Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kevin D. McCarty"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9020 (2024)
Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO3+). Several of the steroid t
Externí odkaz:
https://doaj.org/article/360b5c5b8f9b41ccb18e32215ad5370d
Publikováno v:
Medicinal Chemistry Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6aeef400a6e2ba6b89cf9a1ff9d05a
https://doi.org/10.1007/s00044-023-03078-y
https://doi.org/10.1007/s00044-023-03078-y
Autor:
Jeffrey Y Jian, Kevin D McCarty, Jo Ann W Byl, F Peter Guengerich, Keir C Neuman, Neil Osheroff
Publikováno v:
Nucleic Acids Res
To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this complex is a requisite enzyme intermediate, it is also intrinsically dangerous to genomic stability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a00dba8a24a38260445f90e51df0603
https://europepmc.org/articles/PMC10164583/
https://europepmc.org/articles/PMC10164583/
Autor:
Kevin D. McCarty, Molly E. Sullivan, Yasuhiro Tateishi, Tatiana Y. Hargrove, Galina I. Lepesheva, F. Peter Guengerich
Publikováno v:
Journal of Biological Chemistry. :104841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::403d5f148d04a14d4dd7df5a84ebc0f7
https://doi.org/10.1016/j.jbc.2023.104841
https://doi.org/10.1016/j.jbc.2023.104841
Publikováno v:
Drug Metab Dispos
Cytochrome P450 2D6 (CYP2D6) is a major drug metabolizing enzyme with a buried active site. Channels leading to the active site from various enzyme surfaces are believed to facilitate ligand egress and access to the active site. The present study use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39087250a8bd472050e2502639c7238d
https://doi.org/10.1124/dmd.120.000274
https://doi.org/10.1124/dmd.120.000274
Publikováno v:
The Journal of Biological Chemistry
It has been recognized for >50 years that cytochrome b5 (b5) stimulates some cytochrome P450 (P450)–catalyzed oxidations, but the basis of this function is still not understood well. The strongest stimulation of catalytic activity by b5 is in the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccf472b89ee4d1e1f4cb7aecf7ad72f
http://europepmc.org/articles/PMC8080067
http://europepmc.org/articles/PMC8080067
Publikováno v:
The Journal of Biological Chemistry
Cytochrome P450 (P450) 3A4 is the enzyme most involved in the metabolism of drugs and can also oxidize numerous steroids. This enzyme is also involved in one-half of pharmacokinetic drug–drug interactions, but details of the exact mechanisms of P45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c374ce6dab0046618d2955583b1acc6
https://pubmed.ncbi.nlm.nih.gov/33449875
https://pubmed.ncbi.nlm.nih.gov/33449875
Publikováno v:
The Journal of Biological Chemistry
Cytochrome P450 (P450) 17A1 catalyzes the 17α-hydroxylation of progesterone and pregnenolone as well as the subsequent lyase cleavage of both products to generate androgens. However, the selective inhibition of the lyase reactions, particularly with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce22af5eca53b1aaba935d18335793d
https://doi.org/10.1016/j.jbc.2021.100969
https://doi.org/10.1016/j.jbc.2021.100969
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d19c4ea4377858836a0786d4fb9cfe9
https://doi.org/10.1096/fasebj.2020.34.s1.03570
https://doi.org/10.1096/fasebj.2020.34.s1.03570