Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kevin D G Pfleger"'
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202408 (2018)
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate immune response. TLR1 and 2 heterodimerize at the plasma membrane upon binding to triacylat
Externí odkaz:
https://doaj.org/article/a0e0618a92624bf9b0b0550edefe4b44
Autor:
Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119803 (2015)
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathw
Externí odkaz:
https://doaj.org/article/825dcccc2ee44c6ca84f5db253560016
Autor:
Mohammed Akli eAyoub, Julien eTrebaux, Julie eVallaghe, Fabienne eCharrier-Savournin, Khaled eAl-Hosaini, Arturo eGonzalez-Moya, Jean-Philippe R Pin, Kevin D G Pfleger, Eric eTrinquet
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signalling pathways regulating diverse biological responses. This signalling is characterized by phosphorylation cascades leading to ERK1/2 activation and
Externí odkaz:
https://doaj.org/article/583f6d766fab406cb3c3a7bab1991e80
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
G protein-coupled receptors (GPCRs) function in complexes with a range of molecules and proteins including ligands, G proteins, arrestins, ubiquitin and other receptors. Elements of these complexes may interact constitutively or dynamically, dependen
Externí odkaz:
https://doaj.org/article/66419fb7d5af445889ae7876ec2c7553
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64672 (2013)
Heteromerization can play an important role in regulating the activation and/or signal transduction of most forms of receptors, including receptor tyrosine kinases (RTKs). The study of receptor heteromerization has evolved extensively with the emerge
Externí odkaz:
https://doaj.org/article/d870170f9b334f9a81b05246836f9afe
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65885 (2013)
Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to incre
Externí odkaz:
https://doaj.org/article/f326b9946bf546a8bc111b7d44bc2a91
Autor:
Mohammed Akli Ayoub, Dora Angelicheva, David Vile, David Chandler, Bharti Morar, Juleen A Cavanaugh, Peter M Visscher, Assen Jablensky, Kevin D G Pfleger, Luba Kalaydjieva
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32849 (2012)
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the
Externí odkaz:
https://doaj.org/article/bcb99bb2a31f46f09b9bce709f1ef34a
Publikováno v:
Biochemical Society Transactions
Many receptors are able to undergo heteromerisation, leading to the formation of receptor complexes that may have pharmacological profiles distinct from those of the individual receptors. As a consequence of this, receptor heteromers can be classed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b53dc4a3e76deb842e217eeeeaefc7a
https://doi.org/10.1042/bst20201110
https://doi.org/10.1042/bst20201110
Autor:
Elizabeth K M, Johnstone, Mohammed Akli, Ayoub, Rebecca J, Hertzman, Heng B, See, Rekhati S, Abhayawardana, Ruth M, Seeber, Kevin D G, Pfleger
Publikováno v:
Frontiers in Endocrinology. 13
The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3bffc81a6c3ba8485a23e8c9657914
https://doi.org/10.3389/fendo.2022.848816
https://doi.org/10.3389/fendo.2022.848816
Autor:
Natasha C. Dale, Daniel Hoyer, Laura H. Jacobson, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone
Publikováno v:
Frontiers in cellular neuroscience. 16
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B). For the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19721518a8892df625b54a9d6e9b5e07
https://pubmed.ncbi.nlm.nih.gov/35496914
https://pubmed.ncbi.nlm.nih.gov/35496914