Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Kevin D Raney"'
Autor:
Zebin Hong, Alicia K. Byrd, Jun Gao, Poulomi Das, Vanessa Qianmin Tan, Emory G. Malone, Bertha Osei, John C. Marecki, Reine U. Protacio, Wayne P. Wahls, Kevin D. Raney, Haiwei Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract G-quadruplexes (G4s) formed by guanine-rich nucleic acids induce genome instability through impeding DNA replication fork progression. G4s are stable DNA structures, the unfolding of which require the functions of DNA helicases. Pif1 helicas
Externí odkaz:
https://doaj.org/article/6aa4d3692290417997fffad10f0dc839
Autor:
Nannan Su, Alicia K. Byrd, Sakshibeedu R. Bharath, Olivia Yang, Yu Jia, Xuhua Tang, Taekjip Ha, Kevin D. Raney, Haiwei Song
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insigh
Externí odkaz:
https://doaj.org/article/96ab66ada22747c98c3f99197371f70c
Autor:
Zachary J. Waldrip, Piroon Jenjaroenpun, Oktawia DeYoung, Intawat Nookaew, Sean D. Taverna, Kevin D. Raney, Alan J. Tackett
Publikováno v:
PeerJ, Vol 8, p e9442 (2020)
The CRISPR system has become heavily utilized in biomedical research as a tool for genomic editing as well as for site-specific chromosomal localization of specific proteins. For example, we developed a CRISPR-based methodology for enriching a specif
Externí odkaz:
https://doaj.org/article/874fb67cc00c45098bd7b8f7361d3d6a
Autor:
Senthil K. Perumal, David K Harrison, Kevin D. Raney, Maroof K. Zafar, Alicia K. Byrd, Matthew D. Thompson, Lindsey Hazeslip, Emory G Malone, Jun Gao, John C. Marecki
Publikováno v:
Protein Sci
Helicases are molecular motors with many activities. They use the energy from ATP hydrolysis to unwind double‐stranded nucleic acids while translocating on the single‐stranded DNA. In addition to unwinding, many helicases are able to remove prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3949cbfc0fba0b16f5b296a1eb8fa432
https://doi.org/10.1002/pro.4232
https://doi.org/10.1002/pro.4232
Autor:
Kevin D. Raney, Andrea Putnam, John C. Marecki, Andrea D Edwards, Jun Gao, Zhaofeng Gao, Eckhard Jankowsky, Sarah Venus, Haley M Lowe, Alicia K. Byrd
Publikováno v:
Chemical Communications (Cambridge, England)
G-quadruplex DNA interacts with the N-terminal intrinsically disordered domain of the DEAD-box helicase Ded1p, diminishing RNA unwinding activity but enhancing liquid–liquid phase separation of Ded1p in vitro and in cells. The data highlight multif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11661fa8c8afea4fdafe1ad9de386f51
https://doi.org/10.1039/d1cc01479j
https://doi.org/10.1039/d1cc01479j
Publikováno v:
Nucleic Acids Research
G-Quadruplexes are non-B form DNA structures present at regulatory regions in the genome, such as promoters of proto-oncogenes and telomeres. The prominence in such sites suggests G-quadruplexes serve an important regulatory role in the cell. Indeed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7d9282275956ba4bfc2dab9e3798e9
https://doi.org/10.1093/nar/gkaa1172
https://doi.org/10.1093/nar/gkaa1172
Autor:
Luigi Ferrucci, Katrina N Estep, Thomas J. Butler, Robert W. Maul, David Schlessinger, Andrew R. Wood, Marcus A. Tuke, Joshua A. Sommers, Thomas A. Guilliam, Francesco Cucca, Daniel F. Bogenhagen, Alicia K. Byrd, Aidan J. Doherty, Stefania Bandinelli, Robert M. Brosh, Sanjay Kumar Bharti, Elena Yakubovskaya, Miguel Garcia-Diaz, Ann Zenobia Moore, Jun Ding, Kevin D. Raney
Publikováno v:
Hum Mol Genet
As the powerhouses of the eukaryotic cell, mitochondria must maintain their genomes which encode proteins essential for energy production. Mitochondria are characterized by guanine-rich DNA sequences that spontaneously form unusual three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afb2d119be5d18078f77c07bad4b4f8
https://doi.org/10.1093/hmg/ddaa043
https://doi.org/10.1093/hmg/ddaa043
Publikováno v:
Methods in Enzymology ISBN: 9780323914765
Methods Enzymol
Methods Enzymol
Helicases function in most biological processes that utilize nucleic acids including replication, recombination, repair, transcription, splicing, translation and other processes that involve RNA or DNA. They are motor proteins that bind ATP then cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11afdc486e665ac7c3a9ef6c435322ea
https://doi.org/10.1016/bs.mie.2022.03.066
https://doi.org/10.1016/bs.mie.2022.03.066
Publikováno v:
The Enzymes
RNA viruses cause many routine illnesses, such as the common cold and the flu. Recently, more deadly diseases have emerged from this family of viruses. The hepatitis C virus has had a devastating impact worldwide. Despite the cures developed in the U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a8ad6b2f4c7a2f804ca7991fd1a53edf
http://europepmc.org/articles/PMC8562938
http://europepmc.org/articles/PMC8562938
Publikováno v:
Journal of Biological Chemistry. 298:102486
Hepatitis C virus (HCV) is a major cause of liver-related diseases and hepatocellular carcinoma. The helicase domain of one of the nonstructural proteins of HCV, NS3 (nonstructural protein 3), is essential for viral replication; however, its specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd32adaa2d7f57a69519f3c769b1e205
https://doi.org/10.1016/j.jbc.2022.102486
https://doi.org/10.1016/j.jbc.2022.102486