Flurkey"'
Autor:
Peter C. Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A. Calcutt, Robert A. Koza, David E. Harrison
Publikováno v:
Aging cell, vol 21, iss 9
Rapamycin treatment has positive and negative effects on progression of type 2 diabetes (T2D) in a recombinant inbred polygenic mouse model, male NONcNZO10/LtJ (NcZ10). Here, we show that combination treatment with metformin ameliorates negative effe
Autor:
David E. Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, Marisa Lopez‐Cruzan, Francesca Macchiarini, James F. Nelson, Adrian Markewych, Alessandro Bitto, Amy L. Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M. Stearns, Molly Bogue, Richard A. Miller
Publikováno v:
Aging Cell
Aging cell, vol 20, iss 5
Aging cell, vol 20, iss 5
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p
Interventions that increase lifespan when started late in life ar
Interventions that increase lifespan when started late in life ar
Autor:
Kevin Flurkey, Ian Mills, Peter C. Reifsnyder, Sergey Ryzhov, David E. Harrison, Rea P. Anunciado-Koza, Robert A. Koza
Publikováno v:
Annals of the New York Academy of Sciences. 1418:106-117
Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardio
Autor:
Tim Stearns, Randy Strong, Elizabeth Fernandez, Richard A. Miller, Joel Brind, James F. Nelson, Alexey G. Ryazanov, Martin A. Javors, Warren Ladiges, Kevin Flurkey, Molly A. Bogue, Douglas E. Vaughan, Jessica M. Snyder, C. Michael Astle, David E. Harrison, Christiaan Leeuwenburgh, Francesca Macchiarini
Publikováno v:
Aging Cell
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore e
Autor:
Elizabeth Fernandez, Adam B. Salmon, Martin A. Javors, Molly A. Bogue, Paul Anthony Martinez, Martin S. Denzel, David M. Sabatini, David E. Harrison, Karyn L. Hamilton, João Pedro de Magalhães, Dudley W. Lamming, James F. Nelson, Joe M. McCord, Richard A. Miller, Arlan Richardson, Randy Strong, Juliet Ndukum, Benjamin F. Miller, G. Ed Rainger, Wilma T. Steegenga, James W. Simpkins, Clinton M. Astle, Michael Müller, Nancy L. Nadon, Kevin Flurkey, Adam Antebi
Publikováno v:
Aging Cell
AGING CELL
Aging Cell, 15(5), 872-884
Wiley
Aging Cell 15 (2016) 5
AGING CELL
Aging Cell, 15(5), 872-884
Wiley
Aging Cell 15 (2016) 5
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each compound is tested in parallel at three sites, and all results are published. We re
Autor:
Richard A. Miller, Kevin Flurkey, Moshe Levi, James F. Nelson, Francesca Macchiarini, Gordon J. Lithgow, Tim Stearns, Jonathan Gelfond, Martin A. Javors, John DiGiovanni, Silvestre Alavez, Thomas J. Slaga, Michael Garratt, John E. Wilkinson, Elizabeth Fernandez, David E. Harrison, Randy Strong, Stacey J. Sukoff Rizzo, Clinton M. Astle
Publikováno v:
Aging Cell
To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at
Autor:
Peter C, Reifsnyder, Sergey, Ryzhov, Kevin, Flurkey, Rea P, Anunciado-Koza, Ian, Mills, David E, Harrison, Robert A, Koza
Publikováno v:
Annals of the New York Academy of Sciences. 1418(1)
Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardio
Autor:
Scott D. Pletcher, David E. Harrison, Randy Strong, James W. Simpkins, J. Erby Wilkinson, Clinton M. Astle, Martin A. Javors, David B. Allison, Elizabeth Fernandez, Hani Atamna, Bruce N. Ames, Kevin Flurkey, James F. Nelson, Richard A. Miller, Nancy L. Nadon, Daniel L. Smith
Publikováno v:
Aging Cell
Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB) — were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan
Publikováno v:
Aging (Albany NY)
Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment prod
Publikováno v:
The Journals of Gerontology: Series A. 68:27-35
Aging and healthy life span are complex traits affected by many genes in multiple biological and molecular pathways. In normal populations, adaption to a variety of environments resulted in genetic polymorphisms that regulate pathways—such as insul