Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kevin D. Broad"'
Autor:
Kevin D. Broad, Igor Fierens, Bobbi Fleiss, Eridan Rocha-Ferreira, Mojgan Ezzati, Jane Hassell, Daniel Alonso-Alconada, Alan Bainbridge, Go Kawano, Daqing Ma, Ilias Tachtsidis, Pierre Gressens, Xavier Golay, Robert D. Sanders, Nicola J. Robertson
Publikováno v:
Neurobiology of Disease, Vol 87, Iss , Pp 29-38 (2016)
Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection. Following hypoxia–ischemia we assessed whether inhaled 45–50% Argon from
Externí odkaz:
https://doaj.org/article/1f2df732f28b4bcc9885f28dd3d854da
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
The evolution of intrauterine development, vivipary, and placentation in eutherian mammals has introduced new possibilities and constraints in the regulation of neural plasticity and development which promote neural function that is adaptive to the e
Externí odkaz:
https://doaj.org/article/cb3a610319b64cdf8c6652c467b4cd67
Autor:
Kevin D Broad, Go Kawano, Igor Fierens, Eridan Rocha-Ferreira, Mariya Hristova, Mojgan Ezzati, Jamshid Rostami, Daniel Alonso-Alconada, Badr Chaban, Jane Hassell, Bobbi Fleiss, Pierre Gressens, Robert D Sanders, Nicola J Robertson
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173413 (2017)
In a range of animal species, exposure of the brain to general anaesthesia without surgery during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex but include an increase in brain cell
Externí odkaz:
https://doaj.org/article/30006c7cc5bb4a509a7beb94ccf4e8cd
Autor:
Kevin D Broad, Jane Hassell, Bobbi Fleiss, Go Kawano, Mojgan Ezzati, Eridan Rocha-Ferreira, Mariya Hristova, Kate Bennett, Igor Fierens, Ryan Burnett, Badr Chaban, Daniel Alonso-Alconada, Aaron Oliver-Taylor, Ilias Tachsidis, Jamshid Rostami, Pierre Gressens, Robert D Sanders, Nicola J Robertson
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166784 (2016)
Exposure of the brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex, incompletely understood and may be sexually dimorphic, but include developmentally
Externí odkaz:
https://doaj.org/article/2926425d15624b2a91537a95ff20be63
Autor:
Xueqing Zou, Elizabeth Price, Mandeep S. Sagoo, Kevin D. Broad, Ibrahim Sheriff, Irene Scheimberg, Esin Kotiloglu Karaa, M. Ashwin Reddy, Helen Davies, Zerrin Onadim, Shin-ichi Ohnuma, Serena Nik-Zainal
Publikováno v:
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 754, p 754 (2021)
Volume 13
Issue 4
Cancers, Vol 13, Iss 754, p 754 (2021)
Simple Summary Retinoblastoma, a childhood cancer of the eye, is thought to be caused by inactivating mutations of both copies of the RB1 gene. The majority of RB1 mutations can be detected by clinical screening. However, retinoblastoma cases exist w
Autor:
Xavier Golay, Aaron Oliver-Taylor, I Fierens, M Ezzati, Pierre Gressens, Daniel Alonso-Alconada, Kate Bennett, Nicola J. Robertson, Derek M. Yellon, Alan Bainbridge, Ilias Tachtsidis, Bobbi Fleiss, Kevin D. Broad, Jamshid Rostami, Sophie Lebon, K Jane Hassell, Mariya Hristova, Derek J. Hausenloy, Eridan Rocha-Ferreira, G Kawano
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Ezzati, M, Bainbridge, A, Broad, K D, Kawano, G, Oliver-Taylor, A, Rocha-Ferreira, E, Alonso-Alconada, D, Fierens, I, Rostami, J, Jane Hassell, K, Tachtsidis, I, Gressens, P, Hristova, M, Bennett, K, Lebon, S, Fleiss, B, Yellon, D, Hausenloy, D J, Golay, X & Robertson, N J 2015, ' Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter ', Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X15608862
Ezzati, M, Bainbridge, A, Broad, K D, Kawano, G, Oliver-Taylor, A, Rocha-Ferreira, E, Alonso-Alconada, D, Fierens, I, Rostami, J, Jane Hassell, K, Tachtsidis, I, Gressens, P, Hristova, M, Bennett, K, Lebon, S, Fleiss, B, Yellon, D, Hausenloy, D J, Golay, X & Robertson, N J 2015, ' Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter ', Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X15608862
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. Our aim was t
Autor:
Xavier Golay, Mariya Hristova, Aron Kerenyi, Eridan Rocha-Ferreira, Jane Hassell, Alan Bainbridge, Stuart D Faulkner, D Kelen, Daniel Alonso-Alconada, Nicola J. Robertson, Ernest B. Cady, Kevin D Broad, M Chandrasekaran, Kate Bennett, Bobbi Fleiss, Pierre Gressens
Publikováno v:
Stroke. 46:275-278
Background and Purpose— In infants with moderate to severe neonatal encephalopathy, whole-body cooling at 33°C to 34°C for 72 hours is standard care with a number needed to treat to prevent a adverse outcome of 6 to 7. The precise brain temperatu
Autor:
Ernest B. Cady, Kevin D. Broad, Ilias Tachtsidis, Xavier Golay, Esther Baer, Nicola J. Robertson, Alan Bainbridge, D Price, Stuart Faulkner, David L. Thomas, Tingting Zhu
Publikováno v:
Neuroimage
Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of cerebral mitochondrial cytochrome-c-oxid
Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model
Autor:
I Fierens, Jane Hassell, Robert D. Sanders, Majid Ezzati, Bobbi Fleiss, Kevin D. Broad, Jamshid Rostami, Stuart Faulkner, Nicola J. Robertson, Brian J. Anderson, Pierre Gressens, G Kawano, Mervyn Maze, James W. Sleigh
Publikováno v:
Acta Anaesthesiologica Scandinavica. 58:733-742
The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuropr
Autor:
Xavier Golay, Kevin D. Broad, Ilias Tachtsidis, Bobbi Fleiss, Pardis Kaynezhad, Daniel Alonso-Alconada, Jane Hassell, Eridan Rocha-Ferreira, Mariya Hristova, I Fierens, G Kawano, Alan Bainbridge, Nicola J. Robertson, Brian Anderson, Robert D. Sanders, D Price, M Ezzati, Pierre Gressens
Publikováno v:
Ezzati, M, Kawano, G, Rocha-Ferreira, E, Alonso-Alconada, D, Hassell, J K, Broad, K D, Fierens, I, Fleiss, B, Bainbridge, A, Price, D L, Kaynezhad, P, Anderson, B, Hristova, M, Tachtsidis, I, Golay, X, Gressens, P, Sanders, R D & Robertson, N J 2017, ' Dexmedetomidine Combined with Therapeutic Hypothermia Is Associated with Cardiovascular Instability and Neurotoxicity in a Piglet Model of Perinatal Asphyxia ', Developmental Neuroscience . https://doi.org/10.1159/000458438
The selective α2-adrenoreceptor agonist dexmedetomidine has shown neuroprotective, analgesic, anti-inflammatory, and sympatholytic properties that may be beneficial in neonatal encephalopathy (NE). As therapeutic hypothermia is only partially effect