Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Kevin D Read"'
Autor:
Franz S Gruber, Anthony Richardson, Zoe C Johnston, Rachel Myles, Neil R Norcross, David P Day, Irene Georgiou, Laura Sesma-Sanz, Caroline Wilson, Kevin D Read, Sarah Martins da Silva, Christopher L R Barratt, Ian H Gilbert, Jason R Swedlow
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297666 (2024)
Male contraceptive options and infertility treatments are limited, and almost all innovation has been limited to updates to medically assisted reproduction protocols and methods. To accelerate the development of drugs that can either improve or inhib
Externí odkaz:
https://doaj.org/article/f2f5d29a721e4ad38c065b5e3404a1c2
Autor:
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Autor:
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006850 (2018)
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However
Externí odkaz:
https://doaj.org/article/15b9266be10f461686b0efc0aad70326
Autor:
Susan Wyllie, Adam J Roberts, Suzanne Norval, Stephen Patterson, Bernardo J Foth, Matthew Berriman, Kevin D Read, Alan H Fairlamb
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005971 (2016)
Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treat
Externí odkaz:
https://doaj.org/article/a48909d39e464a929a528cc874527d3f
Autor:
Stephen Patterson, Susan Wyllie, Suzanne Norval, Laste Stojanovski, Frederick RC Simeons, Jennifer L Auer, Maria Osuna-Cabello, Kevin D Read, Alan H Fairlamb
Publikováno v:
eLife, Vol 5 (2016)
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania
Externí odkaz:
https://doaj.org/article/830d1f9ce1e54963993ed6b35157f836
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004014 (2015)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life threatening global health problem with only two drugs available for treatment (benznidazole and nifurtimox), both having variable efficacy in the chronic stage o
Externí odkaz:
https://doaj.org/article/e1fba0f7f43045deb3d5a8e5c05870d0
Autor:
Katrin Hack, Louise Reilly, Colin Palmer, Kevin D Read, Suzanne Norval, Robert Kime, Kally Booth, John Foerster
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37097 (2012)
We have previously shown that peroxisome proliferator activating receptor ß/δ (PPAR β/δ is overexpressed in psoriasis. PPAR β/δ is not present in adult epidermis of mice. Targeted expression of PPAR β/δ and activation by a selective synthetic
Externí odkaz:
https://doaj.org/article/5e464c15485647c3b214801eaed238d6
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Autor:
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
Externí odkaz:
https://doaj.org/article/0a27546e2eeb4807bfe33c85491f6518
Autor:
Erwan Beauchamp, Megan C. Yap, Aishwarya Iyer, Maneka A. Perinpanayagam, Jay M. Gamma, Krista M. Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M. Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, John R. Mackey, Luc G. Berthiaume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatme
Externí odkaz:
https://doaj.org/article/bfdadd6d979a442fbc358345f3c1fc33