Výsledky vyhledávání - "Kevin Flannagan"

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

Autor: Diane M. Simeone, Ashley Velez-Delgado, Gregory L. Beatty, Esha Mathew, Dongjun Li, Kevin Flannagan, Yaqing Zhang, Andrew D. Rhim, Marina Pasca di Magliano, Flor M. Mendez

Publikováno v: Gut

Background Pancreatic cancer is characterised by the accumulation of a fibro-inflammatory stroma. Within this stromal reaction, myeloid cells are a predominant population. Distinct myeloid subsets have been correlated with tumour promotion and unmask

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6b2d40e7916902706d7ab4d6670c01
https://doi.org/10.1136/gutjnl-2016-312078

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Abstract 2963: Inhibition of stromal p38MAPK abrogates breast cancer metastasis

Autor: Kathleen Weilbaecher, Sheila A. Stewart, Roberta Faccio, Yujie Fu, Bhavna Murali, Joseph B. Monahan, Kathlees Leahy, Jasmine Sponagel, Kevin Flannagan, Qiaho Ren, Xianmin Luo, Elise Alspach, Xinming Su

Publikováno v: Cancer Research. 77:2963-2963

Bone metastasis is a devastating and fatal complication of breast cancer for which we lack effective therapies. Thus, identifying therapies that effectively limit metastases will significantly reduce comorbidities and improve long-term survival. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82fc8ea75b69480db6e6aaab53195b86
https://doi.org/10.1158/1538-7445.am2017-2963

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Abstract IA21: Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immune-suppressive environment in pancreatic cancer

Autor: Kristen B. Long, Ashley Velez-Delgado, Gregory L. Beatty, Kevin Flannagan, Marina Pasca di Magliano, Flor M. Mendez, Esha Mathew, Andrew D. Rhim, Yaqing Zhang, Dongjun Li, Diane M. Simeone

Publikováno v: Cancer Research. 76:IA21-IA21

Pancreatic cancer is characterized by the accumulation of a fibro-inflammatory stroma. Accumulation of the stroma is already evident surrounding Pancreatic Intraepithelial Neoplasias (PanINs), common precursor lesions to pancreatic cancer (Hezel et a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a4b8857e0483938b8494a4bef0453af
https://doi.org/10.1158/1538-7445.panca16-ia21

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Abstract LB-205: Myeloid cells are required to establish an immune-suppressive regulatory network in pancreatic cancer by activating the PD-1/PD-L1 checkpoint

Autor: Marina Pasca di Magliano, Diane M. Simeone, Esha Mathew, Flor M. Mendez, Kevin Flannagan, Yaqing Zhang

Publikováno v: Cancer Research. 75:LB-205

Background: Pancreatic cancer is characterized by the accumulation of a fibro-inflammatory stroma. Myeloid cells are a predominant population within the stroma. Different myeloid cell subsets have been correlated with tumor promotion and unmasking of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8be9cf9f87ba6f090576f6a030dd3a8
https://doi.org/10.1158/1538-7445.am2015-lb-205

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