Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin D. Dong"'
Autor:
Aaron A. Smargon, Assael A. Madrigal, Brian A. Yee, Kevin D. Dong, Jasmine R. Mueller, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The off-target effects of CRISPR-Cas9 are thought to be mediated by its cognate guide RNA. Here the authors show that Cas9 independently interacts with the human transcriptome, correlating with elevated RNA editing even under guide RNA co-expression.
Externí odkaz:
https://doaj.org/article/c41abe7312ab41079c5067ddeabb873b
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108350- (2020)
Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA mo
Externí odkaz:
https://doaj.org/article/a4f35ebdfeda4d2e94032f5c03770e2e
Autor:
Pratibha Jagannatha, Kevin D. Dong, Eric Kofman, Ryan J. Marina, Assael A. Madrigal, Jason G. Underwood, Isaac A. Chaim, Brian A. Yee, Gene W. Yeo, Daniel A. Lorenz, Kristopher W. Brannan
Publikováno v:
Nature methods
RNA-binding proteins (RBPs) are critical regulators of gene expression and RNA processing that are required for gene function. Yet the dynamics of RBP regulation in single cells is unknown. To address this gap in understanding, we developed STAMP (Su
Autor:
Joy S. Xiang, Jasmine R. Mueller, En-Ching Luo, Brian A. Yee, Danielle Schafer, Jonathan C. Schmok, Frederick E. Tan, Katherine Rothamel, Rachael N. McVicar, Elizabeth M. Kwong, Krysten L. Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Q. Vu, Wenhao Jin, Samuel S. Park, Phuong Le, Kristopher W. Brannan, Eric R. Kofman, Yanhua Li, Alexandra T. Tankka, Kevin D. Dong, Yan Song, Aaron F. Carlin, Eric L. Van Nostrand, Sandra L. Leibel, Gene W. Yeo
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipita
Autor:
En-Ching Luo, Anthony Q. Vu, Eric Kofman, Sandra L Leibel, Aaron F. Carlin, Eric L. Van Nostrand, Jonathan C. Schmok, Elizabeth M. Kwong, Danielle Schafer, Brian A. Yee, Gene W. Yeo, Jasmine R. Mueller, Frederick E. Tan, Joy Shengnan Xiang, Yan Song, Kristopher W. Brannan, Alexandra T. Tankka, Yanhua Li, Phuong Le, Kevin D. Dong, Hsuan-Lin Her, Samuel S. Park, Krysten Leigh Jones, Rachael N. McVicar, Chun-Yuan Chen, Wenhao Jin
Publikováno v:
SSRN Electronic Journal.
The COVID-19 pandemic was caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs. SARS-CoV-2 proteins,
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108350-(2020)
Cell Rep
Cell Rep
Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules i