Výsledky vyhledávání - "Kevin D, Fowler"

Abstract 4265: Humanized 3D tumor models that are mutationally aligned with AACR GENIE patients predict IMM-1-104 activity in RAS-addicted tumors

Autor: Praveen Nair, Sarah Kolitz, Jason Funt, Peter J. King, Kevin D. Fowler, Anna Travesa, Ian Rose, John Brothers, Amy Axel, Scott Barrett, Benjamin J. Zeskind, Brett M. Hall

Publikováno v: Cancer Research. 83:4265-4265

Introduction: IMM-1-104, with pan-RAS activity through deep cyclic inhibition MEK, was evaluated in humanized 3D preclinical tumor models displaying diverse MAPK pathway activation events. Based on drug-response, sensitivity and resistance profiles,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e25c00c6741ef31b0cde90a876652c2
https://doi.org/10.1158/1538-7445.am2023-4265

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Akademický článek

Comparing the biological impact of glatiramer acetate with the biological impact of a generic.

Autor: Fadi Towfic, Jason M Funt, Kevin D Fowler, Shlomo Bakshi, Eran Blaugrund, Maxim N Artyomov, Michael R Hayden, David Ladkani, Rivka Schwartz, Benjamin Zeskind

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e83757 (2014)

For decades, policies regarding generic medicines have sought to provide patients with economical access to safe and effective drugs, while encouraging the development of new therapies. This balance is becoming more challenging for physicians and reg

Externí odkaz: https://doaj.org/article/d9ac4720e37d456aa3e0668f876f8ecc

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Akademický článek

A model for how signal duration can determine distinct outcomes of gene transcription programs.

Autor: Kevin D Fowler, Vijay K Kuchroo, Arup K Chakraborty

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33018 (2012)

The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that IL-6 induces a transient STAT

Externí odkaz: https://doaj.org/article/2a87d9c3fb3d45098f62c4ab09eafe47

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Abstract P254: Transcriptional effects in C26 tumor highlight mechanistic aspects of a novel dual MEK inhibitor, IMM-1-104

Autor: Sarah E. Kolitz, Kevin D. Fowler, Peter J. King, Benjamin J. Zeskind, Brett M. Hall

Publikováno v: Molecular Cancer Therapeutics. 20:P254-P254

We developed a novel dual MEK inhibitor, IMM-1-104, that showed 94% tumor growth inhibition (TGI) in the syngeneic C26 mouse model through 10 days at 150 mg/kg (mpk) BID, with only 3.8% tumor-adjusted body weight loss (BWL) through 24 days. The mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfbd18d1d14daf779848e89c2e5f267e
https://doi.org/10.1158/1535-7163.targ-21-p254

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Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model

Autor: Peter J. King, Amy E. Axel, Kevin D. Fowler, Sarah E. Kolitz, Scott Barrett, Benjamin J. Zeskind, Brett M. Hall

Publikováno v: Molecular Cancer Therapeutics. 20:P240-P240

Background: Approximately 9 out of 10 patients diagnosed with pancreatic cancer have tumors driven by a single activating mutation in KRAS. These tumors remain unaddressable by current therapies and collectively represent a high unmet clinical need.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b1327f5d00faa5238830f791bdd74d7
https://doi.org/10.1158/1535-7163.targ-21-p240

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Abstract P252: IMM-1-104: a novel, oral, selective dual-MEK inhibitor that displays broad antitumor activity and high tolerability across RAS and RAF mutant tumors in vivo

Autor: Peter J. King, Kevin D. Fowler, Sarah E. Kolitz, Scott Barrett, Benjamin J. Zeskind, Brett M. Hall

Publikováno v: Molecular Cancer Therapeutics. 20:P252-P252

Background: Inappropriate activation of the MAPK pathway, often stemming from mutations in RAS or RAF, represents one of the most common oncogenic events in human cancer. Therefore, MEK1 and MEK2 (MEK), which lie downstream of RAS and RAF but upstrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44c30e2e29b99c02a9568ee8562dc3b1
https://doi.org/10.1158/1535-7163.targ-21-p252

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Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model

Autor: Arthur Komlosh, Kevin Wells-Knecht, Michael R. Hayden, Vera Weinstein, Adrian Gilbert, Attila Konya, Kevin D. Fowler, Revital Krispin, Sarah Kolitz, Sigal Melamed-Gal, Iris Grossman, Pippa S. Loupe, Galia Papir, Yousif Sahly, Benjamin Zeskind, Oren Bar-Ilan, Daphna Laifenfeld, Tal Hasson, Tatiana Molotsky

Publikováno v: Annals of the New York Academy of Sciences. 1407:75-89

Copaxone (glatiramer acetate, GA), a structurally and compositionally complex polypeptide nonbiological drug, is an effective treatment for multiple sclerosis, with a well-established favorable safety profile. The short antigenic polypeptide sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e805a204083fa8717e72cb2f2c739839
https://doi.org/10.1111/nyas.13547

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IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

Autor: Anneli Peters, Kevin D. Fowler, Caroline Pot, Fanny Chalmin, Doron Merkler, Vijay K. Kuchroo

Publikováno v: Journal of immunology (Baltimore Md. : 1950)
Journal of Immunology, Vol. 195, No 9 (2015) pp. 4144-4153

It is known that differentiation of Th17 cells is promoted by activation of STAT3 and inhibited by activation of STAT1. Although both transcription factors are activated by several cytokines, including IL-6, IL-21, and IL-27, each of these cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb293352a4cca67524f82b82e153c74

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Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model

Autor: Iris, Grossman, Sarah, Kolitz, Arthur, Komlosh, Benjamin, Zeskind, Vera, Weinstein, Daphna, Laifenfeld, Adrian, Gilbert, Oren, Bar-Ilan, Kevin D, Fowler, Tal, Hasson, Attila, Konya, Kevin, Wells-Knecht, Pippa, Loupe, Sigal, Melamed-Gal, Tatiana, Molotsky, Revital, Krispin, Galia, Papir, Yousif, Sahly, Michael R, Hayden

Publikováno v: Annals of the New York Academy of Sciences. 1407(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae778f6ad38cfd95959aa6370db0214f
https://pubmed.ncbi.nlm.nih.gov/29168242

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Pridopidine activates neuroprotective pathways impaired in Huntington Disease

Autor: Fadi Towfic, Aric Orbach, Steve Barash, Yoonjeong Cha, Tal Birnberg, Avia Merenlender Wagner, Andrew C. Lysaght, Ben Zeskind, Tania Fine, Rebecca Kusko, Michal Geva, Sarah Kolitz, Michael R. Hayden, Brian Weiner, Holly Soares, Iris Grossman, Kevin D. Fowler, Ralph Laufer

Publikováno v: Human Molecular Genetics

Pridopidine has demonstrated improvement in Huntington Disease (HD) motor symptoms as measured by secondary endpoints in clinical trials. Originally described as a dopamine stabilizer, this mechanism is insufficient to explain the clinical and precli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7194142aa4c5db7b2ae2053740bb66
https://pubmed.ncbi.nlm.nih.gov/27466197

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