Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevin F. McGee"'
Autor:
Marieke Lamers, Jiffry Ismail, Kevin F. McGee, John Wityak, Gwen Wang, Jonathan Bard, Leticia Toledo-Sherman, Michele Luche, Mei Bai, Michael Conlon, W. Brent Clayton, Michael A. Lynch, Celia Dominguez, James C. Haber, Dawn Yates, Ryan Newell, Pat Wheelan, Ren Hua Song, Susan Deupree, Tania Mead, Macarena Irigoyen, Ignacio Munoz-Sanjuan, Douglas B. Kitchen, Emily Freeman, Kim L. Matthews, Jeff Webster, Bryan Cordell Duffy, IokTeng D. Kuok, Peter C. Michels, Alex S. Kiselyov, Steve Clifton, Lynette Ongeri, David D. Manning, Maria Beconi, Kathy Lyons, Yuri L. Khmelnitsky, Philip Leonard, Claire Wilson, Monica Hultman
Publikováno v:
Journal of Medicinal Chemistry. 58:2967-2987
Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc502c0699e7153c7e8c0b037ee2fc1
https://doi.org/10.1021/jm5013598
https://doi.org/10.1021/jm5013598
Publikováno v:
Synthesis. 112:1185-1196
Intramolecular photocycloaddition of a three-carbon tethered pyrindinone–pyridone system yields the 5-8-5 ring system of the fusicoccin/ophiobolin/ceroplastol families. The stereoselectivity of the cycloaddition was found to be dependent on nitroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30acbbcbb74e933cdd036ae43492094f
https://doi.org/10.1055/s-2001-15066
https://doi.org/10.1055/s-2001-15066
Publikováno v:
The Journal of Organic Chemistry. 65:6676-6681
Intramolecular photocycloaddition of 2-pyridones connected through a four-carbon tether (6-[4-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-4-[[(1,1-dimethylethyl)++ +dimethylsilyl]oxy]butyl]-4-methoxy-1,3-dimethyl-2(1H)-pyridinone) yields a single tetrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816dcab2c14567faf3d3460207fba8da
https://doi.org/10.1021/jo005532c
https://doi.org/10.1021/jo005532c
Publikováno v:
The Journal of Organic Chemistry. 65:1972-1977
Pyridones, well-known for their ability to photodimerize, have been found to undergo [4 + 4] photocycloaddition with furan and naphthalene but not with benzene. In some cases these reactions can be highly regio- and stereospecific. Intramolecular rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d12f00d1912adf1e55dd630c60af875
https://doi.org/10.1021/jo9918394
https://doi.org/10.1021/jo9918394
Publikováno v:
Tetrahedron Letters. 40:4007-4010
A synthetic approach to fusicoccin A utilizing intramolecular photocycloaddition of tethered 2-pyridones has been completed. This study has led to the first solvent-dependent 2-pyridone photo-cycloaddition yielding either cis or trans products. Epoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f549f2f040f20d9986df3c3706060710
https://doi.org/10.1016/s0040-4039(99)00671-1
https://doi.org/10.1016/s0040-4039(99)00671-1
Autor:
Michael P. Trova, Kevin F. McGee
Publikováno v:
Tetrahedron. 51:5951-5954
An efficient synthesis of amino acid ester 8 is described featuring an asymmetric aza-Diels-Alder reaction of diene 5 and chiral imine 6 which establishes the asymmetry at C-3. Hydrogenation of 7 provides 8 with the desired asymmetry at C-4a and C-8a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7606534cc81f196ebbb96a95f201049
https://doi.org/10.1016/0040-4020(95)00266-b
https://doi.org/10.1016/0040-4020(95)00266-b
Autor:
David B. Reitz, Xiangyang Chen, James Robert Blinn, Horng-Chih Huang, Kevin F. McGee, Shengtian Yang, Marvin J. Meyers, Jessica D. Dietz, Danny J. Garland, Joseph R. Rico, Graciela B. Arhancet, Joe T. Collins, Maria A. Payne, Matthew W. Mahoney, Susan L. Hockerman, Marcia I. Heron, Xiao Hu, Bruce L. Homer, Scott A. Long, Jay M. Wendling
Publikováno v:
Journal of medicinal chemistry. 53(16)
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogues were poorly soluble and had a propensity to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f050d0c3dc870966f983df9d6dea1c
https://pubmed.ncbi.nlm.nih.gov/20672822
https://pubmed.ncbi.nlm.nih.gov/20672822
Autor:
Scott McN. Sieburth, Kevin F. McGee
Publikováno v:
Organic Letters. 1:1775-1777
[formula: see text] A solvent-dependent stereoselectivity found for intramolecular [4 + 4] photocycloaddition of tethered 2-pyridones is concentration dependent, indicating that a dimeric structure with four hydrogen bonds plays a critical role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5123491143a5dc8ca7faa85fd2785e68
https://doi.org/10.1021/ol991058p
https://doi.org/10.1021/ol991058p
Publikováno v:
ChemInform. 34
A bicyclo[3.1.0]hexane, with one cyclopropane carbon flanked by a ketone and an ester or an aldehyde, undergoes methanolysis with cleavage of one of the two activated cyclopropane bonds, depending on the reaction conditions. Acidic conditions yield p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4142ede8544be3f7b363b85127888871
https://doi.org/10.1002/chin.200306039
https://doi.org/10.1002/chin.200306039
Autor:
John Wityak, Kevin F. McGee, MichaelP. Conlon, Ren Hua Song, Bryan C. Duffy, Brent Clayton, Michael Lynch, Gwen Wang, Emily Freeman, James Haber, Douglas B. Kitchen, David D. Manning, Jiffry Ismail, Yuri Khmelnitsky, Peter Michels, Jeff Webster, Macarena Irigoyen, Michele Luche, Monica Hultman, Mei Bai
Publikováno v:
Journal of Medicinal Chemistry; Apr2015, Vol. 58 Issue 7, p2967-2987, 21p