Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Kevin D. Bunting"'
Autor:
Zhengqi Wang, Tian Mi, Heath L. Bradley, Jonathan Metts, Himalee Sabnis, Wandi Zhu, Jack Arbiser, Kevin D. Bunting
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 956 (2021)
Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway
Externí odkaz:
https://doaj.org/article/55cef3b857214f6c9597debf32e669f4
Autor:
Jonathan Metts, Heath L. Bradley, Zhengqi Wang, Neil P. Shah, Reuben Kapur, Jack L. Arbiser, Kevin D. Bunting
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, howev
Externí odkaz:
https://doaj.org/article/194b5d0b84eb4fd8aa2867b88dfc9dc5
Autor:
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8+ T-cells, but little is known about their mechanism of activation during initiation of colitis. Here, Grb2-associate
Externí odkaz:
https://doaj.org/article/2a6344e317274854947962fedcc832e3
Autor:
Anindya Chatterjee, Joydeep Ghosh, Baskar Ramdas, Raghuveer Singh Mali, Holly Martin, Michihiro Kobayashi, Sasidhar Vemula, Victor H. Canela, Emily R. Waskow, Valeria Visconte, Ramon V. Tiu, Catherine C. Smith, Neil Shah, Kevin D. Bunting, H. Scott Boswell, Yan Liu, Rebecca J. Chan, Reuben Kapur
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1333-1348 (2014)
Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been impl
Externí odkaz:
https://doaj.org/article/3fb0e4f417624b859de3a4859396cf8a
Publikováno v:
Cancers, Vol 10, Iss 10, p 359 (2018)
Reactive oxygen species (ROS) are now recognized as important second messengers with roles in many aspects of signaling during leukemogenesis. They serve as critical cell signaling molecules that regulate the activity of various enzymes including tyr
Externí odkaz:
https://doaj.org/article/5a81775dc95941b39b1c5339442fb76a
Autor:
Kevin D. Bunting, Robert G. Hawley
Publikováno v:
The Scientific World Journal, Vol 2, Pp 983-995 (2002)
Hematopoietic stem cells (HSCs) are the best studied of the tissue-specific stem cells. By definition, HSCs have long been regarded as restricted to formation of blood cells of both the lymphoid and myeloid lineages. HSCs residing in the bone marrow
Externí odkaz:
https://doaj.org/article/6b8753d5f19545da99a5eddb5f9c9054
Publikováno v:
Genes, Vol 8, Iss 4, p 114 (2017)
Abstract: MYC is a critical growth regulatory gene that is commonly overexpressed in a wide range of cancers. Therapeutic targeting of MYC transcriptional activity has long been a goal, but it has been difficult to achieve with drugs that directly bl
Externí odkaz:
https://doaj.org/article/6983850aba874b3881334883c0f9a41b
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targe
Externí odkaz:
https://doaj.org/article/a3c807d4cc7147a0ab0d4962d471ff00
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, G
Externí odkaz:
https://doaj.org/article/3dbadba4a6444f9ebb9c36efa8930922
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/8470504b18c44c2982f3aec7ccfd89b2