Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Kevin D Niswender"'
Autor:
Robert L Barry, Nellie E Byun, Jason M Williams, Michael A Siuta, Mohammed N Tantawy, Nicole K Speed, Christine Saunders, Aurelio Galli, Kevin D Niswender, Malcolm J Avison
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191299 (2018)
OBJECTIVE:We have previously demonstrated that insulin signaling, through the downstream signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine-tunes dopamine (DA) signaling at the synapse. This suggests a mech
Externí odkaz:
https://doaj.org/article/4ab243630fcb41ab89b1bd6febe8ed08
Autor:
Katherine N Bachmann, Serpil Muge Deger, Aseel Alsouqi, Shi Huang, Meng Xu, Jane F Ferguson, Yan Ru Su, Kevin D Niswender, T Alp Ikizler, Thomas J Wang
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196869 (2018)
The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been p
Externí odkaz:
https://doaj.org/article/097c912cc3ff4f9abfdf360e1dc040b9
Autor:
Kristen L Eckstrand, Nishit Mummareddy, Hakmook Kang, Ronald Cowan, Minchun Zhou, David Zald, Heidi J Silver, Kevin D Niswender, Malcolm J Avison
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189113 (2017)
Central insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact
Externí odkaz:
https://doaj.org/article/d377112acfb04a9d996c3c178728c5b1
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137970 (2015)
In mammals a network of circadian clocks coordinates behavior and physiology with 24-h environmental cycles. Consumption of high-fat diet disrupts this temporal coordination by advancing the phase of the liver molecular clock and altering daily rhyth
Externí odkaz:
https://doaj.org/article/e7b03a6f1a114b77a3d555229c4a9076
Publikováno v:
Frontiers in Psychology, Vol 5 (2014)
Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesog
Externí odkaz:
https://doaj.org/article/fc827229680643bdad136679953b268c
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30254 (2012)
The mammalian circadian system is composed of multiple central and peripheral clocks that are temporally coordinated to synchronize physiology and behavior with environmental cycles. Mammals have three homologs of the circadian Period gene (Per1, 2,
Externí odkaz:
https://doaj.org/article/70bf88fbd7204a05b4c700610797e276
Autor:
Heidi J Silver, Kevin D Niswender, Charles D Keil, Lan Jiang, Qiping Feng, Sally Chiu, Ronald M Krauss, Russell A Wilke
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36166 (2012)
Success in further reducing the burden of cardiovascular disease (CVD) is threatened by the increasing prevalence of obesity-related atherogenic dyslipidemia. HDL-cholesterol (HDL-C) level is inversely correlated with CVD risk; each 1 mg/dl decrease
Externí odkaz:
https://doaj.org/article/4a75fddee70d4244abee8107b0576a2e
Autor:
Heidi E Kocalis, Maxine K Turney, Richard L Printz, Gloria N Laryea, Louis J Muglia, Sean S Davies, Gregg D Stanwood, Owen P McGuinness, Kevin D Niswender
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42981 (2012)
Central nervous system (CNS) lipid accumulation, inflammation and resistance to adipo-regulatory hormones, such as insulin and leptin, are implicated in the pathogenesis of diet-induced obesity (DIO). Peroxisome proliferator-activated receptors (PPAR
Externí odkaz:
https://doaj.org/article/d01e8aeecf8a48b1bf8c456659f8c09a
Autor:
Nicole Speed, Christine Saunders, Adeola R Davis, W Anthony Owens, Heinrich J G Matthies, Sanaz Saadat, Jack P Kennedy, Roxanne A Vaughan, Rachael L Neve, Craig W Lindsley, Scott J Russo, Lynette C Daws, Kevin D Niswender, Aurelio Galli
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25169 (2011)
BackgroundThe prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address "food-abuse" disorders. We demonstrate a molecular link between impairment of a cen
Externí odkaz:
https://doaj.org/article/05ed995f3cb24c789dbad3cf779f0c17
Autor:
Michael A Siuta, Sabrina D Robertson, Heidi Kocalis, Christine Saunders, Paul J Gresch, Vivek Khatri, Chiyo Shiota, J Philip Kennedy, Craig W Lindsley, Lynette C Daws, Daniel B Polley, Jeremy Veenstra-Vanderweele, Gregg D Stanwood, Mark A Magnuson, Kevin D Niswender, Aurelio Galli
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000393 (2010)
The mammalian target of rapamycin (mTOR) complex 2 (mTORC2) is a multimeric signaling unit that phosphorylates protein kinase B/Akt following hormonal and growth factor stimulation. Defective Akt phosphorylation at the mTORC2-catalyzed Ser473 site ha
Externí odkaz:
https://doaj.org/article/942dd17eaf5e479aaeb6b66a47857f35