Výsledky vyhledávání - "Kevin E. Draves"

Akademický článek

B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease

Autor: Daniela Giordano, Runa Kuley, Kevin E. Draves, Keith B. Elkon, Natalia V. Giltiay, Edward A. Clark

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Purpose and methodsB cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti-BAFF Abs and derivatives have been developed for the treatment of SLE, the s

Externí odkaz: https://doaj.org/article/67567eeee87a41d5a6a34eb30d7fd9a4

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Akademický článek

STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses

Autor: Justin Theophilus Ulrich-Lewis, Kevin E. Draves, Kelsey Roe, Megan A. O’Connor, Edward A. Clark, Deborah Heydenburg Fuller

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

DNA vaccines elicit antibody, T helper cell responses and CD8+ T cell responses. Currently, little is known about the mechanism that DNA vaccines employ to induce adaptive immune responses. Prior studies have demonstrated that stimulator of interfero

Externí odkaz: https://doaj.org/article/7fa6674b841f48979e62717e444a10e7

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Akademický článek

B cell activating factor (BAFF) from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection

Autor: Runa Kuley, Kevin E. Draves, Deborah H. Fuller, Natalia V. Giltiay, Edward A. Clark, Daniela Giordano

Publikováno v: PLoS ONE, Vol 16, Iss 10 (2021)

Mice lacking B cells are more susceptible to S. typhimurium infection. How B cells contribute to protective immunity against Salmonella and what signals drive their activation are still unclear. Neutrophils (Nphs), monocytes (MOs), and dendritic cell

Externí odkaz: https://doaj.org/article/551ba880bd2f4716a39c805e5ffed080

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B cell activating factor (BAFF) from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection

Autor: Deborah H. Fuller, Edward A. Clark, Kevin E. Draves, Daniela Giordano, Runa Kuley, Natalia V. Giltiay

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0259158 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8167dccad8632515fda74ba648958
https://doaj.org/article/a8a17ad0d0d04de1b07f07b7141b5184

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An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Publikováno v: Science Translational Medicine

A prime-only replicating RNA vaccine delivered with lipid inorganic nanoparticles induces neutralizing antibody and T cell responses against SARS-CoV-2 in aged mice and macaques.
The COVID-19 pandemic, caused by infection with the SARS-CoV-2 cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2263abba0147db5c777d937bcde695

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Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1

The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a dramatic and deleterious impact on health services and the global economy. Grim public health statistics highlight the need for vaccines that can rapidly confer protectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ac347f61e55791bacf0fcacb60e391
https://doi.org/10.1101/2020.05.28.121640

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Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs

Autor: Geraldine L. Shu, Kevin E. Draves, Kelsey Roe, Marion Pepper, Edward A. Clark, Daniela Giordano

Publikováno v: J Immunol

Targeting Ags to the CD180 receptor activates both B cells and dendritic cells (DCs) to become potent APCs. After inoculating mice with Ag conjugated to an anti-CD180 Ab, B cell receptors were rapidly internalized. Remarkably, all B cell subsets, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f499bf4b46c5c9852c7daf4b310d1
https://pubmed.ncbi.nlm.nih.gov/31484732

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Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses

Autor: Mehul S. Suthar, Ursula Holder, Lucy B. Young, Michael Gale, Daniela Giordano, Kevin E. Draves, Edward A. Clark, Kelsey Roe

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218928 (2019)

Mitochondrial antiviral signaling protein (MAVS) is a critical innate immune signaling protein that directs the actions of the RIG-I-like receptor (RLR) signaling pathway of RNA virus recognition and initiation of anti-viral immunity against West Nil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42cdcc528d7333771d3860884dfa287
https://pubmed.ncbi.nlm.nih.gov/31242236

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Nitric Oxide Regulates BAFF Expression and T Cell–Independent Antibody Responses

Autor: Kevin E. Draves, Edward A. Clark, Chang Li, Tobias M. Hohl, Daniela Giordano

Publikováno v: The Journal of Immunology. 193:1110-1120

Whereas NO is known to regulate T cell responses, its role in regulating B cell responses remains unclear. Previous studies suggested that inducible NO synthase 2 (NOS2/iNOS) is required for normal IgA Ab responses but inhibits antiviral IgG2a Ab res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9df91860f07813856901e0767babc5f5
https://doi.org/10.4049/jimmunol.1303158

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