Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kevin E Ashelford"'
Autor:
Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Mairian Thomas, Jennifer R Shone, Delyth A Badder, Marc Naven, Kevin E Ashelford, Rachel Hargest, Alan R Clarke, Christina Esdar, Hans-Peter Buchstaller, J Mark Treherne, Sylvia Boj, Bahar Ramezanpour, Dirk Wienke, Leo S Price, Paul H Shaw, Trevor C Dale
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235319 (2020)
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting c
Externí odkaz:
https://doaj.org/article/7afb5fbeb60b440b90aba42a6bfd295c
Autor:
Christina Bronowski, Maria C Fookes, Ruth Gilderthorp, Kevin E Ashelford, Simon R Harris, Amos Phiri, Neil Hall, Melita A Gordon, John Wain, Charles A Hart, Paul Wigley, Nicholas R Thomson, Craig Winstanley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2557 (2013)
Invasive Non-typhoidal Salmonella (iNTS) are an important cause of bacteraemia in children and HIV-infected adults in sub-Saharan Africa. Previous research has shown that iNTS strains exhibit a pattern of gene loss that resembles that of host adapted
Externí odkaz:
https://doaj.org/article/fa3bd041e0dc4ee49a6959fd71a92ac7
Autor:
J Yvette Merga, Nicola J Williams, William G Miller, Andrew J H Leatherbarrow, Malcolm Bennett, Neil Hall, Kevin E Ashelford, Craig Winstanley
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55240 (2013)
Arcobacter butzleri is considered to be an emerging human foodborne pathogen. The completion of an A. butzleri genome sequence along with microarray analysis of 13 isolates in 2007 revealed a surprising amount of diversity amongst A. butzleri isolate
Externí odkaz:
https://doaj.org/article/2884e56c64324418bdcf57f9aec2dfce
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Pre- and Post-validation protein altering somatic variants identified by whole exome sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ce25dbcea6cfd110b3ebffd6c078d0
https://doi.org/10.1158/1078-0432.22468877.v1
https://doi.org/10.1158/1078-0432.22468877.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Purpose: Duodenal polyposis and cancer are important causes of morbidity and mortality in familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). This study aimed to comprehensively characterize somatic genetic changes in FAP and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bec1c9bec923fc598eec7d4581a8e81
https://doi.org/10.1158/1078-0432.c.6527084
https://doi.org/10.1158/1078-0432.c.6527084
Autor:
Andrew Godkin, Awen Gallimore, Richard J. Stanton, Alan L. Parker, Robert Andrews, Kevin E. Ashelford, Adam D. Christian, Simon Phillips, Rachel Hargest, Michael M. Davies, James A. Davies, Stephanie E.A. Burnell, Sarah L. Hulin-Curtis, Yuan Chen, Michelle S. Somerville, Emma Campbell, Alex Greenshields-Watson, Martin J. Scurr
Purpose:Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906d7bca2872e6feb04d0114a8d7a38f
https://doi.org/10.1158/1078-0432.c.6529380.v1
https://doi.org/10.1158/1078-0432.c.6529380.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Summary of the 62 recurrently mutated genes in the exome dataset (supplementary table 2) and the number of mutations identified in each gene. Total numbers of variants in each gene take into account any mutations identified in duplicate adenomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62adb6221b5f63491470fe65c602c8d7
https://doi.org/10.1158/1078-0432.22468871.v1
https://doi.org/10.1158/1078-0432.22468871.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Database of somatic APC mutations reported in FAP and MAP duodenal and colorectal adenomas. NA, Not available. NI, Not identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020dd3dbf75d9991dcb718a7f0d1ca06
https://doi.org/10.1158/1078-0432.22468868.v1
https://doi.org/10.1158/1078-0432.22468868.v1
Autor:
Andrew Godkin, Awen Gallimore, Richard J. Stanton, Alan L. Parker, Robert Andrews, Kevin E. Ashelford, Adam D. Christian, Simon Phillips, Rachel Hargest, Michael M. Davies, James A. Davies, Stephanie E.A. Burnell, Sarah L. Hulin-Curtis, Yuan Chen, Michelle S. Somerville, Emma Campbell, Alex Greenshields-Watson, Martin J. Scurr
Supplementary Figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a9d08172eebc658c3f1923a555eac7
https://doi.org/10.1158/1078-0432.22476354.v1
https://doi.org/10.1158/1078-0432.22476354.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Histogram showing number of validated protein changing somatic variants identified per adenoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1040802bee6a1a1ae545d716a6306af0
https://doi.org/10.1158/1078-0432.22468883
https://doi.org/10.1158/1078-0432.22468883