Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Kevin D Pavelko"'
Autor:
Courtney S Malo, Danielle N Renner, April M Huseby Kelcher, Fang Jin, Michael J Hansen, Kevin D Pavelko, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0162064 (2016)
Virus vector-based vaccination against tumor-specific antigens remains a promising therapeutic approach to overcome the immune suppressive tumor microenvironment. However, the extent that the desired CD8 T cell response against the targeted tumor ant
Externí odkaz:
https://doaj.org/article/1dfc8de581a0428bab4e518a13d107f1
Autor:
Danielle N Renner, Fang Jin, Adam J Litterman, Alexis J Balgeman, Lisa M Hanson, Jeffrey D Gamez, Michael Chae, Brett L Carlson, Jann N Sarkaria, Ian F Parney, John R Ohlfest, Istvan Pirko, Kevin D Pavelko, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125565 (2015)
Glioblastoma (GBM) is among the most invasive and lethal of cancers, frequently infiltrating surrounding healthy tissue and giving rise to rapid recurrence. It is therefore critical to establish experimental model systems and develop therapeutic appr
Externí odkaz:
https://doaj.org/article/90232fcf3569472f97f5f1698045350b
Autor:
Brendan K Reed, Laura B Chopp, Courtney S Malo, Danielle N Renner, Virginia S Van Keulen, Megan A Girtman, Wendy N Nevala, Kevin D Pavelko, Diana Gil, Adam G Schrum, Aaron J Johnson, Larry R Pease
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137984 (2015)
Antigen-specific T cell responses can be visualized using MHC:peptide multimers. In cases where robust T cell controls are not readily available to assess the integrity of multimer reagents prior to analyzing limited sample, the ability to assess the
Externí odkaz:
https://doaj.org/article/1fb448f2255f452cad3fed8f44b99cae
An elite controller of picornavirus infection targets an epitope that is resistant to immune escape.
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94332 (2014)
The emergence of novel viral pathogens can lead to devastating consequences in the infected population. However, on occasion, rare hyper-responsive elite controllers are able to mount a protective primary response to infection and clear the new patho
Externí odkaz:
https://doaj.org/article/6e2ccd59f6044b0fab2cda0383b561a8
Autor:
Mireille Khoury, Qianqian Guo, Kunimaro Furuta, Cristina Correia, Chady Meroueh, Hyun Se Kim Lee, Khaled Warasnhe, Lucía Valenzuela-Pérez, Andrew P. Mazar, Iljung Kim, Yung-Kyun Noh, Heather Holmes, Michael F. Romero, Caroline R. Sussman, Kevin D. Pavelko, Shahidul Islam, Adebowale O. Bamidele, Petra Hirsova, Hu Li, Samar H. Ibrahim
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101073- (2024)
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation. Monocyte adhesion to liver sinusoidal endothelial cells (LSECs) and transend
Externí odkaz:
https://doaj.org/article/140f68733e754e61917380b70dbef94e
Autor:
Anuradha Krishnan, Nazli Begum Ozturk, Kaiyel A. Cutshaw, Maria Eugenia Guicciardi, Takashi Kitagataya, Kirsta E. Olson, Kevin D. Pavelko, William Sherman, Alexander Q. Wixom, Nidhi Jalan-Sakrikar, Michelle Baez-Faria, Florencia Gutierrez, Gregory J. Gores
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Ductular reactive (DR) cells exacerbate cholestatic liver injury and fibrosis. Herein, we posit that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) emanates from recruited macrophages and restrains DR cell expansion, thereby
Externí odkaz:
https://doaj.org/article/36650741471d4bd18d0ae191c826688e
Autor:
Kevin D Pavelko, Yanice Mendez-Fernandez, Michael P Bell, Michael J Hansen, Aaron J Johnson, Chella S David, Moses Rodriguez, Larry R Pease
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002541 (2012)
Structural diversity in the peptide binding sites of the redundant classical MHC antigen presenting molecules is strongly selected in humans and mice. Although the encoded antigen presenting molecules overlap in antigen presenting function, differenc
Externí odkaz:
https://doaj.org/article/7dcf3487afb54423960fe2037f440ab2
Autor:
Istvan Pirko, Yi Chen, Anne K Lohrey, Jeremiah McDole, Jeffrey D Gamez, Kathleen S Allen, Kevin D Pavelko, Diana M Lindquist, R Scott Dunn, Slobodan I Macura, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31459 (2012)
MRI is sensitive to tissue pathology in multiple sclerosis (MS); however, most lesional MRI findings have limited correlation with disability. Chronic T1 hypointense lesions or "T1 black holes" (T1BH), observed in a subset of MS patients and thought
Externí odkaz:
https://doaj.org/article/62624d18afa148c58f91e3203c4c2c51
Autor:
Kevin D Pavelko, Megan A Girtman, Yoshihiro Mitsunaga, Yanice V Mendez-Fernandez, Michael P Bell, Michael J Hansen, Kathleen S Allen, Moses Rodriguez, Larry R Pease
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20217 (2011)
The induction of sterilizing T-cell responses to tumors is a major goal in the development of T-cell vaccines for treating cancer. Although specific components of anti-viral CD8+ immunity are well characterized, we still lack the ability to mimic vir
Externí odkaz:
https://doaj.org/article/e5ea32cb816042768471f0c82d886e5e
Autor:
Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Daniel P. Larson, Raymond M. Moore, Matthew J. Maurer, Kevin D. Pavelko, Shahrzad Jalali, Joshua C. Pritchett, Rekha Mudappathi, Junwen Wang, Jose C. Villasboas, Patrizia Mondello, Anne J. Novak, Stephen M. Ansell
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore an
Externí odkaz:
https://doaj.org/article/68061377fe3a4dd6afecfc6420358ff6