Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kevin D. Lominac"'
Autor:
Michael C. Datko, Jia-Hua Hu, Melanie Williams, Cindy M. Reyes, Kevin D. Lominac, Georg von Jonquieres, Matthias Klugmann, Paul F. Worley, Karen K. Szumlinski
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 11 (2017)
Immediate early and constitutively expressed products of the Homer1 gene regulate the functional assembly of post-synaptic density proteins at glutamatergic synapses to influence excitatory neurotransmission and synaptic plasticity. Earlier studies o
Externí odkaz:
https://doaj.org/article/a8047bee6f2843c084d464df2b3a80ef
Autor:
Kevin D Lominac, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh eRajasekar, Dan eMaliniak, Andrew B Thompson, Lawrence E Urman, Tamara ePhillips, Karen K Szumlinski
Publikováno v:
Frontiers in Systems Neuroscience, Vol 8 (2014)
Methamphetamine (MA) is a highly addictive psychomotor stimulant, with life-time prevalence rates of abuse ranging from 5-10% world-wide. Yet, a paucity of research exists regarding MA addiction vulnerability/resiliency and neurobiological mediators
Externí odkaz:
https://doaj.org/article/8cbae492ae28499f97fa7dade4c22b96
Publikováno v:
Brain Research. 1748:147098
For over 50 years, the sympathomimetic phenylpropanolamine (PPA; ±-norephedrine) was a primary active ingredient in over-the-counter nasal decongestants for both children and adults and continues to be prevalent in the vast majority of countries tod
Autor:
Jonathan M. Turner, Krittika Krishnan, Tomoko Hattori, Victoria L. Nutsch, Kevin D. Lominac, Ryan G. Will, Daniel J. Tobiansky, Julia R. Martz, Juan M. Dominguez
Publikováno v:
Neuropsychopharmacology
The sex-steroid hormone estradiol (E2) enhances the psychoactive effects of cocaine, as evidenced by clinical and preclinical studies. The medial preoptic area (mPOA), a region in the hypothalamus, is a primary neural locus for neuroendocrine integra
Autor:
Arshad Haider, Karen K. Szumlinski, Arianne D. Sacramento, Richard L. Bell, Kevin D. Lominac, Matthias Klugmann, Nicholas C. Woodward
Publikováno v:
Haider, A; Woodward, NC; Lominac, KD; Sacramento, AD; Klugmann, M; Bell, RL; et al.(2015). Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats. Alcohol. doi: 10.1016/j.alcohol.2015.03.009. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/5hm6b968
Alcohol (Fayetteville, N.Y.), vol 49, iss 6
Alcohol (Fayetteville, N.Y.), vol 49, iss 6
© 2015 Elsevier Inc. In murine models of alcoholism, the glutamate receptor scaffolding protein Homer2 bidirectionally regulates alcohol intake. Although chronic alcohol drinking increases Homer2 expression within the core subregion of the nucleus a
Autor:
Elissa K. Fultz, Kevin D. Lominac, Matthias Klugmann, Georg von Jonquieres, Matan Cohen, Sema G. Quadir, Tamara J. Phillips, Bailey W. Miller, Rianne R. Campbell, Andrew B. Thompson, Tod E. Kippin, Karen K. Szumlinski, Douglas L. Martin, Chelsea N. Brown
Publikováno v:
Biological psychiatry, vol 81, iss 11
BackgroundThe high prevalence and severity of methamphetamine (MA) abuse demands greater neurobiological understanding of its etiology.MethodsWe conducted immunoblotting and in vivo microdialysis procedures in MA high/low drinking mice, as well as in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54db974454592a0a82b50e189945c2dd
https://escholarship.org/uc/item/3zp446pc
https://escholarship.org/uc/item/3zp446pc
Autor:
Georg von Jonquieres, Rianne R. Campbell, Melissa G. Wroten, Kevin D. Lominac, Karen K. Szumlinski, Amy R. Williams, Osnat Ben-Shahar, Alexis W. Ary, Matthias Klugmann
Publikováno v:
The Journal of Neuroscience. 33:8101-8113
Homer postsynaptic scaffolding proteins regulate forebrain glutamate transmission and thus, are likely molecular candidates mediating hypofrontality in addiction. Protracted withdrawal from cocaine experience increases the relative expression of Home
Autor:
Ahmad N. Nabhan, Jeremy DeMartini, Ami Cohen, Arianne D. Sacramento, Osnat Ben-Shahar, Karen K. Szumlinski, Nick Woodward, Nicole M. Rudy, Giovanni A. Carosso, Kyle L. Ploense, Kelly Pagano, Evan Gordon, Nicholas Bernstein, Kevin D. Lominac
Publikováno v:
Addiction Biology. 17:746-757
Previous studies have shown that brief access to cocaine yields an increase in D2 receptor binding in the medial prefrontal cortex (mPFC), but that extended access to cocaine results in normalized binding of D2 receptors (i.e. the D2 binding returned
Autor:
Gregor McIver, Andrew C. McCreary, Kevin D. Lominac, Avi E. Zayara, Karen K. Szumlinski, Paola N. Valdivia
Publikováno v:
Psychopharmacology
Zayara, Avi E.; McIver, Gregor; Valdivia, Paola N.; Lominac, Kevin D.; McCreary, Andrew C.; & Szumlinski, Karen K.(2011). Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Psychopharmacology, 213(2), pp 321-335. doi: 10.1007/s00213-010-1996-3. Retrieved from: http://www.escholarship.org/uc/item/3qr6g2jw
Zayara, Avi E.; McIver, Gregor; Valdivia, Paola N.; Lominac, Kevin D.; McCreary, Andrew C.; & Szumlinski, Karen K.(2011). Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Psychopharmacology, 213(2), pp 321-335. doi: 10.1007/s00213-010-1996-3. Retrieved from: http://www.escholarship.org/uc/item/3qr6g2jw
Rationale The serotonin 5-HT2A and 5-HT2C receptors regulate the capacity of acute cocaine to augment behavior and monoamine levels within the nucleus accumbens (NAC), a brain region involved in cocaine’s addictive and psychotogenic properties. Obj
Publikováno v:
Biochemical Pharmacology. 75:112-133
Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic pred