Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kevin D G, Pfleger"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
G protein-coupled receptors (GPCRs) are capable of interacting to form higher order structures such as homomers and heteromers. Heteromerisation in particular has implications for receptor function, with research showing receptors can attain unique e
Externí odkaz:
https://doaj.org/article/bca4f33656444636bc98420ffa0346bc
Autor:
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic repro
Externí odkaz:
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a
Autor:
Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Rebecca J. Hertzman, Heng B. See, Rekhati S. Abhayawardana, Ruth M. Seeber, Kevin D. G. Pfleger
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and ther
Externí odkaz:
https://doaj.org/article/05b7a90cfa2845508b41819310d3747e
Autor:
Natasha C. Dale, Daniel Hoyer, Laura H. Jacobson, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B). For the recepto
Externí odkaz:
https://doaj.org/article/1a03bd424f604276a66a0509a4f1b3c5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. Ho
Externí odkaz:
https://doaj.org/article/7b3fcf6037e049f69f6a0bb8d24be1b0
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Bioluminescence resonance energy transfer (BRET) is a biophysical technique used to monitor proximity within live cells. BRET exploits the naturally occurring phenomenon of dipole-dipole energy transfer from a donor enzyme (luciferase) to an acceptor
Externí odkaz:
https://doaj.org/article/af415a5501e44f34a985747f9c785f07
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202408 (2018)
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate immune response. TLR1 and 2 heterodimerize at the plasma membrane upon binding to triacylat
Externí odkaz:
https://doaj.org/article/a0e0618a92624bf9b0b0550edefe4b44
Publikováno v:
Biochemical Society Transactions
Many receptors are able to undergo heteromerisation, leading to the formation of receptor complexes that may have pharmacological profiles distinct from those of the individual receptors. As a consequence of this, receptor heteromers can be classed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b53dc4a3e76deb842e217eeeeaefc7a
https://doi.org/10.1042/bst20201110
https://doi.org/10.1042/bst20201110
Autor:
Natasha C. Dale, Daniel Hoyer, Laura H. Jacobson, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone
Publikováno v:
Frontiers in cellular neuroscience. 16
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B). For the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19721518a8892df625b54a9d6e9b5e07
https://pubmed.ncbi.nlm.nih.gov/35496914
https://pubmed.ncbi.nlm.nih.gov/35496914
Autor:
Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119803 (2015)
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathw
Externí odkaz:
https://doaj.org/article/825dcccc2ee44c6ca84f5db253560016