Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kevin D. Noson"'
Autor:
John L. Kane, Junkai Liao, Kevin D. Noson, Gary Asmussen, Yibin Xiang, Maria Fitzgerald, Christine Klaus, Bradford H. Hirth, Michael Booker, Christopher Yee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4550-4554
Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369c9d41ca3e07b0818f4eabf2709c0f
https://doi.org/10.1016/j.bmcl.2010.06.019
https://doi.org/10.1016/j.bmcl.2010.06.019
Autor:
Gary Asmussen, Yibin Xiang, John L. Kane, Bradford H. Hirth, Christopher Yee, Kevin D. Noson, Michael Booker, Junkai Liao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6119-6121
Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a347c182cf62373121f9b662ce5ea70
https://doi.org/10.1016/j.bmcl.2009.09.022
https://doi.org/10.1016/j.bmcl.2009.09.022