Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kevin Ferreri"'
Autor:
Asami Okada, Misuzu Yamada‐Yamashita, Yukari Tominaga, Kyoka Jo, Hiroyasu Mori, Reiko Suzuki, Masashi Ishizu, Motoyuki Tamaki, Yuko Akehi, Yuichi Takashi, Daisuke Koga, Eisuke Shimokita, Fuminori Tanihara, Kiyoe Kurahashi, Sumiko Yoshida, Yukari Mitsui, Shiho Masuda, Itsuro Endo, Ken‐ichi Aihara, Shoji Kagami, Masahiro Abe, Kevin Ferreri, Yoshio Fujitani, Munehide Matsuhisa, Akio Kuroda
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 7, Pp 1140-1148 (2022)
Abstract Aims/Introduction Several research groups have reported methods for quantifying pancreatic beta cell (β‐cell) injury by measuring β‐cell‐specific CpG unmethylation of the insulin gene in circulation using digital droplet PCR or next
Externí odkaz:
https://doaj.org/article/885cf638d27f4b7d8643cfc191e2e4cf
Autor:
Jacques C. Mbongue, Ali Alhoshani, Jeffrey Rawson, Pablo A. Garcia, Nelson Gonzalez, Kevin Ferreri, Fouad Kandeel, Mohamed I. Husseiny
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Type 1 diabetes (T1D) arises secondary to immune-driven destruction of pancreatic β-cells and manifests as insulin-deficient hyperglycemia. We showed that oral vaccination with live attenuated Salmonella, which simultaneously delivers autoantigens a
Externí odkaz:
https://doaj.org/article/4415d35167b14275bf9e4df46af04ba2
Autor:
Mohamed I. Husseiny, Ahmed Fahmy, Weiting Du, Angel Gu, Pablo Garcia, Kevin Ferreri, Fouad Kandeel
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Regulatory T cells (Tregs) suppress immune responses in vivo in an antigen-specific manner. Of clinical relevance, Tregs can be isolated and expanded in vitro while maintaining immunoregulatory function. Tregs are classified as CD4+CD25highCD127low F
Externí odkaz:
https://doaj.org/article/2cfa05842cf647208d2911025bf64fa6
Autor:
Jacques C. Mbongue, Jeffrey Rawson, Pablo A. Garcia, Nelson Gonzalez, Jacob Cobb, Fouad Kandeel, Kevin Ferreri, Mohamed I. Husseiny
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We ar
Externí odkaz:
https://doaj.org/article/15614e04a26a48d782330488da2c5f58
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221456 (2019)
Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice. In humans, administration of a bolus of gastrin alone
Externí odkaz:
https://doaj.org/article/10def19254c942c0a16090f99949c62a
Autor:
Sunil M Kurian, Kevin Ferreri, Chia-Hao Wang, Ivan Todorov, Ismail H Al-Abdullah, Jeffrey Rawson, Yoko Mullen, Daniel R Salomon, Fouad Kandeel
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185331 (2017)
There is growing evidence that transplantation of cadaveric human islets is an effective therapy for type 1 diabetes. However, gauging the suitability of islet samples for clinical use remains a challenge. We hypothesized that islet quality is reflec
Externí odkaz:
https://doaj.org/article/660e691b568143b8911242dbfc74c4d5
Autor:
Meirigeng Qi, Brian McFadden, Luis Valiente, Keiko Omori, Shiela Bilbao, Jemily Juan, Jeffrey Rawson, Alina R. Oancea, Stephen Scott, Indu Nair, Kevin Ferreri, Yoko Mullen, Donald Dafoe, Mohamed Ei-Shahawy, Fouad Kandeel, Ismail H. Al-Abdullah
Publikováno v:
Cell Transplantation, Vol 24 (2015)
The aim of this study was to investigate the effects of elevated donor HbA1c levels (type 2 diabetes, T2D) on the islet yield and functionality postisolation. In this retrospective analysis, donors for islet isolations were classified into two groups
Externí odkaz:
https://doaj.org/article/9817f55662c94171a75b2e54c771148f
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94591 (2014)
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of the majority of pancreatic insulin-producing beta cells. We previously demonstrated that the DNA encoding the insulin gene is uniquely unmethylated i
Externí odkaz:
https://doaj.org/article/750a435b69a5451d92195f79adbbaa67
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47942 (2012)
DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often exhibit unique patterns of DNA methylation. We previously reported that the mouse insulin-2 gene (Ins2) promoter has three potential methylation (CpG
Externí odkaz:
https://doaj.org/article/58761fb77e214c52b960949effcb7093
Autor:
Akio Kuroda, Tibor A Rauch, Ivan Todorov, Hsun Teresa Ku, Ismail H Al-Abdullah, Fouad Kandeel, Yoko Mullen, Gerd P Pfeifer, Kevin Ferreri
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6953 (2009)
BACKGROUND:Insulin is a critical component of metabolic control, and as such, insulin gene expression has been the focus of extensive study. DNA sequences that regulate transcription of the insulin gene and the majority of regulatory factors have alr
Externí odkaz:
https://doaj.org/article/b496c872667149d29c00a5ddb8e448e7