Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kevin D. Seibert"'
Autor:
Jingyao Wang, Mark R. Berglund, Timothy Braden, Matthew C. Embry, Martin D. Johnson, Stephen R. Groskreutz, Fareed Bhasha Sayyed, Sergey Vladimirovich Tsukanov, Timothy D. White, Ankur Jalan, Kevin D. Seibert, Michael E. Kopach
Publikováno v:
ACS Omega, Vol 7, Iss 50, Pp 46809-46824 (2022)
Externí odkaz:
https://doaj.org/article/0d36177179bf4c10b430c4f3e285bf18
Autor:
Han Xia, Stephen R. Groskreutz, Michael O. Frederick, Michael E. Kopach, Nessa Mullane, Jeffrey T. Lampert, Kevin D. Seibert, Mark A. Strege, Neil J. Kallman, Bradley M. Campbell, Sergey V. Tsukanov, Frank L. Torres Torres, Ashley A. Humenik, Gordon R. Lambertus, Nil Tandogan, Nicholas D. Klitzing, Carmel Condon, Shujauddin M. Changi, Joel R. Calvin, Jennifer McClary Groh, Timothy M. Braden, Marie E. O’Mahony, Juliana Kretsinger, Rachel N. Richey, Stephanie R. Coffin, Laura M. Maguire, Richard D. Spencer, Raymond A. Boyse, Zachary D. Harms, John D. Murphy, Humphrey A. Moynihan, Olivia Gowran
Publikováno v:
Organic Process Research & Development. 25:1628-1636
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2449a6ebf10ca890f8df99ddd862ff5
https://doi.org/10.1021/acs.oprd.1c00108
https://doi.org/10.1021/acs.oprd.1c00108
Autor:
Andrew G. Livingston, Jet Yeo, Seoyeon Chung, Carla V. Luciani, Sergey V. Tsukanov, Michael E. Kopach, Ludmila G. Peeva, Piers R. J. Gaffney, Fernando Albericio, Daeok Kim, Kevin D. Seibert
Publikováno v:
Angewandte Chemie (International Ed. in English)
Herein, a one‐pot liquid phase peptide synthesis featuring iterative addition of amino acids to a “nanostar” support, with organic solvent nanofiltration (OSN) for isolation of the growing peptide after each synthesis cycle is reported. A cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e6f35a3a949c7ed7a3adf6498f85fa
https://doi.org/10.1002/anie.202014445
https://doi.org/10.1002/anie.202014445
Autor:
Hao Sun, Michael O. Frederick, Roger Ryan Rothhaar, Amy C. DeBaillie, Brian Morgan Watson, Carlos Mateos, Leonard L. Winneroski, Carlos Jaramillo, Talbi Kaoudi, Matthew Johnson, Pablo Garcia-Losada, Srinivas Gangula, Peter J. Lindsay-Scott, Steven James Green, Dustin J. Mergott, Dajiang Jing, Marvin M. Hansen, José Eugenio de Diego, Juan A. Rincón, Kevin D. Seibert, Lei Zhang, Jiuyuan Li
Publikováno v:
Organic Process Research & Development. 24:306-314
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd409beaf54c99668ae6510bc63b7fdb
https://doi.org/10.1021/acs.oprd.9b00471
https://doi.org/10.1021/acs.oprd.9b00471
Autor:
Carla V. Luciani, Lindsay A. Hobson, Batool Ahmed Omer, Kevin D. Seibert, Sushil K. Srivastava, Matt E. Popkin, John Lepore
Publikováno v:
Journal of Pharmaceutical Innovation. 14:1-14
A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced Quality by Design (QbD) development of the active pharmaceutical ingredient (API) can lead to differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7d4d6c0bf37c4bd4f9e5ec3ab9ff17
https://doi.org/10.1007/s12247-018-9340-2
https://doi.org/10.1007/s12247-018-9340-2
Autor:
Phil J. Borman, John Lepore, Sushil K. Srivastava, Nathan D. Ide, John Donaubauer, Steven Tymonko, Matt E. Popkin, Lindsay A. Hobson, Kevin D. Seibert, Timothy Curran, Batool Ahmed Omer, Jeffrey M. Kallemeyn, Looker Adam
Publikováno v:
Journal of Pharmaceutical Innovation. 13:367-372
This paper by IQ consortium member companies will describe how the application of the ICH Q11 vision for enhanced QbD development can lead to flexibility through differentiated outcomes for elements of API manufacture, such as the control strategy an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d076d7d103e30887516e50a28d8f9a
https://doi.org/10.1007/s12247-018-9339-8
https://doi.org/10.1007/s12247-018-9339-8
Autor:
Erwin Irdam, Christopher J. Welch, Aaron S. Cote, Jean W. Tom, Pierre Boulas, Joel M. Hawkins, Kenneth M. Wells, Charles D. Papageorgiou, David Dermot Patrick Laffan, Margaret M. Faul, Purdie Mark, Rahn McKeown, Scott A. May, Steven J. Wittenberger, Srinivas Tummala, Kevin D. Seibert, Nicholas Murray Thomson, Frederick Hicks, Antonio Christian Ferretti, Paul Frank Fernandez, Keith Horspool, Shailendra Bordawekar, Bing-Shiou Yang
Publikováno v:
Organic Process Research & Development. 21:414-419
The creation of the Enabling Technologies Consortium (ETC) is described. The ETC fosters precompetitive collaborations aimed at the development and evaluation of new enabling technologies for pharmaceutical research and development, with an initial f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf381c2d7be47db5f43a4d433973b1db
https://doi.org/10.1021/acs.oprd.6b00427
https://doi.org/10.1021/acs.oprd.6b00427
Publikováno v:
Organic Process Research & Development. 19:1012-1023
Following a model-centric strategy in the development of a manufacturing process for a new medicine empowers the simultaneous study of a large number of process parameters, which is large enough to exceed the capability of a graphic representation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76be38fb976887c9c7fa3ad71e8ed3d
https://doi.org/10.1021/acs.oprd.5b00158
https://doi.org/10.1021/acs.oprd.5b00158
Autor:
Nicholas Murray Thomson, John Lepore, Carla V. Luciani, Sushil K. Srivastava, Erwin Irdam, Robert A. Singer, Kevin D. Seibert, William F. Kiesman, Luke Schenck
Publikováno v:
Organic Process Research & Development. 19:935-948
A series of case histories from IQ consortium member companies are presented in order to exemplify many of the different elements of drug substance control strategies that are required in order to ensure process performance and product quality. Contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c9cef8f5be7697fc374b346e5194b4
https://doi.org/10.1021/acs.oprd.5b00146
https://doi.org/10.1021/acs.oprd.5b00146