Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kevin D. Burris"'
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a148f5b308f73f0b2bd16ea57df7708
https://doi.org/10.1124/jpet.118.250126
https://doi.org/10.1124/jpet.118.250126
Autor:
Benjamin Wilenkin, Brian J. Eastwood, Emanuele Sher, Birgit T. Priest, Andrew Caerwyn Williams, Kevin D. Burris
Publikováno v:
Assay and drug development technologies. 17(7)
Relief from chronic pain continues to represent a large unmet need. The voltage-gated potassium channel Kv7.2/7.3, also known as KCNQ2/3, is a key contributor to the control of resting membrane potential and excitability in nociceptive neurons and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4d1b91e38bd3e0557f0b0da078a9a3
https://pubmed.ncbi.nlm.nih.gov/31634018
https://pubmed.ncbi.nlm.nih.gov/31634018
Autor:
Akihiko Kato, Hong Yu, Stephen M. Fitzjohn, Francesca Pasqui, Thomas E. Fitch, Yue-Wei Qian, Jon K. Reel, Chunjin Ding, Ruud Zwart, He Wang, Keith A. Wafford, Paul L. Ornstein, Kurt Rasmussen, Matthew Lee, John T.R. Isaac, Kevin D. Burris, Scott D. Gleason, Warren J. Porter, David S. Bredt, Douglas A. Schober, John T. Catlow, Jeffrey M. Witkin, Beverly A. Heinz, Kevin Matthew Gardinier, Emanuele Sher, Douglas Linn Gernert, Yuan Tu, Eric S. Nisenbaum
Publikováno v:
Nature Medicine. 22:1496-1501
Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc9375065e97d80f12aadd0767c0493
https://doi.org/10.1038/nm.4221
https://doi.org/10.1038/nm.4221
Publikováno v:
ASSAY and Drug Development Technologies. 14:75-83
Voltage-gated calcium channels represent important drug targets. The implementation of higher throughput electrophysiology assays is necessary to characterize the interaction of test compounds with several conformational states of the channel, but ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bc50c79b04f428040c0c7c09dc687e
https://doi.org/10.1089/adt.2015.678
https://doi.org/10.1089/adt.2015.678
Publikováno v:
ASSAY and Drug Development Technologies. 14:84-92
Voltage-gated sodium channels represent important drug targets. The implementation of higher throughput electrophysiology assays is necessary to characterize the interaction of test compounds with several conformational states of the channel, but has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a4a2399f8374bbbd648435eeadd24e
https://doi.org/10.1089/adt.2015.677
https://doi.org/10.1089/adt.2015.677
Autor:
Kelly L, Knopp, Rosa Maria A, Simmons, Wenhong, Guo, Benjamin L, Adams, Kevin M, Gardinier, Douglas L, Gernert, Paul L, Ornstein, Warren, Porter, Jon, Reel, Chunjin, Ding, He, Wang, Yuewei, Qian, Kevin D, Burris, Anne, Need, Vanessa, Barth, Steven, Swanson, John, Catlow, Jeffrey M, Witkin, Ruud, Zwart, Emanuele, Sher, Kar-Chan, Choong, Theron M, Wall, Douglas, Schober, Christian C, Felder, Akihiko S, Kato, David S, Bredt, Eric S, Nisenbaum
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(3)
Nonselective glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0442d2d88bd4a44909afda3d2015420
https://pubmed.ncbi.nlm.nih.gov/30910921
https://pubmed.ncbi.nlm.nih.gov/30910921
Autor:
Thaddeus F. Molski, Kevin D. Burris, Tanaz Mistry Kannan, Kelly A. Allers, Shaun Jordan, Tetsuro Kikuchi, Frank D. Yocca, Arlene Stark, Trevor Sharp, Robert L. Bertekap, Ruoyan Chen
BACKGROUND: Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone) is a novel antipsychotic with a mechanism of action that differs from current typical and atypical antipsychotics. Aripiprazole interacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31f87dc2f0b84e111aac6e450c3378d
https://doi.org/10.1007/s00213-006-0621-y
https://doi.org/10.1007/s00213-006-0621-y
Autor:
Hong Yu, Sean P. Hollinshead, Anne B. Need, Akihiko Kato, Daniel Ray Mayhugh, Diseroad Benjamin Alan, Paul L. Ornstein, Jon K. Reel, Patrick Gianpietro Spinazze, Jeff Schkeryantz, David S. Bredt, Oscar de Frutos, Beverly A. Heinz, Kevin Matthew Gardinier, Debra Luffer-Atlas, F. Craig Stevens, Vanessa N. Barth, Warren J. Porter, Timothy Andrew Woods, Douglas Linn Gernert, Gregory A. Stephenson, Jeffrey M. Witkin, Kevin D. Burris, Prashant V. Desai, Patric James Hahn, Scott D. Gleason, Steven Swanson, Chunjin Ding, Albert Khilevich
Publikováno v:
Journal of medicinal chemistry. 59(10)
Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f6a1cbca71f336baac901c8fde85e1
https://pubmed.ncbi.nlm.nih.gov/27067148
https://pubmed.ncbi.nlm.nih.gov/27067148
Autor:
Steven I. Dworetzky, Kevin D. Burris
Publikováno v:
Journal of biomolecular screening. 21(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2234101705c1b9ff0074855fd7f00178
https://pubmed.ncbi.nlm.nih.gov/27439661
https://pubmed.ncbi.nlm.nih.gov/27439661
Autor:
Gene M. Dubowchik, Kaitlin E. Browman, Lynn A. Balanda, Kevin D. Burris, John E. Macor, Bireshwar Dasgupta, Sokhom S. Pin, Vivekananda M. Vrudhula, Lawrence K. Fung, Matthew T. Taber, Tracey Fiedler, Jie Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1905-1909
Several tetrahydroimidazopyrimidines were prepared using silver assisted cyclization as the key step. The binding affinities of compounds thus prepared were evaluated in vitro toward hCRF(1)R. Initial lead compound 16 (K(i)=32 nM) demonstrated modest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7fd258ce27ad91ced45f6db8058fc7
https://doi.org/10.1016/j.bmcl.2010.01.127
https://doi.org/10.1016/j.bmcl.2010.01.127