Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Kevin E. Healy"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract In the initial hours following the application of the calcium channel blocker (CCB) nifedipine to microtissues consisting of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we observe notable variations in the drug’
Externí odkaz:
https://doaj.org/article/0258195002c146189b9d09b1cfacb426
Autor:
Matthew J. Powell-Palm, Verena Charwat, Berenice Charrez, Brian Siemons, Kevin E. Healy, Boris Rubinsky
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants.
Externí odkaz:
https://doaj.org/article/e91e22959744442889b1812d5fc408b0
Autor:
Bérénice Charrez, Verena Charwat, Brian Siemons, Henrik Finsberg, Evan W. Miller, Andrew G. Edwards, Kevin E. Healy
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1155-1165 (2021)
Abstract Only a handful of US Food and Drug Administration (FDA) Emergency Use Authorizations exist for drug and biologic therapeutics that treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection. Potential therapeutics inc
Externí odkaz:
https://doaj.org/article/909a322bfea042109b6b1af1e914fe94
Autor:
Bérénice Charrez, Verena Charwat, Brian A. Siemons, Ishan Goswami, Courtney Sakolish, Yu-Syuan Luo, Henrik Finsberg, Andrew G. Edwards, Evan W. Miller, Ivan Rusyn, Kevin E. Healy
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Despite global efforts, it took 7 months between the proclamation of global SARS-CoV-2 pandemic and the first FDA-approved treatment for COVID-19. During this timeframe, clinicians focused their efforts on repurposing drugs, such as hydroxychloroquin
Externí odkaz:
https://doaj.org/article/24b7f9e303f54de4a211eb7cf95a932a
Autor:
Felipe T. Lee-Montiel, Alexander Laemmle, Verena Charwat, Laure Dumont, Caleb S. Lee, Nathaniel Huebsch, Hideaki Okochi, Matthew J. Hancock, Brian Siemons, Steven C. Boggess, Ishan Goswami, Evan W. Miller, Holger Willenbring, Kevin E. Healy
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ function in vitro are an emerging alternative to conventional monolayer cell culture and animal models for drug development. Human induced pluripotent stem cells (hiPSCs)
Externí odkaz:
https://doaj.org/article/027539b15d064925b90ab47e1ab3702a
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) offer a new means to study and understand the human cardiac action potential, and can give key insight into how compounds may interact with important molecular pathways to d
Externí odkaz:
https://doaj.org/article/9a6ac2446c80499083a66e7eb999985e
Autor:
Karoline Horgmo Jæger, Verena Charwat, Bérénice Charrez, Henrik Finsberg, Mary M. Maleckar, Samuel Wall, Kevin E. Healy, Aslak Tveito
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great potential for drug screening applications. However, their usefulness is limited by the relative immaturity of the cells’ electrophysiological properties as comp
Externí odkaz:
https://doaj.org/article/27f371634cb1449b8021351a68f2a484
Autor:
C. Ian Spencer, Shiro Baba, Kenta Nakamura, Ethan A. Hua, Marie A.F. Sears, Chi-cheng Fu, Jianhua Zhang, Sadguna Balijepalli, Kiichiro Tomoda, Yohei Hayashi, Paweena Lizarraga, Julianne Wojciak, Melvin M. Scheinman, Katriina Aalto-Setälä, Jonathan C. Makielski, Craig T. January, Kevin E. Healy, Timothy J. Kamp, Shinya Yamanaka, Bruce R. Conklin
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 269-281 (2014)
Long-QT syndrome mutations can cause syncope and sudden death by prolonging the cardiac action potential (AP). Ion channels affected by mutations are various, and the influences of cellular calcium cycling on LQTS cardiac events are unknown. To bette
Externí odkaz:
https://doaj.org/article/e99f4cbcfba74440b1ffe91f48d916d9
Publikováno v:
Lab on a chip. 22(22)
Stem-cell derived β cells offer an alternative to primary islets for biomedical discoveries as well as a potential surrogate for islet transplantation. The expense and challenge of obtaining and maintaining functional stem-cell derived β cells call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e6c28a00ea607d3754153df42ca61f
https://pubmed.ncbi.nlm.nih.gov/36305868
https://pubmed.ncbi.nlm.nih.gov/36305868
Autor:
Brian Siemons, Henrik Finsberg, Verena Charwat, Berenice Charrez, Kevin E. Healy, Evan W. Miller, Andrew G. Edwards
Publikováno v:
bioRxiv
Clinical and Translational Science, Vol 14, Iss 3, Pp 1155-1165 (2021)
Clinical and Translational Science, Vol 14, Iss 3, Pp 1155-1165 (2021)
Only a handful of US Food and Drug Administration (FDA) Emergency Use Authorizations exist for drug and biologic therapeutics that treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection. Potential therapeutics include repu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd516d19c4c6661115234c443a06723
https://doi.org/10.1111/cts.13038
https://doi.org/10.1111/cts.13038