Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kevin D Bunker"'
Autor:
Kevin D Bunker, Robert J. Christy, Kristin M Reddoch-Cardenas, Bopaiah P. Cheppudira, Deborah Helen Slee, Chad Daniel Hopkins, Thomas H. Garza, Andrew P. Cap, James A. Bynum
Publikováno v:
Transfusion. 61
BACKGROUND: Acetaminophen (APAP) is a widely self-prescribed analgesic for mild to moderate pain, but overdose or repeat doses can lead to liver injury and death. Kalyra Pharmaceuticals has developed a novel APAP analog, KP-1199, currently in Phase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9933c7759ad6a85fc36e28a4d9dc56ff
https://doi.org/10.1111/trf.16497
https://doi.org/10.1111/trf.16497
Autor:
Hooman Izadi, Noah Ibrahim, Tiffany Hoang, Jianhui Ma, Petrus R. de Jong, Joseph Pinchman, Kevin D. Bunker, Ahmed A. Samatar, Fernando Doñate
Publikováno v:
Cancer Research. 82:2605-2605
Background: Wee1 is a crucial cell cycle checkpoint kinase that regulates the G2/M checkpoint in response to DNA damage, and its inhibition can cause mitotic catastrophe and apoptosis in tumor cells. Inhibitors of BCL-2 have been shown to also induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::897f5b11bbb9da216ac8cbd1fd5b7c3d
https://doi.org/10.1158/1538-7445.am2022-2605
https://doi.org/10.1158/1538-7445.am2022-2605
Autor:
Hooman Izadi, Tiffany Hoang, Noah Ibrahim, Joseph Pinchman, Brant C. Boren, Jianhui Ma, Petrus R. de Jong, Jiali Li, Kevin D. Bunker, Ahmed A. Samatar, Fernando Doñate
Publikováno v:
Cancer Research. 82:2591-2591
Background: The Bcl-2 inhibitor venetoclax is approved in combination with hypomethylating agents such as azacitidine for the treatment of newly diagnosed elderly patients with AML; however, most patients eventually relapse, especially those with TP5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ee78e0f7d82dff03a9e34cfdc164c68
https://doi.org/10.1158/1538-7445.am2022-2591
https://doi.org/10.1158/1538-7445.am2022-2591
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 6, Pp o1448-o1448 (2010)
The reaction of 2,4-dichloro-5-(trifluoromethyl)pyrimidine with 1H-pyrazole gave two structural isomers in a 1:1 ratio that were separable by chromatography. The title compound, C8H4ClF3N4, was the first product to elute and was characterized in the
Externí odkaz:
https://doaj.org/article/b6ef9e20125a410d80456f660022e127
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 12, Pp o3259-o3259 (2009)
The title compound, C9H7ClN2O2, was prepared by reaction of methyl 4-chloro-3-(prop-1-ynyl)picolinate with hydroxylamine in MeOH/KOH solution. The two essentially planar molecules which make up the asymmetric unit have almost identical geometries and
Externí odkaz:
https://doaj.org/article/f9c3cf689a00465a89ea8db855587d2d
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 1, Pp o28-o28 (2009)
The reaction of 3-amino-5-bromopyridine with N-iodosuccinimide in the presence of acetic acid produces the title compound, C5H4BrIN, with an iodo substituent in position 2 of the pyridine ring. The crystal structure features rather weak intermolecula
Externí odkaz:
https://doaj.org/article/1a5dda85498e449ba1b5813ff2ddaf25
Autor:
Kevin D. Bunker, Peter Qinhua Huang, Jianhui Ma, Fernando Doñate, Jiali Li, Sunny Abraham, Ahmed A. Samatar
Publikováno v:
Cancer Research. 81:2423-2423
Small molecule tyrosine kinase inhibitors against the epidermal growth factor (EGFR) have made significant impact in the treatment of advanced non-small-cell lung cancer (NSCLC) with activating EGFR mutations. Although the first and second-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8104d490fd6725b3770706b6a82ec2b5
https://doi.org/10.1158/1538-7445.am2021-2423
https://doi.org/10.1158/1538-7445.am2021-2423
Autor:
Kevin D. Bunker, Ahmed A. Samatar, Fernando Doñate, Jiali Li, Brant C Boren, Peter Qinhua Huang
Publikováno v:
Cancer Research. 81:1965-1965
Genome instability initiated by DNA damage or DNA replication stress is a driver of tumor development. To ensure the accuracy of DNA replication, DNA damage response (DDR) mediated by various cell cycle checkpoints activate the DNA repair system. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e2c854a6df9a0b3615953ec8566fcd
https://doi.org/10.1158/1538-7445.am2021-1965
https://doi.org/10.1158/1538-7445.am2021-1965
Autor:
Joseph M. O'Connor, Arnold L. Rheingold, Kevin D. Bunker, Kim K. Baldridge, Ryan L. Holland, Pengjin Qin
Publikováno v:
The Journal of organic chemistry. 84(21)
Here, we report that trifluoroacetic acid (TFAH) induces demetallation and protodesilylation of the cyclopentadiene ligand in cobalt-η4-cyclopentadiene complexes of general formula [(η5-C5H5)Co(η4-exo-C(TMS)═C(SO2Ph)CH═CRCH(CO2Et))] (1-Ph, R =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059ee8e0b77d9c706cd7997631112970
https://pubmed.ncbi.nlm.nih.gov/31549512
https://pubmed.ncbi.nlm.nih.gov/31549512
Autor:
Kevin D. Bunker, Joseph M. O'Connor, Stephen K. Cope, Ryan L. Holland, Pengjin Qin, Kim K. Baldridge, Jay S. Siegel
Publikováno v:
Synlett. 26:2243-2246
Three diastereomers of a highly functionalized tetrasubstituted cyclopentadienylcobalt-diene complex, (Cp)Co[η4-CH(CO2Et)=C(SO2Ph)C(SiMe3)=CH(CO2Et)] (4-ZE, 4-EZ, 4-ZZ; Cp = C5H5), undergo oxidative demetallation by ceric ammonium nitrate (CAN) to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b7ca9f360c1d7105b0257a3f8fa5c2
https://doi.org/10.1055/s-0035-1560092
https://doi.org/10.1055/s-0035-1560092