Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kevin F Bieniek"'
Publikováno v:
Free Neuropathology, Vol 1 (2020)
Background: The majority of cases of frontotemporal lobar degeneration (FTLD) are characterized by focal cortical atrophy with an underlying tau or TDP-43 proteinopathy. A subset of FTLD cases, however, lack tau and TDP-43 immunoreactivity, but have
Externí odkaz:
https://doaj.org/article/b1053bf272a349769d3e5604473f566c
Autor:
Morgan Mekale Smith, Elizabeth Ochoa, Savannah Barannikov, Mallory Keating, Mohamad Habes, Margaret E. Flanagan, Sudha Seshadri, Kevin F. Bieniek
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103246- (2024)
Summary: Despite numerous neuropathological criteria for the evaluation of microscopic tissue slides, there are no systemic standards for sectioning postmortem human brain tissue. Here, we present a protocol for postmortem brain hybrid structured-lig
Externí odkaz:
https://doaj.org/article/80e35c9343934e4f8894c4661110771e
Autor:
Jonathan D. Cherry, Zach H. Baucom, Kaleb G. Eppich, Daniel Kirsch, Erin R. Dixon, Yorghos Tripodis, Kevin F. Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F. Crary, Dennis Dickson, Ann C. McKee
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The most common tauopathy is Alzheimer’s disease (AD), but chronic traumatic encephalopathy
Externí odkaz:
https://doaj.org/article/be5952978cc942619b569808f18dfc72
Autor:
Sijia He, Shulan Qiu, Meixia Pan, Juan P. Palavicini, Hu Wang, Xin Li, Anindita Bhattacharjee, Savannah Barannikov, Kevin F. Bieniek, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 7, Pp n/a-n/a (2023)
Abstract Background Despite being a brain disorder, Alzheimer's disease (AD) is often accompanied by peripheral organ dysregulations (e.g., loss of bladder control in late‐stage AD), which highly rely on spinal cord coordination. However, the causa
Externí odkaz:
https://doaj.org/article/0d768f66a1884131945072162b73e1a2
Autor:
Adrian Beckmann, Paulino Ramirez, Maria Gamez, Elias Gonzalez, Jasmine De Mange, Kevin F. Bieniek, William J. Ray, Bess Frost
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106152- (2023)
Summary: In Alzheimer’s disease, neurons acquire phenotypes that are also present in various cancers, including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-mitotic neurons is sufficient to induce cell death.
Externí odkaz:
https://doaj.org/article/5965e057071d4ba79c8f4735a9a83cf8
Autor:
Nobutaka Sakae, Shanu F. Roemer, Kevin F. Bieniek, Melissa E. Murray, Matthew C. Baker, Koji Kasanuki, Neill R. Graff‐Radford, Leonard Petrucelli, Marka Van Blitterswijk, Rosa Rademakers, Dennis W. Dickson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1782-1796 (2019)
Abstract Objective To identify clinicopathological differences between frontotemporal lobar degeneration (FTLD) due to mutations in progranulin (FTLD‐GRN) and chromosome 9 open reading frame 72 (FTLD‐C9ORF72). Methods We performed quantitative ne
Externí odkaz:
https://doaj.org/article/7f413b148bef45bca5c50915fd71e1b1
Autor:
Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Jean-Paul Vonsattel, Andy F Teich, Marla Gearing, Jonathan Glass, Juan C Troncoso, Matthew P Frosch, Bradley T Hyman, Melissa E Murray, Johannes Attems, Margaret E Flanagan, Qinwen Mao, M-Marsel Mesulam, Sandra Weintraub, Randy L Woltjer, Thao Pham, Julia Kofler, Julie A Schneider, Lei Yu, Dushyant P Purohit, Vahram Haroutunian, Patrick R Hof, Sam Gandy, Mary Sano, Thomas G Beach, Wayne Poon, Claudia H Kawas, María M Corrada, Robert A Rissman, Jeff Metcalf, Sara Shuldberg, Bahar Salehi, Peter T Nelson, John Q Trojanowski, Edward B Lee, David A Wolk, Corey T McMillan, C Dirk Keene, Caitlin S Latimer, Thomas J Montine, Gabor G Kovacs, Mirjam I Lutz, Peter Fischer, Richard J Perrin, Nigel J Cairns, Ann C McKee, John F Crary
Publikováno v:
Journal of neuropathology and experimental neurology. 81(10)
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites in the depths of the neocortical sulci. In
Autor:
Caitlyn Fastenau, Jessica L. Wickline, Sabrina Smith, Kristian F. Odfalk, Leigh Solano, Kevin F. Bieniek, Sarah C. Hopp
Publikováno v:
GeroScience.
Autor:
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J. Ray, Kevin F. Bieniek, Bess Frost
Publikováno v:
Science advances. 9(1)
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau
Autor:
Caitlyn Fastenau, Leigh Solano, Jessica L Wickline, Sabrina Smith, Kristian F Odfalk, Kevin F Bieniek, Sarah C. Hopp
Publikováno v:
Alzheimer's & Dementia. 18