Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Kevin D, Deane"'
Autor:
Salina H. Goff, Dylan T. Bergstedt, Marie L. Feser, LauraKay Moss, Ted R. Mikuls, Jess D. Edison, V. Michael Holers, Laura Martinez‐Prat, Mary Ann R. Aure, Michael Mahler, Kevin D. Deane
Publikováno v:
ACR Open Rheumatology, Vol 6, Iss 9, Pp 587-597 (2024)
Objective Rheumatoid arthritis (RA) has a “pre‐RA” period in which multiple autoantibodies, including antibodies to citrullinated (cit) proteins (ACPA), rheumatoid factor (RF), anti–peptidyl arginine deiminase (anti‐PAD), among others, have
Externí odkaz:
https://doaj.org/article/f06de7f98462462fa48bdd3b89115bf0
Autor:
Eleanor Frost, Jonathan N. Hofmann, Wen-Yi Huang, Ashley A. Frazer-Abel, Kevin D. Deane, Sonja I. Berndt
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-4 (2024)
Impact Immune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell mat
Externí odkaz:
https://doaj.org/article/522b372010884846b2e334056e9c60a6
Autor:
Heather A. Nelson, Dipanwita Banerjee, Camille L. Novis, Kevin D. Deane, Marie L. Feser, Vijayalakshmi Nandakumar
Publikováno v:
Practical Laboratory Medicine, Vol 41, Iss , Pp e00420- (2024)
Background: Anti-citrullinated protein antibodies (ACPA) are a specific serological biomarker used in the diagnosis of rheumatoid arthritis (RA). In clinical practice ACPA can be identified using immunoassays targeting synthetic cyclic citrullinated
Externí odkaz:
https://doaj.org/article/981c66e252424a77886d4d3bc78fbc57
Autor:
Eddie A. James, V. Michael Holers, Radhika Iyer, E. Barton Prideaux, Navin L. Rao, Cliff Rims, Virginia S. Muir, Sylvia E. Posso, Michelle S. Bloom, Amin Zia, Serra E. Elliott, Julia Z. Adamska, Rizi Ai, R. Camille Brewer, Jennifer A. Seifert, LauraKay Moss, Saman Barzideh, M. Kristen Demoruelle, Christopher C. Striebich, Yuko Okamoto, Enkhtsogt Sainbayar, Alexandra A. Crook, Ryan A. Peterson, Lauren A. Vanderlinden, Wei Wang, David L. Boyle, William H. Robinson, Jane H. Buckner, Gary S. Firestein, Kevin D. Deane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here
Externí odkaz:
https://doaj.org/article/a3d2e67207bd4673ae2092ef39c22e10
Autor:
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in bl
Externí odkaz:
https://doaj.org/article/256fdecef1e149f1a62547c63372d7f7
Autor:
Chelsie L. Fleischer, Elizabeth A. Bemis, Marie L. Feser, Vasilisa A. Kormendi, Alvina Zhang, Katherine Ketcham, Sharon D. White, Christopher C. Striebich, Kevin D. Deane, Mark Harrison
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 11, Pp 974-982 (2022)
Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPA) can be elevated prior to inflammatory arthritis (IA). The potential to intervene in people with ACPA positivity underpins the development of prevention trials in R
Externí odkaz:
https://doaj.org/article/a3f748e315b740cb8bc49dd7c6fc9d2e
Autor:
V. Michael Holers, Kristine A. Kuhn, M. Kristen Demoruelle, Jill M. Norris, Gary S. Firestein, Eddie A. James, William H. Robinson, Jane H. Buckner, Kevin D. Deane
Publikováno v:
Rheumatology & Autoimmunity, Vol 2, Iss 3, Pp 109-119 (2022)
Abstract In seropositive rheumatoid arthritis (RA), the onset of clinically apparent inflammatory arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antib
Externí odkaz:
https://doaj.org/article/a023ec5f97084f0d8aed3f54c68b8020
Autor:
Vladislav Tsaltskan, Katherine Nguyen, Christina Eaglin, V. Michael Holers, Kevin D. Deane, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 7, Pp 623-630 (2022)
Objective Traditional nondigital methods of participant recruitment for clinical research studies in rheumatology can be costly and inefficient, particularly for recruitment of underserved populations. We aimed to address this need by evaluating two
Externí odkaz:
https://doaj.org/article/69b997f410a745d3b6c6c30bbab64508
Tumor-Associated and Systemic Autoimmunity in Pre-Clinical Breast Cancer among Post-Menopausal Women
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1566 (2023)
Autoantibodies to tumor-associated antigens (anti-TAA) are potential biomarkers for breast cancer, but their relationship systemic autoimmunity as ascertained though antinuclear antibodies (ANA) is unknown and warrants consideration given the common
Externí odkaz:
https://doaj.org/article/bc8a8df2ac0b44b9bfeeb6ca4009ae39
Autor:
Leah F. Bettner, Ryan A. Peterson, Dylan T. Bergstedt, Lindsay B. Kelmenson, M. Kristen Demoruelle, Ted R. Mikuls, Jess D. Edison, Mark C. Parish, Marie L. Feser, Ashley A. Frazer‐Abel, Laura K. Moss, Michael Mahler, V. Michael Holers, Kevin D. Deane
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 10, Pp 684-689 (2021)
Objective To evaluate the prevalence of elevations of anti‐cyclic citrullinated peptide‐3 (anti‐CCP3) antibody, rheumatoid factor IgM (RF‐IgM) and serum calprotectin (sCP) in pre–rheumatoid arthritis (RA) as well as the diagnostic accuracie
Externí odkaz:
https://doaj.org/article/a5af5db0fd4a4c6fb7259817c70681c7